IPC분류정보
국가/구분 |
United States(US) Patent
등록
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국제특허분류(IPC7판) |
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출원번호 |
US-0803083
(2010-06-18)
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등록번호 |
US-10091985
(2018-10-09)
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발명자
/ 주소 |
- Tempelman, Linda A.
- Papas, Klearchos K.
- Stone, Simon G.
- Scott, III, William Earl
- Suszynski, Thomas M.
- Matsumoto, Shuichiro
- Fabrega, Joana Ferrer
- Rizzari, Michael D.
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 |
피인용 횟수 :
1 인용 특허 :
28 |
초록
▼
Method and system for organ preservation. According to one aspect, an organ may be preserved by being perfused with an in situ generated preserving gas. The organ may be, for example, a human or porcine pancreas, and perfusion of the pancreas may be anterograde, retrograde, ductal, anterograde/ducta
Method and system for organ preservation. According to one aspect, an organ may be preserved by being perfused with an in situ generated preserving gas. The organ may be, for example, a human or porcine pancreas, and perfusion of the pancreas may be anterograde, retrograde, ductal, anterograde/ductal, or retrograde/ductal. The preserving gas used to perfuse the organ may be dissolved in a liquid and then administered to the organ as a gas/liquid solution or may be mixed with one or more other gases and then administered to the organ as a gas/gas mixture. The preserving gas may be, for example, oxygen gas generated in situ using an electrochemical oxygen concentrator. According to another aspect, an organ preservation system may include an electrochemical oxygen concentrator having a water vapor feed, as well as auxiliary equipment to control and measure delivery pressure, flow, temperature and humidity.
대표청구항
▼
1. A method of preserving at least one organ ex vivo, said method comprising the steps of: (a) generating in situ at least two preserving gases, wherein the at least two preserving gases comprise hydrogen gas and oxygen gas; and(b) persufflating the at least one organ ex vivo with each of the in sit
1. A method of preserving at least one organ ex vivo, said method comprising the steps of: (a) generating in situ at least two preserving gases, wherein the at least two preserving gases comprise hydrogen gas and oxygen gas; and(b) persufflating the at least one organ ex vivo with each of the in situ generated preserving gases. 2. The method as claimed in claim 1 wherein the at least one organ is a human organ. 3. The method as claimed in claim 2 wherein the at least one organ is a pancreas. 4. The method as claimed in claim 3 wherein the at least one organ is a human pancreas. 5. The method as claimed in claim 3 wherein the at least one organ is a porcine pancreas. 6. The method as claimed in claim 1 wherein the at least one organ is a porcine organ. 7. The method as claimed in claim 1 wherein the at least one organ is selected from the group consisting of the pancreas, the liver, the kidney, the heart, the lung, and the small intestine. 8. The method as claimed in claim 1 further comprising the step of mixing at least one of the preserving gases generated in step (a) in one or more gases to form a gas/gas mixture and wherein said persufflation step comprises persufflating the at least one organ with said gas/gas mixture. 9. The method as claimed in claim 1 wherein the at least two preserving gases further comprise gaseous carbon dioxide, gaseous carbon monoxide, and water vapor. 10. The method as claimed in claim 1 wherein said step for in situ generating the at least two preserving gases is performed electrochemically. 11. The method as claimed in claim 10 wherein said step for in situ generating the at least two preserving gases is performed using an electrolyzer. 12. The method as claimed in claim 1 wherein said step for in situ generating the oxygen gas is performed using an electrochemical oxygen concentrator. 13. The method as claimed in claim 1 wherein said step for in situ generating a preserving gas is performed by pressure swing adsorption. 14. The method as claimed in claim 1 wherein said step for in situ generating a preserving gas is performed by chemical oxygen release. 15. The method as claimed in claim 1 wherein the at least one organ is a pancreas, said method further comprising the step of mixing the in situ generated oxygen gas in ambient air to form a gas/gas mixture and wherein said persufflating step comprises persufflating the at least one organ with said gas/gas mixture. 16. The method as claimed in claim 15 wherein said gas/gas mixture has an oxygen concentration of at least approximately 20% and less than 100%. 17. The method as claimed in claim 16 wherein said gas/gas mixture has an oxygen concentration of approximately 30-80%. 18. The method as claimed in claim 17 wherein said gas/gas mixture has an oxygen concentration of approximately 40%. 19. The method as claimed in claim 15 wherein said gas/gas mixture has an oxygen concentration of approximately 40% and wherein said persufflating step comprises persufflating the at least one organ with said gas/gas mixture at a flow rate of about 15-22 cc/min and at a pressure of less than about 22 mm Hg. 20. The method as claimed in claim 19 wherein said gas/gas mixture has a temperature of about 4-8° C. at the time of persufflating the at least one organ. 21. The method as claimed in claim 1 wherein the at least one organ is a plurality of organs and wherein said persufflating step comprises persufflating the plurality of organs simultaneously. 22. The method as claimed in claim 1 further comprising the step of bathing the organ in an organ preservation solution and wherein the persufflating step is performed during said bathing step. 23. A method of pancreas preservation, said method comprising: (a) generating in situ gaseous oxygen;(b) mixing the in situ gaseous oxygen with ambient air to produce a preserving gas;(c) persufflating the pancreas with the preserving gas;(d) wherein, during said mixing step, the relative proportions of gaseous oxygen and ambient air in the preserving gas are controlled to obtain a desired oxygen concentration in the preserving gas. 24. The method as claimed in claim 23 wherein said persufflating step comprises persufflating, via cannulation, the pancreas with the preserving gas. 25. The method as claimed in claim 24 wherein the pancreas is a human pancreas. 26. The method as claimed in claim 25 wherein said persufflating step comprises persufflating the pancreas anterograde via cannulation of at least one artery. 27. The method as claimed in claim 26 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with division of aorta to include celiac trunk and superior mesenteric artery. 28. The method as claimed in claim 26 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with direct cannulation of celiac trunk and superior mesenteric artery. 29. The method as claimed in claim 26 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with direct cannulation of proximal splenic artery and superior mesenteric artery. 30. The method as claimed in claim 25 wherein said persufflating step comprises persufflating the pancreas retrograde via cannulation of at least one vein. 31. The method as claimed in claim 30 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with cannulation of inferior mesenteric vein or splenic vein. 32. The method as claimed in claim 30 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with cannulation of superior mesenteric vein. 33. The method as claimed in claim 30 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with cannulation of portal vein. 34. The method as claimed in claim 25 wherein said persufflating step comprises persufflating the human pancreas through at least one ductal entry. 35. The method as claimed in claim 25 wherein said persufflating step comprises persufflating the human pancreas both through at least one ductal entry and through at least one artery. 36. The method as claimed in claim 25 wherein said persufflating step comprises persufflating the human pancreas both through at least one ductal entry and through at least one vein. 37. The method as claimed in claim 24 wherein the pancreas is a porcine pancreas. 38. The method as claimed in claim 37 wherein said persufflating step comprises persufflating the pancreas anterograde via cannulation of at least one artery. 39. The method as claimed in claim 38 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with division of aorta to include celiac trunk and superior mesenteric artery. 40. The method as claimed in claim 38 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with direct cannulation of celiac trunk and superior mesenteric artery. 41. The method as claimed in claim 38 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with direct cannulation of proximal splenic artery and superior mesenteric artery. 42. The method as claimed in claim 37 wherein said persufflating step comprises persufflating the pancreas retrograde via cannulation of at least one vein. 43. The method as claimed in claim 42 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with cannulation of splenic vein. 44. The method as claimed in claim 43 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with cannulation of superior mesenteric vein. 45. The method as claimed in claim 42 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with cannulation of inferior mesenteric vein. 46. The method as claimed in claim 42 wherein said cannulation comprises en bloc pancreaticoduodenectomy and/or splenectomy with cannulation of portal vein. 47. The method as claimed in claim 37 wherein said persufflating step comprises persufflating the porcine pancreas through at least one ductal entry. 48. The method as claimed in claim 37 wherein said persufflating step comprises persufflating the porcine pancreas both through at least one ductal entry and through at least one artery. 49. The method as claimed in claim 37 wherein said persufflating step comprises persufflating the porcine pancreas both through at least one ductal entry and through at least one vein. 50. The method as claimed in claim 23 wherein said step for in situ generating gaseous oxygen is performed electrochemically. 51. A method of preserving at least one organ, said method comprising: (a) generating in situ gaseous oxygen;(b) mixing the gaseous oxygen with ambient air to form a preserving gas;(c) persufflating the at least one organ with the preserving gas;(d) wherein, during said mixing step, the relative proportions of gaseous oxygen and ambient air in the preserving gas are controlled to obtain a desired oxygen concentration in the preserving gas.
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