Liquid mixing device, and liquid chromatography apparatus
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-030/34
G01N-030/24
B01D-015/12
B01F-005/06
B01F-015/00
G01N-030/16
B01F-013/00
B81C-001/00
출원번호
US-0028492
(2014-12-19)
등록번호
US-10088459
(2018-10-02)
우선권정보
JP-2014-002078 (2014-01-09)
국제출원번호
PCT/JP2014/083704
(2014-12-19)
국제공개번호
WO2015/104976
(2015-07-16)
발명자
/ 주소
Onoda, Yugo
Tomida, Shoji
Sugimoto, Kouichi
Yagi, Takashi
Watanabe, Tetsuya
출원인 / 주소
Hitachi High-Technologies Corporation
대리인 / 주소
Crowell & Moring LLP
인용정보
피인용 횟수 :
0인용 특허 :
13
초록▼
A liquid-mixing device that minimizes solvent leakage and reduces creep of or damage to the component parts of said liquid-mixing device even at ultrahigh pressures of 100 MPa and up. Also, a liquid chromatography device using said liquid-mixing device. Said liquid chromatography device is provided
A liquid-mixing device that minimizes solvent leakage and reduces creep of or damage to the component parts of said liquid-mixing device even at ultrahigh pressures of 100 MPa and up. Also, a liquid chromatography device using said liquid-mixing device. Said liquid chromatography device is provided with a supply pump that supplies a plurality of different solutions, a liquid-mixing device that mixes the supplied solutions, a sample injection device that injects a sample into the mixture of solutions, a column that separates the components of the injected sample, and a detector that detects the separated components. The liquid-mixing device has an inlet-side connector through which the plurality of different solutions flow in, a liquid-mixing section in which said solutions are mixed, and an outflow-side connector through which the mixed solutions flow out. The inlet-side connector and the liquid-mixing section are directly bonded to each other via diffusion bonding, as are the liquid-mixing section and the exit-side connector.
대표청구항▼
1. A liquid chromatography apparatus, comprising: a feed pump configured to feed a plurality of solutions;a liquid mixing device configured to mix the solutions fed by the feed pump;a sample injection device configured to inject a sample in the solutions mixed in the liquid mixing device;a column co
1. A liquid chromatography apparatus, comprising: a feed pump configured to feed a plurality of solutions;a liquid mixing device configured to mix the solutions fed by the feed pump;a sample injection device configured to inject a sample in the solutions mixed in the liquid mixing device;a column configured to separate components of the sample injected by the sample injection device; anda detector configured to detect the components separated in the column, wherein:the liquid mixing device includes an inlet side connector portion having, on a first axial end thereof, a first hollow shape that allows a first pipe to be connected to the feed pump so that the plurality of solutions fed by the feed pump flow into the inlet side connector portion, a liquid mixing portion configured to mix the solutions that have flowed into the inlet side connector portion, and an outlet side connector portion having, on a first axial end thereof, a second hollow shape that allows a second pipe to be connected to the sample injection device so that the solutions mixed in the liquid mixing portion flow into the sample injection device;a second axial end of the inlet side connector portion that is opposite to the first axial end of the inlet side connector portion is directly diffusion bonded to the liquid mixing portion;a second axial end of the outlet side connector portion that is opposite to the first axial end of the outlet side connector portion is directly diffusion bonded to the liquid mixing portion,the first hollow shape and the second hollow shape are disposed on opposite sides of an imaginary line passing through a center of the inlet side connector portion and the outlet side connector portion,the liquid mixing portion includes a plurality of laminated structures arranged one behind the other from a region of the liquid mixing portion adjacent to the first hollow shape to a region of the liquid mixing portion adjacent to the second hollow shape, anda groove shape of the liquid mixing portion includes a spider-web shape and at least another shape selected from the group consisting of a swirl, a plus sign, and a square. 2. The liquid chromatography apparatus according to claim 1, wherein: a third hollow shape is provided on the second axial end of the inlet side connector portion; anda fourth hollow shape is provided on the second axial end of the outlet side connector portion. 3. A liquid chromatography apparatus, comprising: a liquid mixing device configured to mix a plurality of solutions;a feed pump configured to feed the solutions mixed in the liquid mixing device;a sample injection device configured to inject a sample in the solutions fed by the feed pump;a column configured to separate components of the sample injected by the sample injection device; anda detector configured to detect the components separated in the column, wherein:the liquid mixing device includes an inlet side connector portion having, on a first axial end thereof, a first hollow shape that allows a first pipe to be connected to the plurality of solutions so that the plurality of solutions flow into the inlet side connector portion, a liquid mixing portion configured to mix the solutions that have flowed into the inlet side connector portion, and an outlet side connector portion having, on a first axial end thereof, a second hollow shape that allows a second pipe to be connected to the feed pump so that the solutions mixed in the liquid mixing portion flow into the feed pump;a second axial end of the inlet side connector portion that is opposite to the first axial end of the inlet side connector portion is directly diffusion bonded to the liquid mixing portion;a second axial end of the outlet side connector portion that is opposite to the first axial end of the outlet side connector portion is directly diffusion bonded to the liquid mixing portion,the first hollow shape and the second hollow shape are disposed on opposite sides of an imaginary line passing through a center of the inlet side connector portion and the outlet side connector portion,the liquid mixing portion includes a plurality of laminated structures arranged one behind the other from a region of the liquid mixing portion adjacent to the first hollow shape to a region of the liquid mixing portion adjacent to the second hollow shape, anda groove shape of the liquid mixing portion includes a spider-web shape and at least another shape selected from the group consisting of a swirl, a plus sign, and a square. 4. The liquid chromatography apparatus according to claim 3, wherein: a third hollow shape is provided on the second axial end of the inlet side connector portion; anda fourth hollow shape is provided on the second axial end of the outlet side connector portion. 5. A liquid mixing device for a liquid chromatography apparatus, comprising: an inlet side connector portion having, on a first axial end thereof, a first hollow shape configured to connect a first pipe so that the plurality of solutions flow into the inlet side connector portion;a liquid mixing portion configured to mix the solutions that have flowed into the inlet side connector portion; andan outlet side connector portion having, on a firstaxial end thereof, a second hollow shape configured to connect a second pipe so that the solutions mixed in the liquid mixing portion flow downstream, wherein a second axial end of the inlet side connector portion that is opposite to the first axial end of the inlet side connector portion is directly diffusion bonded to the liquid mixing portion,a second axial end of the outlet side connector portion that is opposite to the first axial end of the outlet side connector portion is directly diffusion bonded to the liquid mixing portion,the first hollow shape and the second hollow shape are disposed on opposite sides of an imaginary line passing through a center of the inlet side connector portion and the outlet side connector portion,the liquid mixing portion includes a plurality of laminated structures arranged one behind the other from a region of the liquid mixing portion adjacent to the first hollow shape to a region of the liquid mixing portion adjacent to the second hollow shape, anda groove shape of the liquid mixing portion includes a spider-web shape and at least another shape selected from the group consisting of a swirl, a plus sign, and a square. 6. The liquid mixing device according to claim 5, wherein a third hollow shape is provided on the second axial end of the inlet side connector portion; anda fourth hollow shape is provided on the second axial end of the outlet side connector portion.
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