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Provided herein are systems, methods and devices for performing one or more titrations for oral appliance therapy. For example, a method for evaluating an outcome of oral appliance therapy in a subject is discussed herein. The method can include positioning an adjustable mandibular displacement devi

Provided herein are systems, methods and devices for performing one or more titrations for oral appliance therapy. For example, a method for evaluating an outcome of oral appliance therapy in a subject is discussed herein. The method can include positioning an adjustable mandibular displacement device in an oral cavity of a subject and implementing an automatic titration protocol. The protocol can include controlling a protrusion level of the adjustable mandibular displacement device during a test period, monitoring physiological information from the subject during the test period, and analyzing the physiological information to evaluate the outcome of oral appliance therapy.

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1. A system for performing a titration for oral appliance therapy, comprising: an adjustable mandibular displacement device configured to be positioned in an oral cavity of a subject;a monitoring unit configured to sense physiological information from the subject during a test period; anda control u

1. A system for performing a titration for oral appliance therapy, comprising: an adjustable mandibular displacement device configured to be positioned in an oral cavity of a subject;a monitoring unit configured to sense physiological information from the subject during a test period; anda control unit comprising a processing unit and a memory operatively coupled to the processing unit, the memory having computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to:receive one or more physiological inputs from the monitoring unit during the test period;detect one or more respiratory events during the test period using the one or more psychological inputs;adjust a protrusion level of the adjustable mandibular displacement device during the test period based on at least one of frequency or severity of the one or more respiratory events, at least one of a magnitude or rate of adjustment being related to at least one of the frequency or the severity of the one or more respiratory events; andevaluate an outcome of oral appliance therapy with a mandibular repositioning appliance based on a history of movement of the adjustable mandibular displacement device and the physiological information during the test period. 2. The system of claim 1, wherein the evaluation comprises predicting whether the subject is a favorable candidate for oral appliance therapy or predicting an effective protrusion level of the adjustable mandibular displacement device. 3. The system of claim 2, wherein evaluating an outcome of oral appliance therapy further comprises determining whether a frequency of respiratory events at or above a given protrusion level during the test period is less than a predefined value or determining whether a percentage of time at or below a given protrusion level is greater than or equal to a predefined percentage of the test period. 4. The system of claim 3, wherein the memory has further computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to calculate a frequency of respiratory events at a plurality of protrusion levels by: determining a number of respiratory events at or above each of the plurality of protrusion levels; anddividing each of the number of respiratory events by an amount of time at or above each of the plurality of protrusion levels, wherein titrating further comprises identifying one or more of the plurality of protrusion levels where the frequency of respiratory events is less than the predefined value. 5. The system of claim 4, wherein evaluating an outcome of oral appliance therapy further comprises determining whether a percentage of time at or below each of the one or more protrusion levels is greater than or equal to a predefined percentage of the test period. 6. The system of claim 5, wherein the memory has further computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to determine that an effective protrusion level for oral appliance therapy is a smallest protrusion level where the frequency of respiratory events at the one or more of the plurality of protrusion levels during the test period is less than the predefined value and the percentage of time at or below the one or more of the plurality of protrusion levels is greater than or equal to the predefined percentage of the test period. 7. The system of claim 3, wherein the memory has further computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to determine that an effective protrusion level for oral appliance therapy is a smallest protrusion level where the frequency of respiratory events at or above the given protrusion level during the test period is less than the predefined value and the percentage of time at or below the given protrusion level is greater than or equal to the predefined percentage of the test period. 8. The system of claim 4, wherein the frequency of respiratory events is calculated at a plurality of protrusion levels where an amount of time at or above each of the plurality of protrusion levels is at least 5 minutes. 9. The system of claim 2, wherein titrating further comprises optimizing the effective protrusion level of the adjustable mandibular displacement device using the one or more physiological inputs from the subject. 10. The system of claim 9, wherein the monitoring unit further comprises a force sensor, and the one or more physiological inputs comprise a force applied on the subject's teeth by the adjustable mandibular displacement device. 11. The system of claim 1, wherein the memory has further computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to monitor changes in a protrusion level of the adjustable mandibular displacement device during the test period, wherein the changes in the protrusion level of the adjustable mandibular displacement device define the history of movement of the adjustable mandibular displacement device. 12. The system of claim 11, wherein the history of movement of the adjustable mandibular displacement device comprises movement between at least two protrusion levels. 13. The system of claim 12, wherein the history of movement includes an amount of time the adjustable mandibular displacement device spends at each of the at least two protrusion levels. 14. The system of claim 13, wherein the memory has further computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to analyze the history of movement to determine a percentage of time the adjustable mandibular displacement device spends at or below each of the at least two protrusion levels. 15. The system of claim 14, wherein the evaluation is based on a frequency of respiratory events at or above each of the at least two protrusion levels and the percentage of time the adjustable mandibular displacement device spends at or below each of the at least two protrusion levels. 16. The system of claim 15, wherein the memory has further computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to generate a graphical representation of at least one of the frequency of respiratory events at or above each of the at least two protrusion levels and the percentage of time the adjustable mandibular displacement device spends at or below each of the at least two protrusion levels, wherein the evaluation is based on the graphical representation. 17. The system of claim 1, wherein the memory has further computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to: classify a magnitude of severity of at least one of the one or more respiratory events, and wherein adjusting a protrusion level of the adjustable mandibular displacement device during the test period comprises determining at least one of a magnitude and rate of adjustment of the protrusion level based on the magnitude of severity of the respiratory event. 18. The system of claim 17, wherein the monitoring unit further comprises an airflow monitor and an oxygen saturation monitor, and the one or more physiological inputs from the subject comprise oxygen saturation and respiratory airflow, and wherein classifying a severity level of a respiratory event comprises: classifying a severity level of a decrease in oxygen saturation associated with the respiratory event into one of n categories;classifying a severity level of a decrease in respiratory airflow associated with the respiratory event into one of m categories; anddetermining the magnitude of severity of the respiratory event using an nxm matrix based on the severity levels of the decrease in oxygen saturation and the decrease in respiratory airflow associated with the respiratory event, where n and m are integers>1, and wherein adjusting a protrusion level of the adjustable mandibular displacement device during the test period comprises determining at least one of a magnitude and rate of adjustment of the protrusion level based on the magnitude of the severity determined using the n×m matrix. 19. The system of claim 18, wherein m is 3, and a first category corresponds to an approximately 80-100% decrease in respiratory airflow, a second category corresponds to an approximately 45-79% decrease in respiratory airflow, and a third category corresponds to an approximately 30-44% decrease in respiratory airflow. 20. The system of claim 18, wherein n is 3, and a first category corresponds to at least an approximately 6% decrease in oxygen saturation from real-time or baseline oxygen saturation, a second category corresponds to between an approximately 3% and 6% decrease in oxygen saturation from real-time or baseline oxygen saturation and a third category corresponds to a less than an approximately 3% decrease in oxygen saturation from real-time or baseline oxygen saturation. 21. The system of claim 18, wherein the memory has further computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to: calculate a frequency of the respiratory event; andmultiply the frequency of the respiratory event by the magnitude of severity of the respiratory event using an nxm matrix to obtain a frequency-severity index, wherein adjusting a protrusion level of the adjustable mandibular displacement device during the test period comprises determining at least one of the magnitude and rate of adjustment of the protrusion level based on the frequency-severity index. 22. The system of claim 17, wherein the memory has further computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to classify a frequency level of the respiratory event into one of q categories and obtain a frequency-severity index using an nxmxq matrix based on the severity and frequency levels associated with the respiratory event, where n and m and q are integers>1, and wherein adjusting a protrusion level of the adjustable mandibular displacement device during the test period comprises determining at least one of a magnitude and rate of adjustment of the protrusion level based on the frequency-severity index. 23. The system of claim 1, wherein detecting one or more respiratory events comprises detecting a decrease in oxygen saturation within a period of time after detecting a decrease in respiratory airflow. 24. The system of claim 23, wherein the period of time is subject-specific and determined based on an analysis of the detected respiratory events. 25. The system of claim 24, wherein the analysis is performed before or during the test period. 26. The system of claim 23, wherein the period of time is fixed and approximately 10-40 seconds. 27. The system of claim 1, wherein the monitoring unit comprises an air flow monitor, and the physiological information from the subject during the test period further comprises respiratory airflow. 28. The system of claim 1, wherein adjusting a protrusion level of the adjustable mandibular displacement device during the test period is performed automatically. 29. The system of claim 1, wherein monitoring unit further comprises an airflow monitor and an oxygen saturation monitor, and the one or more physiological inputs from the subject comprise oxygen saturation and respiratory airflow, or wherein the monitoring unit further comprises an airflow monitor and a sound monitor or a vibration monitor, and the one or more physiological inputs from the subject comprise respiratory airflow and acoustic energy or vibration generated by the subject, or wherein the monitoring unit further comprises a polysomnograph, and the one or more physiological inputs further comprise at least one of sleep stage, sleep position and force applied on the subject's teeth by the adjustable mandibular displacement device. 30. The system of claim 1, wherein the test period is while the subject is sleeping. 31. The system of claim 1, wherein the test period is a single sleep session or the test period includes multiple sleep sessions. 32. The system of claim 1, wherein adjusting a protrusion level of the adjustable mandibular displacement device during the test period comprises at least one of increasing protrusion level or decreasing protrusion level of the adjustable mandibular displacement device. 33. The system of claim 1, wherein a greater magnitude or rate of adjustment of the protrusion level of the adjustable mandibular displacement device corresponds to a more frequent or severe respiratory event, and a lesser magnitude or rate of adjustment of the protrusion level of the adjustable mandibular displacement device corresponds to a less frequent or severe respiratory event. 34. The system of claim 1, wherein the test period has a duration less than one night. 35. The system of claim 1, wherein the memory has further computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to: classify a frequency level of at least one of the one or more respiratory events, and wherein adjusting a protrusion level of the adjustable mandibular displacement device during the test period comprises determining at least one of a magnitude and rate of adjustment of the protrusion level based on the frequency level of the respiratory event. 36. The system of claim 1, wherein adjusting a protrusion level of the adjustable mandibular displacement device during the test period comprises at least one of: in response to not detecting a respiratory event during a fixed period of time during the test period, adjusting protrusion level to induce a change in respiratory airflow, orin response to a frequency of respiratory events falling below a predetermined threshold, adjusting protrusion level of the adjustable mandibular displacement device to optimize respiratory airflow. 37. The system of claim 1, wherein the one or more respiratory events are at least one of an apnea, a hypopnea, a flow limited breath or a snoring event. 38. A system for performing a titration for oral appliance therapy based on data collected at a plurality of protrusion levels, comprising: an adjustable mandibular displacement device configured to be positioned in an oral cavity of a subject; anda control unit comprising a processing unit and a memory operatively coupled to the processing unit, the memory having computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to:receive physiological data collected from a subject during a test period;detect one or more respiratory events using the physiological data;receive data related to a protrusion level of the adjustable mandibular displacement device during the test period;adjust the protrusion level of the adjustable mandibular displacement device during the test period based on at least one of frequency or severity of the one or more respiratory events, at least one of a magnitude or rate of adjustment being related to at least one of the frequency or the severity of the one or more respiratory events; andevaluate an outcome of oral appliance therapy with a mandibular repositioning appliance based on the physiological data collected from the subject at the plurality of protrusion levels of the adjustable mandibular displacement device during the test period. 39. The system of claim 38, wherein evaluating an outcome of oral appliance therapy further comprises comparing a frequency of occurrence of the one or more respiratory events at different protrusion levels. 40. The system of claim 39, wherein the memory has further computer-executable instructions stored thereon that, when executed by the processing unit, cause the system to determine that the subject is a candidate for oral appliance therapy if the frequency occurrence of the one or more respiratory events decreases between successively greater protrusion levels. 41. The system of claim 38, wherein the data related to the protrusion level of the adjustable mandibular displacement device comprises an amount of time the adjustable mandibular displacement device spends at each of the plurality of protrusion levels. 42. The system of claim 38, wherein the evaluation comprises predicting an effective protrusion level of the adjustable mandibular displacement device. 43. A method for performing a titration for oral appliance therapy, comprising: positioning an adjustable mandibular displacement device in an oral cavity of a subject during a test period;monitoring physiological information from the subject during the test period;detecting one or more respiratory events during the test period using the physiological information;adjusting a protrusion level of the adjustable mandibular displacement device during the test period based on at least one of frequency or severity of the one or more respiratory events, at least one of a magnitude or rate of adjustment being related to at least one of the frequency or the severity of the one or more respiratory events; andevaluating the outcome of oral appliance therapy with a mandibular repositioning appliance based on a history of movement of the adjustable mandibular displacement device and the physiological information during the test period. 44. A method for performing a titration for oral appliance therapy based on data collected at a plurality of protrusion levels of an adjustable mandibular displacement device, comprising: receiving physiological data collected from a subject during a test period;detecting one or more respiratory events during the test period using the physiological data;receiving data related to a protrusion level of the adjustable mandibular displacement device during the test period;adjusting the protrusion level of the adjustable mandibular displacement device during the test period based on at least one of frequency or severity of the one or more respiratory events, at least one of a magnitude or rate of adjustment being related to at least one of the frequency or the severity of the one or more respiratory events; andevaluating an outcome of oral appliance therapy with a mandibular repositioning appliance based on the physiological data collected from the subject at the plurality of protrusion levels of the adjustable mandibular displacement device during the test period.