[특허]Vaccine compositions comprising a saponin adjuvant

Vaccine compositions comprising a saponin adjuvant 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-038/00 A61K-039/00 A61K-039/02 A61K-039/39 A61K-039/12 A61K-039/145 A61K-039/015 A61K-039/09 A61K-039/102 A61K-039/104
출원번호	US-0354233 (2016-11-17)
등록번호	US-10143745 (2018-12-04)
우선권정보	GB-0525321.6 (2005-12-13); GB-0609902.2 (2006-05-18); GB-0620336.8 (2006-10-12); GB-0620337.6 (2006-10-12)
발명자 / 주소	Vandepapeliere, Pierre
출원인 / 주소	GlacoSmithKline Biologicals, S.A.
대리인 / 주소	Campen, Virginia G.
인용정보	피인용 횟수 : 0 인용 특허 : 73

초록 ▼

The present invention provides a human dose of an immunogenic composition comprising an antigen or antigenic preparation, in combination with an adjuvant which adjuvant comprises an immunologically active saponin fraction derived from the bark of Quillaja saponaria Molina presented in the form of a liposome and a lipopolysaccharide wherein said saponin fraction and said lipopolysaccharide are both present in said human dose at a level of below 30 μg. The present invention further provides an adjuvant composition in a human dose suitable volume comprising between 1 and 30 μg of a lipopolysaccharide and between 1 and 30 μg of an immunologically active saponin fraction presented in the form of a liposome.

대표청구항 ▼

1. A method of vaccination of a human individual comprising intramuscular delivery of a human dose of an immunogenic composition comprising an antigen in combination with an adjuvant, which adjuvant comprises the QS21 saponin fraction of Quil A from the bark of Quillaja saponaria Molina presented in the form of a liposome and a lipopolysaccharide, wherein said saponin fraction and said lipopolysaccharide are each present in said human dose at a level of about 25 μg, wherein the antigen is selected from the group consisting of a Moraxella catarrhalis protein antigen and a non-typeable Haemophilus influenzae protein antigen, wherein said adjuvant further comprises a sterol, wherein the ratio of saponin:sterol is from 1:1 to 1:100 w/w. 2. The method according to claim 1, wherein the ratio of saponin:sterol is from 1:1 to 1:5 w/w. 3. The method according to claim 1, wherein said sterol is cholesterol. 4. The method according to claim 1, wherein the lipopolysaccharide is 3D-MPL and the ratio of QS21:3D-MPL is 1:1 w/w. 5. The method of claim 1, wherein the antigen is Moraxella catarrhalis protein antigen UspA2. 6. The method of claim 1, wherein the antigen is non-typeable Haemophilus influenzae antigen Protein D. 7. A method of vaccination of a human individual comprising intramuscular delivery of a human dose of an immunogenic composition comprising an antigen selected from the group consisting of a Moraxella catarrhalis protein antigen and a non-typeable Haemophilus influenzae protein antigen, in combination with an adjuvant, which adjuvant comprises the QS21 saponin fraction of Quil A from the bark of Quillaja saponaria Molina presented in the form of a liposome and a lipopolysaccharide, wherein said saponin fraction and said lipopolysaccharide are each present in said human dose at a level of below 30 μg. 8. The method according to claim 7, wherein said adjuvant further comprises a sterol, wherein the ratio of saponin:sterol is from 1:1 to 1:100 w/w. 9. The method according to claim 8, wherein the ratio of saponin:sterol is from 1:1 to 1:5 w/w. 10. The method according to claim 8, wherein said sterol is cholesterol. 11. The method according to claim 7, wherein the lipopolysaccharide is 3D-MPL and the ratio of QS21:3D-MPL is 1:1 w/w. 12. The method of claim 7, wherein the antigen is Moraxella catarrhalis protein antigen UspA2. 13. The method of claim 7, wherein the antigen is non-typeable Haemophilus influenzae antigen Protein D.

이 특허에 인용된 특허 (73)

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
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연합인증

Vaccine compositions comprising a saponin adjuvant 원문보기

초록 ▼

대표청구항 ▼

연구과제 타임라인

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Vaccine compositions comprising a saponin adjuvant 원문보기

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대표청구항 ▼

연구과제 타임라인

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