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A method includes acquiring image data from for a given time step. The image data represents at least one of an instrument and a target within an image space that includes patient anatomy. A given belief of system state is estimated to include an estimate of instrument state and target state determi

A method includes acquiring image data from for a given time step. The image data represents at least one of an instrument and a target within an image space that includes patient anatomy. A given belief of system state is estimated to include an estimate of instrument state and target state determined from corresponding measurement and motion models computed based on the acquired image data and control input parameters for the given time step. An expected belief of system state is estimated for a subsequent time step based on the estimated given belief of system state and based on the measurement models and the motion models computed over a plurality of different control inputs parameters. An information metric is computed for each of the expected beliefs of system state and control input parameters are selected for the subsequent time step based on the computed information metrics.

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1. A method comprising: acquiring image data from an imaging system for a given time step, the image data representing at least one of an instrument and a target within an image space that includes patient anatomy, the imaging system and an intervention system operating according to control input pa

1. A method comprising: acquiring image data from an imaging system for a given time step, the image data representing at least one of an instrument and a target within an image space that includes patient anatomy, the imaging system and an intervention system operating according to control input parameters;estimating a given belief of system state for the given time step, the given belief of system state for the given time step including an estimate of instrument state and target state determined from corresponding measurement and motion models computed based on the acquired image data and the control input parameters for the given time step, wherein the estimating the given belief of system state comprises using a Bayes filter function to compute the given belief of system state, the Bayes filter function comprises at least one of a particle filter to estimate a posterior density representing the given belief of system state or a Kalman filter function to estimate a mean and a covariance matrix representing the given belief of system state;estimating an expected belief of system state for a subsequent time step based on the estimated given belief of system state and based on the corresponding measurement and the motion models computed over a plurality of different control inputs parameters for at least one of the imaging system and the intervention system;computing information metrics for each of the expected belief of system states estimated for the subsequent time step; andselecting the control input parameters to control the at least one of the imaging system and the intervention system for the subsequent time step based on the computed information metrics. 2. The method of claim 1, further comprising: controlling the at least one of the imaging system and the intervention system the for the subsequent time step; andrepeating each of the acquiring estimating, computing, selecting and controlling over a plurality of next time steps. 3. The method of claim 1, wherein computing the information metric comprises computing an entropy of the estimated expected belief of system states, the selected control input parameters being selected to minimize the entropy. 4. The method of claim 1, wherein the control input parameters for the imaging system include at least two of a position of an imaging plane in the image space, an orientation of the imaging plane in the image space, a resolution, a scan speed, a scan duration and a scan area within the image space. 5. The method of claim 1, wherein the imaging system comprises an intraoperative imaging modality that operates based on imaging control input parameters, at least some of the imaging control input parameters being selected part of the control input parameters based on analysis of the computed information metrics. 6. The method of claim 5, wherein the intraoperative imaging modality comprises one of magnetic resonance imaging, ultrasound imaging, radiography, thermography or tomography. 7. The method of claim 1, wherein estimating the expected belief of system state further comprises using the Bayes filter function to compute the expected belief of system state. 8. The method of claim 1, further comprising controlling each of the imaging system and the intervention system the over time based on the control input parameters. 9. The method of claim 8, wherein control of the intervention system employs Jacobian-based controls or inverse kinematics based methods to control at least one parameter of the instrument. 10. The method of claim 1, wherein the instrument comprises a catheter and the intervention system includes a catheter control system for actively controlling the catheter, the method further comprises adjusting a position of the catheter relative to an estimated location of the target based on the control input parameters. 11. The method of claim 10, wherein the catheter comprises a plurality of multi-axial coils disposed about the catheter, the method further comprising positioning the catheter relative to the target in response to selectively applying current to the coils and in response to a magnetic field provided by the imaging system. 12. The method of claim 11, further comprising applying therapy from the catheter to the target. 13. A method comprising: acquiring image data from an imaging system for a given time step, the image data representing at least one of an instrument and a target within an image space that includes patient anatomy, the imaging system and an intervention system operating according to control input parameters;estimating a given belief of system state for the given time step, the given belief of system state for the given time step including an estimate of instrument state and target state determined from corresponding measurement and motion models computed based on the acquired image data and the control input parameters for the given time step,wherein the corresponding measurement model comprises:an instrument measurement model to compute a probability density function for the instrument to represent uncertainty in measurements of the instrument by the imaging system; anda target measurement model to compute a probability density function for the target to represent uncertainty in measurements of the instrument by the imaging system;estimating an expected belief of system state for a subsequent time step based on the estimated given belief of system state and based on the corresponding measurement and the motion models computed over a plurality of different control inputs parameters for at least one of the imaging system and the intervention system;computing information metrics for each of the expected belief of system states estimated for the subsequent time step; andselecting the control input parameters to control the at least one of the imaging system and the intervention system for the subsequent time step based on the computed information metrics. 14. A method comprising: acquiring image data from an imaging system for a given time step, the image data representing at least one of an instrument and a target within an image space that includes patient anatomy, the imaging system and an intervention system operating according to control input parameters;estimating a given belief of system state for the given time step, the given belief of system state for the given time step including an estimate of instrument state and target state determined from corresponding measurement and motion models computed based on the acquired image data and the control input parameters for the given time step,wherein the corresponding motion model comprises:an instrument motion model to compute a probability density function for the instrument to represent uncertainty in estimating motion of the instrument; anda target motion model to compute a probability density function for the target to represent uncertainty in estimating the motions of the target;estimating an expected belief of system state for a subsequent time step based on the estimated given belief of system state and based on the corresponding measurement and the motion models computed over a plurality of different control inputs parameters for at least one of the imaging system and the intervention system;computing information metrics for each of the expected belief of system states estimated for the subsequent time step; andselecting the control input parameters to control the at least one of the imaging system and the intervention system for the subsequent time step based on the computed information metrics. 15. A system, comprising: an imaging system to provide image data representing at least a portion of an image space, the image space including at least one of a device and a target within a patient's body;an intervention system comprising intervention controls to control an intervention of the device with respect to the target within the patient's body; anda controller comprising a non-transitory memory storing instructions for an active localization method and a processor to execute the active localization method, the active localization method comprises:estimating a given belief of system state for a given time step, including estimated beliefs of device state and target state, determined from corresponding measurement and motion models computed based on the image data and control input parameters for the given time step;estimating expected beliefs of system state for a subsequent time step based on the estimated given belief of system state and based on the measurement models and the motion models computed over a plurality of different control inputs parameters for at least one of the imaging system and the intervention system; andselecting the control input parameters to actively control the at least one of the imaging system and the intervention system for the subsequent time step according to which of the control input parameters sufficiently maximize an information metric for the subsequent time step based on the expected beliefs of system state,wherein the device comprises a catheter comprising a plurality of multi-axial coils disposed about an elongated body of the catheter and the intervention controls further comprise robotic motion controls that actively control the catheter within the patient's body and actively control application of electrical current to the coils concurrently with application of a magnetic field provided by the imaging system. 16. The system of claim 15, wherein the intervention controls further comprise motion controls that employ Jacobian or inverse kinematics to control at least one state of the device. 17. The system of claim 15, wherein the active localization method further comprises a Bayes filter function to compute at the given belief of system state and the expected beliefs of system state for the subsequent time step. 18. The system of claim 17, wherein the Bayes filter function comprises one of a particle filter function and a Kalman filter function. 19. A system, comprising: a catheter comprising a plurality of coil sets of multi-axial coils disposed about an elongated body of the catheter, at least two of the coil sets including multiple orthogonal coils;a motion control system that employs inverse kinematics and/or Jacobian-based controls to control at least one state of the catheter, the motion control system comprising: motion planning control comprising non-transitory memory that stores instructions and one or more processors to execute the instructions to determine control parameters for adjusting at least one of a position or orientation of the catheter in a three-dimensional coordinate system; andsteering control, which is electrically connected with each of the coil sets, the steering control controlling application of electrical current to each of the coil sets to adjust a position of the catheter in the three-dimensional coordinate system based on the control parameters;an imaging system to provide image data representing at least a portion of an image space, the image space including at least a portion of the catheter that includes the plurality of coil sets, the steering control to apply the current to the coils concurrently with application of a magnetic field from the imaging system to the image space to adjust the position of the catheter in the three-dimensional coordinate system according to the magnetic field and the currentan active localization method executable by the one or more processors, the active localization method programmed to: estimate a given belief of system state for a given time step, including estimated beliefs of device state for the catheter and target state of a target site, determined from corresponding measurement and motion models computed based on the image data and the control parameters for the given time step;estimate expected beliefs of system state for a subsequent time step based on the estimated given belief of system state and based on the measurement models and the motion models computed over a plurality of different control inputs parameters for at least one of the imaging system and the intervention system; andselect the control parameters to actively control the at least one of the imaging system and the motion control system for the subsequent time step according to which of the control input parameters sufficiently maximize an information metric for the subsequent time step based on the expected beliefs of system state. 20. One or more non-transitory computer readable media storing instructions that upon execution execute a method, the method comprising: acquiring image data from an imaging system for a given time step, the image data representing at least one of an instrument and a target within an image space that includes patient anatomy, the imaging system and an intervention system operating according to control input parameters;estimating a given belief of system state for the given time step, the given belief of system state for the given time step including an estimate of instrument state and target state determined from corresponding measurement and motion models computed based on the acquired image data and the control input parameters for the given time step, wherein the estimating the given belief of system state comprises using a Bayes filter function to compute the given belief of system state, the Bayes filter function comprises at least one of a particle filter to estimate a posterior density representing the given belief of system state or a Kalman filter function to estimate a mean and a covariance matrix representing the given belief of system state;estimating an expected belief of system state for a subsequent time step based on the estimated given belief of system state and based on the corresponding measurement and the motion models computed over a plurality of different control inputs parameters for at least one of the imaging system and the intervention system;computing information metrics for each of the expected belief of system states estimated for the subsequent time step; andselecting the control input parameters to control the at least one of the imaging system and the intervention system for the subsequent time step based on the computed information metrics. 21. One or more non-transitory computer readable media storing instructions that upon execution execute a method, the method comprising: acquiring image data from an imaging system for a given time step, the image data representing at least one of an instrument and a target within an image space that includes patient anatomy, the imaging system and an intervention system operating according to control input parameters;estimating a given belief of system state for the given time step, the given belief of system state for the given time step including an estimate of instrument state and target state determined from corresponding measurement and motion models computed based on the acquired image data and the control input parameters for the given time step,wherein the corresponding measurement model comprises:an instrument measurement model to compute a probability density function for the instrument to represent uncertainty in measurements of the instrument by the imaging system; anda target measurement model to compute a probability density function for the target to represent uncertainty in measurements of the instrument by the imaging system; orwherein the corresponding motion model comprises:an instrument motion model to compute a probability density function for the instrument to represent uncertainty in estimating motion of the instrument; anda target motion model to compute a probability density function for the target to represent uncertainty in estimating the motions of the target;estimating an expected belief of system state for a subsequent time step based on the estimated given belief of system state and based on the corresponding measurement and the motion models computed over a plurality of different control inputs parameters for at least one of the imaging system and the intervention system;computing information metrics for each of the expected belief of system states estimated for the subsequent time step; andselecting the control input parameters to control the at least one of the imaging system and the intervention system for the subsequent time step based on the computed information metrics.