초록 ▼

A tunable antimicrobial-loaded hydrogel formulation has a mechanical strength can be altered by changing the salt composition. The hydrogel formulation is preferably a Gellan film. The ion concentration in the gel material may be altered to obtain the desired gel strength. The hydrogel formulation i

A tunable antimicrobial-loaded hydrogel formulation has a mechanical strength can be altered by changing the salt composition. The hydrogel formulation is preferably a Gellan film. The ion concentration in the gel material may be altered to obtain the desired gel strength. The hydrogel formulation is layered directly upon a skin area such as burnt skin. The hydrogel formulation includes a dosage of free antibiotic, such as the antibiotic is preferably vancomycin, for rapid release. The hydrogel formulation also includes microparticles and/or nanoparticles such as activated carbon powder that has adsorbed additional antibiotic. The particles are used to aid in attaining a timely or sustained release of the antibiotic drug.

대표청구항 ▼

1. A hydrogel formulation comprising: a hydrogel having a particular mechanical strength;a salt composition for altering the mechanical strength; anda plurality of porous activated carbon powder nanoparticles comprising an adsorbed dosage of an antibiotic, said plurality of porous activated carbon n

1. A hydrogel formulation comprising: a hydrogel having a particular mechanical strength;a salt composition for altering the mechanical strength; anda plurality of porous activated carbon powder nanoparticles comprising an adsorbed dosage of an antibiotic, said plurality of porous activated carbon nanoparticles embedded between a microporous structure of the hydrogel and said porous activated carbon nanoparticles facilitating the sustained release of the absorbed dosage of antibiotic. 2. The hydrogel formulation of claim 1, wherein the hydrogel is a Gellan film. 3. The hydrogel formulation of claim 1, wherein the dosage of absorbed antibiotic is vancomycin. 4. The hydrogel formulation of claim 1, further comprising a dosage of free antibiotic. 5. The hydrogel of claim 4, wherein the dosage of free antibiotic and the adsorbed dosage of antibiotic are both vancomycin. 6. The hydrogel of claim 1, wherein the porous activated carbon powder nanoparticles comprise micropores, mesopores, and macropores. 7. The hydrogel formulation of claim 1, further comprising a compound selected from the group consisting of an antibiotic, an antifungal compound, an anti-inflammatory compound, a proteins and enzymes to promote wound healing, hemostatic agents, diagnostic and contrast agents, extracellular matrix components, and combinations thereof. 8. A tunable antimicrobial-loaded hydrogel formulation comprising: a hydrogel having a pH level, wherein the hydrogel is a Gellan film;a salt composition in the hydrogel for setting the pH level;a first dosage of free antibiotic in the hydrogel; anda plurality of porous activated carbon powder nanoparticles in the hydrogel, the porous activated carbon powder nanoparticles facilitating a sustained release of a second dosage of antibiotic adsorbed in the activated carbon nanoparticles. 9. The hydrogel formulation of claim 8, wherein the dosage of absorbed antibiotic is vancomycin. 10. The hydrogel of claim 8, wherein the dosage of free antibiotic and the adsorbed dosage of antibiotic are both vancomycin. 11. The hydrogel of claim 8, wherein the porous activated carbon powder nanoparticles comprise micropores, mesopores, and macropores. 12. A method for treating burnt skin comprising the steps of: layering a hydrogel formulation directly upon the burnt skin, the hydrogel formulation comprising: a hydrogel having a particular mechanical strength;a salt composition for altering the mechanical strength; anda plurality of porous activated carbon powder nanoparticles comprising an adsorbed dosage of an antibiotic, said plurality of porous activated carbon powder nanoparticles embedded between a microporous structure of the hydrogel and said porous activated carbon powder nanoparticles facilitating the sustained release of the absorbed dosage of antibiotic. 13. The method of claim 12, wherein the hydrogel is a Gellan film. 14. The method of claim 12, wherein the dosage of absorbed antibiotic is vancomycin. 15. The method of claim 12, further comprising a dosage of free antibiotic. 16. The method of claim 15, wherein the dosage of free antibiotic and the adsorbed dosage of antibiotic are both vancomycin. 17. The method of claim 12, wherein the porous activated carbon powder nanoparticles comprise micropores, mesopores, and macropores. 18. The method of claim 12, further comprising a compound selected from the group consisting of an antibiotic, an antifungal compound, an anti-inflammatory compound, a proteins and enzymes to promote wound healing, hemostatic agents, diagnostic and contrast agents, extracellular matrix components, and combinations thereof.