최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0356134 (2016-11-18) |
등록번호 | US-10136844 (2018-11-27) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
|
인용정보 | 피인용 횟수 : 0 인용 특허 : 328 |
Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measu
Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure additional analyte or non-analyte related signal. Such measurements may provide a background and/or sensitivity measurement(s) for use in processing sensor data and may be used to trigger events such as digital filtering of data or suspending display of data.
1. A continuous glucose sensor configured and arranged for insertion into a host for and detecting glucose in the host, the sensor comprising: a first working electrode comprising a first resistance domain, wherein the first working electrode is configured to generate a first signal having a first n
1. A continuous glucose sensor configured and arranged for insertion into a host for and detecting glucose in the host, the sensor comprising: a first working electrode comprising a first resistance domain, wherein the first working electrode is configured to generate a first signal having a first noise component related to a noise-causing species;a second working electrode comprising a second resistance domain, wherein the second working electrode is configured to generate a second signal having a second noise component related to the noise-causing species; anda third resistance domain disposed continuously over the first resistance domain and the second resistance domain,wherein each of the first resistance domain and the second resistance domain is independently formed on the first working electrode and the second working electrode, respectively. 2. The sensor of claim 1, wherein the noise-causing species comprises at least one member selected from the group consisting of externally produced H2O2, urea, lactic acid, phosphates, citrates, peroxides, amino acids, amino acid precursors, amino acid break-down products, nitric oxide, NO-donors, NO-precursors, reactive oxygen species, compounds having electroactive acidic, amine or sulfhydryl groups, acetaminophen, ascorbic acid, dopamine, ephedrine, ibuprofen, L-dopa, methyldopa, salicylate, tetracycline, tolazamide, tolbutamide, and triglycerides. 3. The sensor of claim 1, wherein the noise-causing species is non-constant. 4. The sensor of claim 1, wherein the first signal comprises a first sensitivity and the second signal comprises a second sensitivity, and wherein the third resistance domain is configured such that the first sensitivity and the second sensitivity are substantially equivalent. 5. The sensor of claim 4, wherein the first sensitivity and the second sensitivity are equivalent to ±10%. 6. The sensor of claim 1, wherein each of the first resistance domain and the second resistance domain is independently formed on the first working electrode and the second working electrode, respectively. 7. A continuous glucose sensor configured and arranged for insertion into a host for and detecting glucose in the host, the sensor comprising: a first working electrode comprising a first resistance domain, wherein the first working electrode is configured to generate a first signal having a first noise component related to a noise-causing species;a second working electrode comprising a second resistance domain, wherein the second working electrode is configured to generate a second signal having a second noise component related to the noise-causing species;a third resistance domain disposed continuously over the first resistance domain and the second resistance domain; anda physical diffusion barrier,wherein the first working electrode comprises a first electroactive surface and a first membrane portion disposed thereon, the first membrane portion comprising an active enzymatic enzyme domain and the first resistance domain, and wherein the second working electrode comprises a second electroactive surface and a second membrane portion disposed thereon, the second membrane portion comprising at least one of an inactive enzymatic portion or a non-enzymatic portion and the second resistance domain, wherein the physical diffusion barrier comprises the first resistance domain and the second resistance domain, wherein the physical diffusion barrier is configured and arranged to attenuate diffusion of the measurable species from the active enzymatic enzyme domain to the second electroactive surface by at least 2-fold. 8. The sensor of claim 7, wherein the diffusion is attenuated by at least 10-fold. 9. The sensor of claim 7, wherein the physical diffusion barrier is configured and arranged to physically block some crosstalk from the active enzymatic enzyme domain to the second electroactive surface. 10. The sensor of claim 7, wherein the physical diffusion barrier is configured and arranged to physically block an amount of a measurable species diffusing from the active enzymatic enzyme domain to the second electroactive surface, such that there is substantially no signal associated with crosstalk measured at the second working electrode. 11. The sensor of claim 7, wherein the physical diffusion barrier comprises a first barrier layer formed on the first working electrode and a second barrier layer formed on the second working electrode, wherein each of the first barrier layer and the second barrier layer is independently formed. 12. A continuous glucose sensor configured and arranged for insertion into a host for and detecting glucose in the host, the sensor comprising: a first working electrode comprising a first resistance domain, wherein the first working electrode is configured to generate a first signal having a first noise component related to a noise-causing species;a second working electrode comprising a second resistance domain, wherein the second working electrode is configured to generate a second signal having a second noise component related to the noise-causing species; anda third resistance domain disposed continuously over the first resistance domain and the second resistance domain,wherein the first working electrode comprises a first electroactive surface and a first membrane portion disposed thereon, the first membrane portion comprising an active enzymatic enzyme domain and the first resistance domain, and wherein the second working electrode comprises a second electroactive surface and a second membrane portion disposed thereon, the second membrane portion comprising at least one of an inactive enzymatic portion or a non-enzymatic portion and the second resistance domain, wherein the active enzymatic enzyme domain is configured to generate a measurable species, wherein the first electroactive surface and the second electroactive surface are spaced closer together than a crosstalk distance. 13. The sensor of claim 12, wherein the crosstalk distance comprises a distance less than a maximum distance the measurable species can diffuse, and generate a signal associated with crosstalk. 14. The sensor of claim 12, wherein the first electroactive surface and the second electroactive surface are spaced a distance that allows noise caused by a local point source that produces noise-causing species to be measured equivalently at the first and second electroactive surfaces. 15. The sensor of claim 12, wherein each of the first electroactive surface and the second electroactive surface is configured and arranged to integrate the signal caused by a plurality of local point sources that produce noise-causing species in vivo, such that the first noise component and the second noise component are substantially equivalent. 16. The sensor of claim 12, wherein the first electroactive surface and the second electroactive surface are configured and arranged to integrate signals detected about a circumference of the sensor.
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