[특허]Corneal implant systems and methods

Corneal implant systems and methods 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-009/00 A61F-002/14 A61F-009/008
출원번호	US-0152425 (2014-01-10)
등록번호	US-10092393 (2018-10-09)
발명자 / 주소	Muller, David
출원인 / 주소	Allotex, Inc.
대리인 / 주소	McDonnell Boehnen Hulbert & Berghoff LLP
인용정보	피인용 횟수 : 0 인용 특허 : 49

초록 ▼

According to one aspect of the present disclosure, an implant for correcting vision impairment is disclosed. The implant is made from a donor corneal tissue sized and shaped to provide a predetermined refractive correction and reshaping of a cornea. The donor corneal tissue includes a posterior surface and an anterior surface. The posterior surface has a surface profile that is configured to generally correspond to a shape of an implantation site of the cornea.

대표청구항 ▼

1. A method of making an implant for correcting vision impairment, comprising: receiving a donor corneal tissue, the donor corneal tissue including stromal tissue between an anterior surface and a posterior surface;cutting a plurality of lamellar sheets from the stromal tissue, wherein cuts are made between the posterior surface and the anterior surface and parallel to the posterior surface or the anterior surface to define surfaces of the lamellar sheets, and the lamellar sheets are defined by lamellar layers in the stromal tissue, parallel to the posterior surface or the anterior surface;cutting a plurality of lenticules from the lamellar sheets; andselecting at least one of the lenticules to be reshaped to form an implant having a shape and size configured for a predetermined refractive correction. 2. The method of claim 1, further comprising reshaping the at least one of the lenticules to form an implant having a shape and size configured for a predetermined refractive correction. 3. The method of claim 2, wherein the at least one of the lenticules is reshaped prior to the lenticule being cut from the lamellar sheets. 4. The method of claim 2, wherein the reshaping includes reshaping a surface of the at least one of the lenticules to have a profile based on a surface profile of an implantation site of a cornea. 5. The method of claim 1, wherein the lamellar sheets are cut from the stromal tissue by a femtosecond laser. 6. The method of claim 2, wherein the at least one of the lenticules is reshaped to form the implant using an excimer laser. 7. The method of claim 1, wherein the cutting the lamellar sheets from the stromal tissue is performed in a controlled environment that maintains the implant at a state of hydration that generally corresponds to a state of hydration of a recipient cornea. 8. The method of claim 1, wherein selecting at least one of the lenticules includes selecting a plurality of the lenticules to be reshaped to form a plurality of implants, wherein the plurality of implants are configured to provide a plurality of different refractive corrections. 9. The method of claim 1, further comprising: engaging the donor corneal tissue with a first engagement device, the lamellar sheets being cut from the stromal tissue while the donor corneal tissue engages the first engagement device; andafter the cutting of each lamellar sheet from the stromal tissue, transferring the lamellar sheet from the first engagement device to a second engagement device, one or more of the lenticules being cut from the lamellar sheet while the lamellar sheet is engaged by the second engagement device. 10. The method of claim 9, wherein the first engagement device includes a first engagement surface for engaging the donor corneal tissue, the first engagement surface includes a cavity and the first engagement device is configured to apply a vacuum pressure to the donor corneal tissue to capture a portion of the donor corneal tissue within the cavity while the lamellar sheets are cut from the stromal tissue. 11. The method of claim 10, wherein the vacuum pressure is applied to the donor corneal tissue via a fluid in contact with the donor corneal tissue. 12. The method of claim 9, further comprising applanating the donor corneal tissue using the first engagement device while the lamellar sheets are cut from the stromal tissue. 13. The method of claim 2, further comprising determining the topography of a cornea, the plurality of lenticules being cut from the lamellar sheets and the at least one of the lenticules being reshaped to form the implant based on the determined topography of the cornea. 14. The method of claim 1, further comprising applying a cross-linking agent to the donor corneal tissue and activating the cross-linking agent to strengthen the donor corneal tissue. 15. The method of claim 1, further comprising sterilizing the implant.

이 특허에 인용된 특허 (49)

Peyman, Gholam A., Ablatable intracorneal inlay with predetermined refractive properties.
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Raksi, Ferenc; Juhasz, Tibor, Adaptive patient interface.
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Gholam A. Peyman, Adjustable universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith.
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Holliday, Keith; Lang, Alan, Corneal inlay design and methods of correcting vision.
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Barrett Graham D. (Perth CA AUX) Link William J. (Irvine CA) Reich Cary J. (Laguna Hills CA), Corneal inlay lenses.
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Marmo, J. Christopher, Corneal onlays and wavefront aberration correction to enhance vision.
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Lieberman David M. (300 E. 51st St. ; Apt. 18B New York NY 10022), Corneal punch and method of use.
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Swinger Casimir A. (9 W. 67th St. New York NY 10023), Corneal surgery using laser, donor corneal tissue and synthetic material.
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Raksi, Ferenc; Juhasz, Tibor; Kurtz, Ron; Lummis, Wes; Davis, Chris; Nagy, Laszlo, Disposable patient interface.
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Marmo, J. Christopher; Back, Arthur; Hollrigel, Greg S., Inserting lenses into corneal epithelial pockets to improve vision.
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Dishler, Jon; Schneider, Ned; Le, Alan Ngoc, Insertion system for corneal implants.
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Dishler, Jon; Schneider, Ned; Le, Alan Ngoc, Insertion system for corneal implants.
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Zickler, Leander; Catlin, Scott J.; Pang, Andrew Y, Intracorneal inlay, system, and method.
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Peyman Gholam A., Intrastromal corneal modification.
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Juhasz Tibor ; Bille Josef F.,DEX, Intrastromal photorefractive keratectomy.
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Lai Shui T. (Encinitas CA), Method and apparatus for ophthalmic surgery.
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Degani, Asaf; Gellatly, Andrew W., Method and system for designing, analysing and specifying a human-machine interface.
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Gerard Mourou ; Detao Du ; Subrata K. Dutta ; Victor Elner ; Ron Kurtz ; Paul R. Lichter ; Xinbing Liu ; Peter P. Pronko ; Jeffrey A. Squier, Method for controlling configuration of laser induced breakdown and ablation.
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Apter, Robert; Apter, Alain, Method for determining the configuration of an ophthalmic lens, ophthalmic lens produced according to said method, and method for producing said lens.
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Cumming J. Stuart (Anaheim CA) Fosberg J. Roberts (S. Laguna CA), Method for preparing corneal donor tissue for refractive eye surgery.
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Richter Jacob (Ramat Hasharon ILX) Pinchasik Gregory (Ramat Hasharon ILX) Yaron Ira (Har Adar ILX), Method of implanting an intraocular implant.
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Dishler, Jon; Miller, Troy A.; Vatz, Alexander; Alexander, James R., Method of using small diameter intracorneal inlays to treat visual impairment.
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Lai Shui T., Method of, and apparatus for, surgery of the cornea.
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Mata, Nathan L.; Phan, Kim B.; Bui, Tam V.; Haddach, Mustapha, Methods and compounds for treating retinol-related diseases.
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Dishler, Jon; Schneider, Ned, Methods and devices for forming corneal channels.
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Chernyak,Dimitri, Methods and systems for tracking a torsional orientation and position of an eye.
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Perez,Edward, Methods for producing epithelial flaps on the cornea and for placement of ocular devices and lenses beneath an epithelial flap or membrane, epithelial delaminating devices, and structures of epithelium and ocular devices and lenses.
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Bille Josef F. (Solana Beach CA) Brown Stuart I. (La Jolla CA), Multiwavelength laser source.
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Swinger Casimir A. ; Lai Shui T., Ophthalmic surgical laser and method.
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Rathjen, Christian, Ophthalmological patient interface device.
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Peyman Gholam A. (535 N. Michigan Ave. Chicago IL 60611) Koziol Jeffrey E. (601 W. Central Mount Prospect IL 60056), Optical assembly permanently attached to the cornea.
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Khadem John (Chicago IL) Truong Toan V. (Anaheim Hills CA), Organic tissue glue for closure of wounds.
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Redmond, Robert W.; Kochevar, Irene E., Photochemical tissue bonding.
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Perez, Edward, Pre-fabricated corneal tissue lens method of corneal overlay to correct vision.
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Klopotek Peter J., Surgical microtomes.
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Nigam, Alok, System for packaging and handling an implant and method of use.
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Nigam, Alok, System for packaging and handling an implant and method of use.
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Peyman Gholam A., Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith.
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Peyman Gholam A., Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith.
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Peyman Gholam A., Universal implant blank for modifying corneal curvature and methods of modifying corneal curvature therewith.
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