Cationic antiseptic compositions and methods of use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-047/10
A61K-031/194
A61K-047/18
A61K-031/185
A61K-031/191
A61K-031/155
A61K-031/685
A61K-031/085
A61K-031/14
A61K-033/38
A61J-001/00
B65D-021/08
A61K-031/785
출원번호
US-0703911
(2015-05-05)
등록번호
US-10016501
(2018-07-10)
발명자
/ 주소
Scholz, Matthew T.
출원인 / 주소
3M INNOVATIVE PROPERTIES COMPANY
대리인 / 주소
3M Innovative Properties Company
인용정보
피인용 횟수 :
0인용 특허 :
68
초록▼
Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including a cationic antiseptic such as biguanides and bisbiguanides such as chlorhexidine and its various salts including but not limited to the digluconate, diaceta
Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including a cationic antiseptic such as biguanides and bisbiguanides such as chlorhexidine and its various salts including but not limited to the digluconate, diacetate, dimethosulfate, and dilactate salts; polymeric quaternary ammonium compounds such as polyhexamethylenebiguanide; silver and various silver complexes; small molecule quaternary ammonium compounds such as benzalkoium chloride and alkyl substituted derivatives; di-long chain alkyl (C8-C18) quaternary ammonium compounds; cetylpyridinium halides and their derivatives; benzethonium chloride and its alkyl substituted derivatives; and octenidine. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and/or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and/or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).
대표청구항▼
1. A method of killing microorganisms in the skin or mucosal tissue, the method comprising: i. providing an antiseptic composition comprising a cationic antiseptic having a concentration of at least 0.1% by weight, a phenolic enhancer having a concentration of at least 0.01% by weight, an enhancer h
1. A method of killing microorganisms in the skin or mucosal tissue, the method comprising: i. providing an antiseptic composition comprising a cationic antiseptic having a concentration of at least 0.1% by weight, a phenolic enhancer having a concentration of at least 0.01% by weight, an enhancer having a concentration of at least 0.25% by weight, wherein the enhancer is selected from the group consisting of alpha hydroxyacids, beta hydroxyacids, and chelators and combinations thereof, and a C1-C4 monohydroxy alcohol or mixtures thereof having a concentration of at least 20% by weight and not greater than 50% by weight, andii. applying the composition to the skin or mucosal tissue. 2. The method of claim 1 wherein the cationic antiseptic is selected from the group consisting of biguanides, bisbiguanides, polymeric quaternary ammonium compounds, polyhexamethylenebiguanide, silver, silver complexes, small molecule quaternary ammonium compounds and combinations thereof. 3. The method of claim 2, wherein the cationic antiseptic is a bisbiguanide. 4. The method of claim 3, wherein the bisbiguanide is a chlorhexidine salt selected from the group consisting of digluconate, diacetate, dimethosulfate, and dilactate salts and mixtures thereof. 5. The method of claim 2 wherein the cationic antiseptic is a polymeric quaternary ammonium compound selected from the group consisting of benzethonium chloride, its alkyl substituted derivatives, and octenidine. 6. The method of claim 2 wherein the cationic antiseptic is a small molecule quaternary ammonium compound. 7. The method of claim 6 wherein the small molecule quaternary ammonium compound has a molecular weight of less than 350. 8. The method of claim 1 wherein the enhancer comprises alpha hydroxy acid and a chelator. 9. The method of claim 8 wherein the enhancer is present in a concentration of at least 0.5% by weight. 10. The method of claim 8 wherein the enhancer is present in a concentration of at least 1% by weight. 11. The method of claim 1 wherein the enhancer is selected from the group consisting of lactic acid, malic acid, citric acid, 2-hydroxybutanoic acid, mandelic acid, gluconic acid, glycolic acid, tartaric acid, ascorbic acid, alpha-hydroxyoctanoic acid, alpha hydroxycaprylic acid, and combinations thereof. 12. The method of claim 1 wherein the phenolic enhancer is selected from compounds having the following general structure: wherein: m is 0 to 3, n is 1 to 3, each R12 independently is alkyl or alkenyl of up to 12 carbon atoms, and each R13 independently is H or alkyl or alkenyl of up to 8 carbon atoms. 13. The method of claim 12 wherein the phenolic enhancer is the phenol species where R13=H and where R12 is alkyl or alkenyl of up to 8 carbon atoms, and n is 1, 2, or 3. 14. The method of claim 12 wherein the phenolic enhancer is the phenol species wherein R12 is butyl or tert-butyl. 15. The method of claim 1 wherein the phenolic enhancer is selected from the group consisting of: 3(2)-tert-butyl-4-methoxyphenol (BHA), 2,6-di-tert-butyl-4-methylphenol (BHT), 3,5-di-tert-butyl-4-hydroxybenzylphenol, 2,6-di-tert-4-hexylphenol, 2,6-di-tert-4-octylphenol, 2,6-di-tert-4-decylphenol, 2,6-di-tert-butyl-4-ethylphenol, 2,6-di-tert-4-butylphenol, 2,5-di-tert-butylphenol, 3,5-di-tert-butylphenol, 4,6-di-tert-butyl-resorcinol, methyl paraben (4-hydroxybenzoic acid methyl ester), ethyl paraben, propyl paraben, butyl paraben, 2-phenoxyethanol, and combinations thereof. 16. The method of claim 1 wherein the phenolic enhancer is present in a total amount of at least 0.10 by weight. 17. The method of claim 1 wherein the phenolic enhancer is present in a total amount of at least 0.25 by weight. 18. The method of claim 1 wherein the composition further comprises a surfactant distinct from the cationic antiseptic, wherein the surfactant is present in a concentration of at least 0.1% by weight, and wherein the surfactant is selected from the group consisting of a sulfonate surfactant, a sulfate surfactant, a phosphonate surfactant, a phosphate surfactant, a poloxamer, a cationic surfactant, or mixtures thereof. 19. The method of claim 1 wherein the composition is contained in a collapsible container. 20. The method of claim 19, wherein the collapsible container is a flexible tube. 21. The method of claim 1, wherein the composition is free of anionic surfactants.
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