초록 ▼

One aspect of the present disclosure relates to a system that can employ multi-modal imaging to provide an image with an enhanced resolution. In some instances, the multi-modal imaging can allow an operator to determine and control a tissue margin without the need for intra-operative tissue patholog

One aspect of the present disclosure relates to a system that can employ multi-modal imaging to provide an image with an enhanced resolution. In some instances, the multi-modal imaging can allow an operator to determine and control a tissue margin without the need for intra-operative tissue pathology. The system can include an imaging system that includes a gamma camera to detect a gamma image and an optical imaging modality to detect an optical image. The system can also include a display device to display an enhanced gamma image created based on a function of the optical image. The enhanced gamma image illustrates a characteristic of a disease in the field of view (e.g., a lymphatic pathway, a sentinel lymph node target, or a satellite disease state).

대표청구항 ▼

1. A method comprising: receiving, by a system comprising a processor, a collimator-based optical image of a field of view related to a patient, a lens-based optical image of the field of view, and a gamma image of the field of view;determining, by the system, a resolution corruption function for op

1. A method comprising: receiving, by a system comprising a processor, a collimator-based optical image of a field of view related to a patient, a lens-based optical image of the field of view, and a gamma image of the field of view;determining, by the system, a resolution corruption function for optical imaging based on the collimator-based optical image of the field of view and the lens-based optical image of the field of view;approximating, by the system, a resolution corruption function for gamma imaging based on the resolution corruption function for optical imaging;enhancing, by the system, a resolution of the gamma image of the field of view based on the resolution corruption function for gamma imaging. 2. The method of claim 1, wherein the collimator-based optical image of the field of view is a low-resolution image and the lens-based optical image of the field of view is a high-resolution image. 3. The method of claim 1, wherein the gamma image of the field of view is a low resolution image. 4. The method of claim 1, wherein the resolution corruption function for gamma imaging is approximated as equal to the resolution corruption function for optical imaging. 5. The method of claim 1, wherein the optical images are produced by an optical imaging modality and the gamma image is produced by a gamma imaging modality. 6. The method of claim 1, wherein the collimator-based optical image and the lens-based optical image of the field of view are formed by splitting an optical beam at a beam splitter to permit collimator-based detection and lens-based detection. 7. A method comprising: receiving a gamma image of a field of view of a patient;receiving a first optical image of the field of view of the patient;receiving a second optical image of the field of view of the patient;creating, by a system comprising a processor, an enhanced gamma image of the field of view based on the first optical image and the second optical image;displaying the enhanced gamma image to provide intraoperative guidance,wherein the enhanced gamma image has a greater resolution than the gamma image. 8. The method of claim 7, wherein the first optical image comprises a collimator-based optical image and the second optical image comprises a lens-based optical image. 9. The method of claim 8, wherein the resolution of the gamma image is increased based on a difference between the collimator-based optical image and the lens-based optical image. 10. The method of claim 7, wherein the enhanced gamma image illustrates a characteristic of a disease in the field of view that facilitates the intraoperative guidance. 11. A system comprising: a gamma camera configured to receive a gamma image of a field of view of a patient,an optical imaging modality configured to receive: a first optical image of the field of view of the patient, anda second optical image of the field of view of the patient;a processor that creates an enhanced gamma image of the field of view based on the first optical image and the second optical image; anda display device that displays the enhanced gamma image to provide intraoperative guidance,wherein the enhanced gamma image has a greater resolution than the gamma image. 12. The system of claim 11, wherein the first optical image comprises a collimator-based optical image and the second optical image comprises a lens-based optical image. 13. The system of claim 11, wherein the resolution of the gamma image is increased based on a difference between the collimator-based optical image and the lens-based optical image. 14. The system of claim 11, wherein the enhanced gamma image illustrates a characteristic of a disease in the field of view that facilitates the intraoperative guidance.