Apparatus and methods for delivering therapeutic agents
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-009/00
A61M-031/00
출원번호
US-0931007
(2013-06-28)
등록번호
US-10117774
(2018-11-06)
발명자
/ 주소
Humayun, Mark S.
Caffey, Sean
출원인 / 주소
UNIVERSITY OF SOUTHERN CALIFORNIA
대리인 / 주소
Morgan, Lewis & Bockius LLP
인용정보
피인용 횟수 :
0인용 특허 :
172
초록
In various embodiments, a drug-delivery device includes one or more reservoirs that may each contain a therapeutic agent for delivery to a patient.
대표청구항▼
1. A drug-delivery device, comprising: a first reservoir for containing a first liquid that comprises or consists essentially of a first therapeutic agent;a second reservoir for containing a second liquid that comprises or consists essentially of a second therapeutic agent different from the first t
1. A drug-delivery device, comprising: a first reservoir for containing a first liquid that comprises or consists essentially of a first therapeutic agent;a second reservoir for containing a second liquid that comprises or consists essentially of a second therapeutic agent different from the first therapeutic agent; anda cannula having first, second and third portions, the second and third portions branching off from the first portion to communicate fluidically with the first and second reservoirs, respectively;a first fluid-flow isolation structure located in the second portion;a second fluid-flow isolation structure located in the third portion;memory for storing a drug-delivery regimen;a microprocessor for controlling a delivery of the first and second liquids to a patient through the cannula based on an execution of the stored drug-delivery regimen; anda sensor for detecting a measured eye pressure for the patient;wherein the first and second fluid-flow isolation structures prevent fluidic communication between the first and second reservoirs and isolate the first and second reservoirs from an external environment. 2. The drug-delivery device of claim 1, wherein each of the first and second therapeutic agents treats at least one of age-related macular degeneration, macular edema associated with diabetic retinopathy, or macular edema associated with retinovascular occlusive diseases. 3. The drug-delivery device of claim 1, wherein each of the first and second therapeutic agents is selected from the group consisting of ranibizumab, pegaptanib, verteporfin, bevacizumab, a steroid, a drug that prevents beta amyloid deposition in the retina, an anti-human complement activation blocker that blocks complement H activation in the eye, and siRNA molecules. 4. The drug-delivery device of claim 1, wherein the first and second therapeutic agents treat two different maladies selected from the group consisting of glaucoma, ocular hypertension, age-related macular degeneration, macular edema associated with diabetic retinopathy, macular edema associated with retinovascular occlusive diseases, low tear production, cytomegalovirus retinitis, bacterial conjunctivitis, itching and allergic conjunctivitis, post-operative eye inflammation, inflammation of the cornea due to herpes simplex virus, postoperative inflammation after cataract extraction, corneal ulcers, and Sjögren's syndrome. 5. The drug-delivery device of claim 1, further comprising first and second pumps for delivering the first and second liquids to the patient, respectively, wherein the microprocessor issues instructions to actuate the first pump separately from the second pump. 6. The drug-delivery device of claim 1, further comprising a sensor for receiving feedback from the patient, the microprocessor being configured to modify the drug-delivery regimen based on the feedback. 7. The drug-delivery device of claim 1, further comprising a sensor for detecting the patient's position and activity, the microprocessor determining at least one of a frequency, time, or dosage of at least one of the first or second liquid delivered to the patient based thereon and responsively controlling delivery of the at least one of the first or second liquid. 8. The drug-delivery device of claim 1, further comprising a transceiver for receiving wireless instructions that reprogram the drug-delivery regimen. 9. The drug-delivery device of claim 1, wherein the sensor monitors physiological effects of at least one of the first or second therapeutic agent present for determining the residual amount of the at least one of the first or second therapeutic agent in the patient's tissue. 10. The drug-delivery device of claim 1, further comprising one or more valves, different from the first and second fluid-flow isolation structures, disposed in the at least one cannula, wherein the one or more valves controls fluid delivery, maintains a constant flow rate independent of variations in pressure driving a fluid flow through the cannula, and prevents backflow. 11. The drug-delivery device of claim 10, further comprising a secondary valve that is independently in fluid communication with the first and second reservoirs for separately controlling fluid delivery therefrom. 12. A drug-delivery device, comprising: a first reservoir for containing a first liquid that comprises or consists essentially of a first therapeutic agent;a second reservoir for containing a second liquid that comprises or consists essentially of a second therapeutic agent different from the first therapeutic agent;a cannula having first, second and third portions, the second and third portions branching off from the first portion to communicate fluidically with the first and second reservoirs, respectively;a first fluid-flow isolation structure located in the second portion;a second fluid-flow isolation structure located in the third portion;an electrolysis chamber including a gas-impermeable flexible membrane configured to expand and contract with increases and decreases in pressure in the electrolysis chamber, the flexible membrane also constituting a portion of at least one of the first or second reservoir;at least two electrodes in the electrolysis chamber, the electrodes being responsive to the microprocessor to produce gas in the electrolysis chamber to expand the membrane and thereby force liquid from at least one of the first or second reservoir through the cannula;memory for storing a drug-delivery regimen; anda microprocessor for controlling a delivery of the first and second liquids to a patient through the cannula based on an execution of the stored drug-delivery regimenwherein the first and second fluid-flow isolation structures prevent fluidic communication between the first and second reservoirs and isolate the first and second reservoirs from an external environment. 13. The drug-delivery device of claim 12, further comprising first and second pumps for delivering the first and second liquids to the patient, respectively, wherein the microprocessor issues instructions to actuate the first pump separately from the second pump. 14. The drug-delivery device of claim 12, further comprising a sensor for receiving feedback from the patient, the microprocessor being configured to modify the drug-delivery regimen based on the feedback. 15. The drug-delivery device of claim 12, further comprising a sensor for detecting the patient's position and activity, the microprocessor determining at least one of a frequency, time, or dosage of at least one of the first or second liquid delivered to the patient based thereon and responsively controlling delivery of the at least one of the first or second liquid. 16. The drug-delivery device of claim 12, further comprising a transceiver for receiving wireless instructions that reprogram the drug-delivery regimen. 17. The drug-delivery device of claim 12, further comprising a sensor for detecting a measured eye pressure for the patient. 18. The drug-delivery device of claim 17, wherein the sensor monitors physiological effects of at least one of the first or second therapeutic agent present for determining the residual amount of the at least one of the first or second therapeutic agent in the patient's tissue. 19. The drug-delivery device of claim 12, further comprising one or more valves, different from the first and second fluid-flow isolation structures, disposed in the at least one cannula, wherein the one or more valves controls fluid delivery, maintains a constant flow rate independent of variations in pressure driving a fluid flow through the cannula, and prevents backflow. 20. The drug-delivery device of claim 19, further comprising a secondary valve that is independently in fluid communication with the first and second reservoirs for separately controlling fluid delivery therefrom.
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