[특허]Mesenchymal stem cells for the treatment of CNS diseases

[미국특허] Mesenchymal stem cells for the treatment of CNS diseases 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/18 C12N-005/0775 A61K-035/28 C12N-005/077 C12N-005/079 A61K-035/12
출원번호	US-0261959 (2016-09-11)
등록번호	US-10052363 (2018-08-21)
발명자 / 주소	Kadouri, Avinoam Bar-Ilan, Avihay Melamed, Eldad Offen, Daniel Sadan, Ofer Bahat-Stromza, Merav
출원인 / 주소	Ramot at Tel-Aviv University Ltd.
인용정보	피인용 횟수 : 0 인용 특허 : 14

초록 ▼

An isolated human cell is disclosed comprising at least one mesenchymal stem cell phenotype and secreting brain-derived neurotrophic factor (BDNF), wherein a basal secretion of the BDNF is at least five times greater than a basal secretion of the BDNF in a mesenchymal stem cell. Methods of generatin

대표청구항 ▼

1. A method of treating a neurodegenerative disorder comprising administering to the central nervous system of an individual in need thereof a therapeutically effective amount of non-genetically modified human cells which express at least one mesenchymal stem cell marker and secrete brain-derived neurotrophic factor (BDNF) and glial derived neurotrophic factor (GDNF), and do not secrete nerve growth factor (bNGF), wherein said at least one mesenchymal stem cell marker is selected from the group consisting of CD73, CD90 and CD105, wherein a basal secretion of said GDNF in the cells is at least two times greater than a basal secretion of said GDNF in non-differentiated, non-genetically modified human mesenchymal stem cells, wherein the neurodegenerative disease is selected from the group consisting of Parkinson's Disease, amyotrophic lateral sclerosis (ALS) and Huntington's disease, wherein said non-genetically modified human cells are differentiated ex vivo from bone marrow derived mesenchymal stem cells. 2. The method of claim 1, wherein said non-genetically modified human cells further express at least one additional neurotrophic factor. 3. The method of claim 2, wherein said at least one additional neurotrophic factor is selected from the group consisting of neurotrophin-3 (NT-3), neurotrophin-4/5, neurturin (NTN), persephin, artemin (ART), ciliary neurotrophic factor (CNTF), insulin growth factor-I (IGF-1) and neublastin. 4. The method of claim 1, wherein said non-genetically modified human cells take up at least ten times more glutamate from their surroundings than non-differentiated, non-genetically modified mesenchymal stem cells. 5. The method of claim 1, wherein said non-genetically modified human cells are autologous to said subject. 6. The method of claim 1, wherein said non-genetically modified human cells are non-autologous to said subject. 7. The method of claim 1, wherein said non-genetically modified human cells are allogeneic to said subject.

이 특허에 인용된 특허 (14) 인용/피인용 타임라인 분석

Sanchez-Ramos, Juan; Song, Shijie; Janssen, William; Sanberg, Paul; Freeman, Thomas, Bone marrow cells as a source of neurons for brain and spinal cord repair.
상세보기
Barde Yves-Alain (Graefelfing DEX) Leibrock Joachim (Pfungstadt DEX) Lottspeich Friedrich (Neuried DEX) Edgar David (Liverpool NY GB2) Yancopoulos George (Briarcliff Manor NY) Thoenen Hans (Munich DE, Brain derived neurotrophic factor.
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Capecchi Mario R. (Salt Lake City UT) Thomas Kirk R. (Salt Lake City UT), Cells and non-human organisms containing predetermined genomic modifications and positive-negative selection methods and.
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Potter Huntington, Compounds and methods for inhibiting .beta.-protein filament formation and neurotoxicity.
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Carpenter Melissa, Human CNS neural stem cells.
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Offen, Daniel; Bahat-Stromza, Merav; Melamed, Eldad, Isolated cells and populations comprising same for the treatment of CNS diseases.
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Kadouri, Avinoam; Bar-Ilan, Avihay; Melamed, Eldad; Offen, Daniel; Sadan, Ofer; Bahat-Stromza, Merav, Mesenchymal stem cells for the treatment of CNS diseases.
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Kadouri, Avinoam; Bar-Ilan, Avihay; Melamed, Eldad; Offen, Daniel; Sadan, Ofer; Bahat-Stromza, Merav, Mesenchymal stem cells for the treatment of CNS diseases.
상세보기
Kadouri, Avinoam; Bar-Ilan, Avihay; Melamed, Eldad; Offen, Daniel; Sadan, Ofer; Bahat-Stromza, Merav, Mesenchymal stem cells for the treatment of CNS diseases.
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Gold, Joseph D.; Lebkowski, Jane S., Methods for providing differentiated stem cells.
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Suzuki Takao,JPX ; Sakurai Fusayoshi,JPX ; Ueno Haruo,JPX ; Shibuya Tomohiro,JPX, Photosensitive elastomer composition and photosensitive rubber plate.
상세보기
Capecchi Mario R. (Salt Lake City UT) Thomas Kirk R. (Salt Lake City UT), Positive-negative selection methods and vectors.
상세보기
Dezawa,Mari; Sawada,Hajime; Takano,Masahiko, Schwann cells originating in myeloid interstitial cells.
상세보기
Tennekoon, Gihan; Coyle, Andrew J.; Grinspan, Judith; Beesley, Jackie S., Therapeutic uses for mesenchymal stromal cells.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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[미국특허] Mesenchymal stem cells for the treatment of CNS diseases 원문보기