Composite microneedle array including nanostructures thereon
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-037/00
A61B-017/20
A61K-009/00
A61K-038/19
A61K-009/70
A61K-038/17
B29C-059/00
B29C-059/02
B29L-031/00
출원번호
US-0382774
(2016-12-19)
등록번호
US-10029084
(2018-07-24)
발명자
/ 주소
Ross, Russell Frederick
출원인 / 주소
Kimberly-Clark Worldwide, Inc.
대리인 / 주소
Dority & Manning, P.A.
인용정보
피인용 횟수 :
0인용 특허 :
122
초록▼
Composite microneedle arrays including microneedles and a film overlaying the microneedles are provided. The film includes a plurality of nano-sized structures fabricated thereon. Devices may be utilized for interacting with a component of the dermal connective tissue. A random or non-random pattern
Composite microneedle arrays including microneedles and a film overlaying the microneedles are provided. The film includes a plurality of nano-sized structures fabricated thereon. Devices may be utilized for interacting with a component of the dermal connective tissue. A random or non-random pattern of structures may be fabricated such as a complex pattern including structures of differing sizes and/or shapes. Devices may be beneficially utilized for delivery of an agent to a cell or tissue. Devices may be utilized to directly or indirectly alter cell behavior through the interaction of a fabricated nanotopography with the plasma membrane of a cell and/or with an extracellular matrix component.
대표청구항▼
1. A composite microneedle array comprising a microneedle assembly that includes a plurality of microneedles; anda film overlaying at least one microneedle of the microneedle assembly, the film having a first surface and a second surface, wherein the first surface of the film is adhered to the micro
1. A composite microneedle array comprising a microneedle assembly that includes a plurality of microneedles; anda film overlaying at least one microneedle of the microneedle assembly, the film having a first surface and a second surface, wherein the first surface of the film is adhered to the microneedle and at least partially conforms thereto, the film comprising a plurality of nanostructures that are arranged in a predetermined pattern on the second surface of the film to project outward from the second surface of the film, and wherein at least a portion of the nanostructures have a cross-sectional dimension of less than 500 nanometers and greater than 5 nanometers, a height of from 10 nanometers to 1 micrometer, and an aspect ratio of from 0.2 to 5. 2. The composite microneedle array according to claim 1, wherein at least one of the microneedles contains a channel along a length of the microneedle. 3. The composite microneedle array according to claim 1, wherein at least a portion of the nanostructures have a cross-sectional dimension of less than 400 nanometers and greater than 10 nanometers. 4. The composite microneedle array according to claim 1, wherein the pattern further comprises microstructures, the nanostructures having a cross-sectional dimension smaller than the microstructures. 5. The composite microneedle array according to claim 4, further comprising second nanostructures having a cross-sectional dimension less than the cross-sectional dimension of the microstructures and greater than the cross-sectional dimension of the first nanostructures. 6. The composite microneedle array according to claim 1, wherein at least a portion of the nanostructures have a height of from 100 nanometers to 700 nanometers. 7. The composite microneedle array according to claim 1, wherein at least a portion of the nanostructures have an aspect ratio of from 0.5 to 3.5. 8. The composite microneedle array of claim 1, wherein at least a portion of the nanostructures have a center-to-center spacing of from 50 nanometers to 1 micrometer. 9. The composite microneedle array of claim 1, wherein the pattern has a fractal dimension of greater than 1 and less than 5. 10. The composite microneedle array of claim 1, wherein at least a portion of the nanostructures have a cross-sectional dimension of from 100 to 300 nanometers. 11. The composite microneedle array of claim 1, wherein the nanostructures have approximately the same cross-sectional dimension. 12. The composite microneedle array of claim 1, wherein the ratio of the cross sectional dimension of two adjacent nanostructures to the center-to-center spacing between those two structures is between 1:1 and 1:4. 13. The composite microneedle array of claim 1, wherein at least a portion of the nanostructures have an equidistant spacing. 14. The composite microneedle array of claim 1, wherein at least a portion of the nanostructures are in the form of pillars. 15. The composite microneedle array of claim 1, wherein the microneedle contains a channel through which a drug compound is capable of flowing. 16. The composite microneedle array of claim 15, wherein the channel has a cross-sectional dimension of from 1 to 100 micrometers. 17. The composite microneedle array of claim 15, wherein the channel has a length of from 10 to 800 micrometers. 18. The composite microneedle array of claim 15, wherein the array contains a base having an aperture, wherein the aperture is in at least partial alignment with the channel of the microneedle. 19. The composite microneedle array of claim 1, wherein the microneedle has a length of from 1 micrometer to 1 millimeter. 20. The composite microneedle array of claim 1, wherein the film exhibits an effective compression modulus between 0.25 MPa and 50 MPa. 21. The composite microneedle array of claim 1, wherein the film exhibits an effective shear modulus between 4 MPa and 320 MPa. 22. The composite microneedle array of claim 1, wherein the second surface of the film exhibits a water contact angle between 80° and 150°. 23. The composite microneedle array of claim 1, wherein the second surface of the film exhibits an average surface roughness between 10 nanometers and 200 nanometers. 24. The composite microneedle array of claim 1, wherein the film is formed from a polymeric material. 25. The composite microneedle array of claim 24, wherein the polymer material includes a polyolefin, polystyrene, polycarbonate, polymethacrylate, polylactide, polyhydroxyalkanoate, or a combination thereof. 26. A transdermal patch comprising a composite microneedle array, which comprises a microneedle assembly that includes a plurality of microneedles; anda film overlaying at least one microneedle of the microneedle assembly, the film having a first surface and a second surface, wherein the first surface of the film is adhered to the microneedle and at least partially conforms thereto, the film comprising a plurality of nanostructures that are arranged in a predetermined pattern on the second surface of the film to project outward from the second surface of the film, and wherein at least a portion of the nanostructures have a cross-sectional dimension of less than 500 nanometers and greater than 5 nanometers, a height of from 10 nanometers to 1 micrometer, and an aspect ratio of from 0.2 to 5. 27. The transdermal patch according to claim 26, further comprising a reservoir for holding a drug compound. 28. The transdermal patch according to claim 27, further comprising a rate control membrane in fluid communication with the reservoir. 29. The transdermal patch according to claim 28, further comprising a release member that is generally impermeable to the drug compound and positioned adjacent to the rate control membrane. 30. The transdermal patch according to claim 27, wherein the drug compound has a molecular weight of greater than 100 kDa and less than 200 kDa. 31. The composite microneedle array of claim 26, wherein the nanostructures have a height of from 100 nanometers to 700 nanometers. 32. A method for forming a composite microneedle array comprising: laying a film over a microneedle assembly, the microneedle assembly including a plurality of microneedles, the film having a first surface and a second surface, the film at least partially conforming to the microneedles, wherein the first surface of the film contacts the microneedle assembly, the second surface of the film comprising a plurality of nanostructures, the nanostructures being arranged in a predetermined pattern to project outward from the second surface of the film, wherein at least a portion of the nanostructures have a cross-sectional dimension of less than 500 nanometers and greater than 5 nanometers, a height of from 10 nanometers to 1 micrometer and an aspect ratio of from 0.2 to 5; andengaging the film with the microneedle assembly such that the film at least partially conforms to the microneedle array and adheres to the microneedle assembly. 33. The method according to claim 32, further comprising forming the structures on the film. 34. The method according to claim 33, wherein the film and the nanostructures are fabricated simultaneously. 35. The method according to claim 33, wherein the structures are fabricated on the film according to a nanoimprint lithography process. 36. The method according to claim 32, wherein the step of engaging the film with the microneedle assembly comprises the application of at least one of heat and pressure to the film. 37. The method according to claim 36, wherein the pressure is a vacuum pressure. 38. The method according to claim 36, wherein the pressure is applied to the second surface of the film. 39. The method according to claim 32, further comprising perforating the film at or near the microneedle tips.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (122)
Frazier,A. Bruno; Andrade,Joseph D.; Bartholomeusz,Daniel A.; Brazzle,John D., Active needle devices with integrated functionality.
Urquhart John (Palo Alto CA) Chandrasekaran Santosh Kumar (Palo Alto CA) Shaw Jane Elizabeth (Atherton CA), Bandage for transdermally administering scopolamine to prevent nausea.
Cho, Dong-il; Paik, Seung Joon; Lim, Jung Min; Lee, Ah Ra; Byun, Sang Won; Koo, Kyo-In, Barb-wired micro needle made of single crystalline silicon and biopsy method and medicine injecting method using the same.
Shah Kishore (Bridgewater NJ) Kydonieus Agis (Kendall Park NJ), Device for controlled release and delivery to mammalian tissue of pharmacologically active agents incorporating a rate c.
Nealey, Paul F.; DePablo, Juan J.; Cerrina, Francesco; Solak, Harun H.; Yang, XiaoMin; Peters, Richard D.; Wang, Qiang, Guided self-assembly of block copolymer films on interferometrically nanopatterned substrates.
Johnson, Peter R.; Emery, Marla R.; Wolter, James T.; Raeder-Devens, Jennifer E.; Duan, Daniel C.; David, Moses M.; Choi, Hye-Ok, Masking method for coating a microneedle array.
Dubrow, Robert S.; Bock, Lawrence A.; Daniels, R. Hugh; Hardev, Veeral D.; Niu, Chunming; Sahi, Vijendra, Medical device applications of nanostructured surfaces.
Suleski, Thomas J., Method and apparatus for fabricating shaped structures and shaped structures including one- , two- or three-dimensional patterns incorporated therein.
Mukerjee, Erik V.; Smith, Rosemary L., Method and/or apparatus for puncturing a surface for extraction, in situ analysis, and/or substance delivery using microneedles.
Sherman, Faiz Feisal; Gartstein, Vladimir, Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation.
Campbell Patricia S. (Palo Alto CA) Enscore David J. (Sunnyvale CA) Gale Robert M. (Los Altos CA) Kaufman Arnold (Palo Alto CA), Method for preventing the formation of a crystalline hydrate in a dispersion of a liquid in a monaqueous matrix.
Van Rijn, Cornelis Johannes Maria; Vogelaar, Laura; Nijdam, Wietze; Barsema, Jonathan Nathaniel; Wessling, Matthias, Method of making a product with a micro or nano sized structure and product.
Delmore, Michael D.; Fleming, Patrick R.; Huntley, Douglas A.; Keister, Jamieson C.; Thomas, Cristina U.; Ferber, Richard H., Microneedle arrays and methods of manufacturing the same.
Laermer, Franz; Stumber, Michael; Scholten, Dick; Maeurer, Christian, Microneedles to be placed in the skin for the transdermal application of pharmaceuticals.
Borenstein, Jeffrey T.; Carter, David; Vacanti, Joseph P., Nanotopographic compositions and methods for cellular organization in tissue engineered structures.
Duerig, Urs T.; Frommer, Jane E.; Gotsmann, Bernd W.; Hedrick, James L.; Knoll, Armin W.; Miller, Robert D.; Pires, David; Wade, Charles G., Patterning nano-scale patterns on a film comprising unzipping polymer chains.
Lothar W. Kleiner ; Robert M. Gale ; Randall G. Berggren ; Gilbert T. Tong ; Guohua Chen ; Keith E. Dionne ; Paul R. Houston, Rate controlling membranes for controlled drug delivery devices.
Osborne James L. (Mountain View CA) Nelson Melinda (Sunnyvale CA) Enscore David J. (Saratoga CA) Yum Su I. (Los Altos CA) Gale Robert M. (Los Altos CA), Subsaturated nicotine transdermal therapeutic system.
Osborne James L. (Mountain View CA) Nelson Melinda (Sunnyvale CA) Enscore David J. (Saratoga CA) Yum Su I. (Los Altos CA) Gale Robert M. (Los Altos CA), Subsaturated nicotine transdermal therapeutic system.
Enscore David J. (Sunnyvale CA) Campbell Patricia S. (Palo Alto CA) Osborne James L. (Mountain View CA) Smart Melinda K. (Sunnyvale CA) Yum Su I. (Los Altos CA), Subsaturated transdermal therapeutic system having improved release characteristics.
Enscore David J. (Sunnyvale CA) Campbell Patricia S. (Palo Alto CA) Osborne James L. (Mountain View CA) Smart Melinda K. (Sunnyvale CA) Yum Su I. (Los Altos CA), Subsaturated transdermal therapeutic system having improved release characteristics.
Enscore David J. (Sunnyvale CA) Campbell Patricia S. (Palo Alto CA) Osborne James L. (Mountain View CA) Smart Melinda K. (Sunnyvale CA) Yum Su I. (Los Altos CA), Subsaturated transdermal therapeutic system having improved release characteristics.
Chandrasekaran Santosh K. (Palo Alto CA) Darda Siegfried (Ingelheim am Rhein CA DEX) Michaels Alan S. (Atherton CA) Cleary Gary W. (Palo Alto CA), Therapeutic system for administering clonidine transdermally.
Gale Robert M. (Los Altos CA) Goetz Victor (Palo Alto CA) Lee Eun S. (Redwood City CA) Taskovich Lina T. (Palo Alto CA) Yum Su I. (Los Altos CA), Transdermal administration of fentanyl and device therefor.
Nabel Elizabeth G. (Ann Arbor MI) Nabel Gary J. (Ann Arbor MI), Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.