In one embodiment, the present invention includes a method for repairing a cartilage defect including: preparing a cartilage defect by removing unwanted or damaged tissue; creating at least one perforation into or through subchondral bone, below and/or adjacent to the cartilage defect to induce the
In one embodiment, the present invention includes a method for repairing a cartilage defect including: preparing a cartilage defect by removing unwanted or damaged tissue; creating at least one perforation into or through subchondral bone, below and/or adjacent to the cartilage defect to induce the flow of bone fluid; allowing the bone fluid to bleed through the at least one perforation up into the cartilage defect to fill at least a portion of the cartilage defect; and applying a biomaterial into the defect to produce a clot for cartilage regeneration.
대표청구항▼
1. A method for repairing a cartilage defect comprising: applying a tourniquet proximal to the cartilage defect;preparing a cartilage defect by removing unwanted or damaged tissue;creating at least one perforation into or through subchondral bone, below and/or adjacent to the cartilage defect to ind
1. A method for repairing a cartilage defect comprising: applying a tourniquet proximal to the cartilage defect;preparing a cartilage defect by removing unwanted or damaged tissue;creating at least one perforation into or through subchondral bone, below and/or adjacent to the cartilage defect to induce the flow of bone fluid;allowing the bone fluid to bleed through the at least one perforation up into the cartilage defect to fill at least a portion of the cartilage defect;removing the tourniquet to allow uninhibited bleeding up into the cartilage defect; andafter removing the tourniquet and allowing at least some bleeding into the cartilage defect to form a bloody bed in the cartilage defect, applying a surgical hemostat including thrombin and collagen into the bone fluid of the bloody bed so that the surgical hemostat intermixes with the bone fluid of the bloody bed to produce a clot for cartilage regeneration,wherein the intermixing of the surgical hemostat and the bone fluid forms an enhanced clot in the cartilage defect, andwherein the enhanced clot includes a matrix structure through which additional bone fluid migrates to replenish nutrients within the cartilage defect. 2. The method of claim 1, wherein the surgical hemostat is applied to the defect after bone fluid bleeds into the defect to fill at least a portion of the defect. 3. The method of claim 1, wherein the bone fluid and the applied surgical hemostat completely fill the cartilage defect. 4. The method of claim 1, wherein the bone fluid comprises blood, bone marrow, cells, or any combination. 5. The method of claim 1, wherein the step of applying the surgical hemostat results in the surgical hemostat positioned within the cartilage defect while the at least one perforation is substantially free of the surgical hemostat. 6. The method of claim 1, wherein the step of creating the at least one perforation is performed using an awl or pick. 7. The method of claim 1, wherein the collagen of the surgical hemostat is a microfibrillar collagen with fibrils between 3 nm and 30 nm in diameter and a melting temperature between 42° C. and 46° C. 8. The method of claim 1, wherein the step of creating the at least one perforation is performed using a drill. 9. The method of claim 8, wherein the drill includes a flexible drill and a curved drill guide adapted to direct the flexible drill along a predetermined angle of curvature. 10. A kit for repairing a cartilage defect comprising: a bone marrow stimulation instrument comprising at least one drill guide and a drill;a cap adapted to prevent migration of bone fluid, migrating into the cartilage defect through perforations in subchondral bone below and/or adjacent to the cartilage defect formed by the bone marrow stimulation instrument, away from the cartilage defect, the cap including a cannula and a filter positioned within the cannula, wherein the filter is adapted to extract extrudate from the bone fluid; anda surgical hemostat including collagen and thrombin, the surgical hemostat adapted to form an enhanced clot when applied to the bone fluid in the cartilage defect so that the surgical hemostat intermixes with the bone fluid, the enhanced clot including a matrix structure through which additional bone fluid migrates to replenish nutrients within the cartilage defect. 11. The kit of claim 10, wherein the collagen of the surgical hemostat is a microfibrillar collagen with fibrils between 3 nm and 30 nm in diameter and a melting temperature between 42° C. and 46° C. 12. The kit of claim 11, wherein the surgical hemostat further comprises polyethylene glycol in a concentration of 0.1 to 2.0%. 13. A method for creating a healing matrix for a cartilage defect in-situ comprising: preparing a cartilage defect by removing unwanted or damaged tissue;creating at least one perforation into or through subchondral bone below and/or adjacent to the cartilage defect to induce the flow of bone fluid;positioning a cap over the cartilage defect and at least one perforation;allowing the bone fluid to bleed through the at least one perforation up into the cartilage defect to fill at least a portion of the cartilage defect and form a bloody bed, the cap preventing the bone fluid from migrating out of the cartilage defect; andafter the bone fluid at least partially bleeds through the at least one perforation up into a defect area of the cartilage defect and a bloody bed is formed, applying a biomaterial into the bone fluid of the bloody bed in the defect area so that the biomaterial intermixes with the bone fluid to produce a clot for cartilage regeneration,wherein the intermixing of the biomaterial and the bone fluid in the defect area forms an enhanced clot, andwherein the enhanced clot includes a matrix structure through which additional bone fluid migrates to replenish nutrients within the cartilage defect. 14. The method of claim 13, wherein the biomaterial is applied to the cartilage defect through a cannulation in the cap. 15. The method of claim 13, wherein the steps of the method are performed arthroscopically. 16. The method of claim 13, further comprising the step of removing the cap once the enhanced clot stabilizes. 17. The method of claim 13, wherein the biomaterial includes a surgical hemostat. 18. The method of claim 17, wherein the surgical hemostat includes thrombin and a microfibrillar collagen having fibrils between 3 nm and 30 nm in diameter and a melting temperature between 42° C. and 46° C. 19. The method of claim 13, further comprising the step of providing suction to the cartilage defect, through a cannulation in the cap, to promote bleeding of bone fluid through the at least one perforation up into the cartilage defect. 20. The method of claim 19, further comprising a filter positioned within the cannulation to allow flow of an exudate portion of the bone fluid out of the cap through the filter and cannulation but prevent the flow of cells, platelets and nutrients from exiting the cap.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Huey, Raymond J.; Lo, Denny; Burns, Daniel J.; Basadonna, Giacomo; Hursey, Francis X., Clay-based hemostatic agents and devices for the delivery thereof.
Chu George H. (Sunnyvale CA) Ogawa Yasushi (Pacifica CA) McPherson John M. (Hopkinton MA) Ksander George (Redwood City CA) Pratt Bruce (Union City CA) Hendricks Diana (Brea CA) McMullin Hugh (San Bru, Collagen wound healing matrices and process for their production.
Prior Jeffrey J. ; Wallace Donald G. ; Sierra David H. ; DeLustro Frank A., Compositions containing thrombin and microfibrillar nanometer collagen, and methods for preparation and use thereof.
Rhee Woonza M. ; Berg Richard A. ; Chu George H. ; DeLustro Frank A. ; Jolivette Dan M. ; McCullough Kimberly A., Injectable or implantable biomaterials for filling or blocking lumens and voids of the body.
Shenoy Vivek N. (Sunnyvale CA) Revak Timothy T. (Los Altos CA) Chu George H. (Cupertino CA) McMullin Hugh R. (Menlo Park CA) Rosenblatt Joel S. (Palo Alto CA) Martin George R. (Bethesda MD), Method of controlling structure stability of collagen fibers produced form solutions or dispersions treated with sodium.
Edwardson Peter A. D.,GBX ; Fairbrother John E.,GBX ; Gardner Ronald S.,GBX ; Hollingsbee Derek A.,GBX ; Cederholm-Williams Stewart A.,GBX, Nondynamic fibrin monomer on bandages, sutures, prostheses and dressings.
Heimburger Norbert (Marburg DEX) Fuhge Peter (Lahntal DEX) Ronneberger Hansjrg (Marburg DEX), One-component tissue adhesive and a process for the production thereof.
Chu George H. (Sunnyvale CA) Ogawa Yasushi (Pacifica CA) McPherson John M. (Framingham MA) Ksander George (Redwood City CA) Pratt Bruce (Union City CA) Hendricks Diana (Brea CA) McMullin Hugh (San Br, Processes for producing collagen matrixes and methods of using same.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.