[미국특허]
Treatment of erectile dysfunction and other indications
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-009/00
A61K-009/06
A61K-031/53
A61K-047/02
A61K-047/06
A61K-047/10
A61K-047/12
A61K-047/14
A61K-047/16
A61K-047/18
A61K-047/22
A61K-047/26
A61K-047/36
A61K-009/107
A61K-031/198
A61K-031/495
A61K-031/506
A61K-031/519
A61K-031/4985
출원번호
US-0652336
(2017-07-18)
등록번호
US-10172865
(2019-01-08)
발명자
/ 주소
Fossel, Eric T.
출원인 / 주소
Strategic Science & Technologies, LLC
대리인 / 주소
Wolf, Greenfield & Sacks, P.C.
인용정보
피인용 횟수 :
0인용 특허 :
120
초록▼
The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a phosphodiesterase type 5
The present invention generally relates to the transdermal delivery of various compounds. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment. One set of embodiments provides a composition for topical delivery comprising a phosphodiesterase type 5 inhibitor and/or a salt thereof, and optionally, a hostile biophysical environment and/or a nitric oxide donor. In some cases, the composition may be stabilized using a combination of a stabilization polymer (such as xanthan gum, KELTROL® BT and/or KELTROL® RD), propylene glycol, and a polysorbate surfactant such as Polysorbate 20, which combination unexpectedly provides temperature stability to the composition, e.g., at elevated temperatures such as at least 40° C. (at least about 104° F.), as compared to compositions lacking one or more of these.
대표청구항▼
1. A method of treating sexual dysfunction in a female, the method comprising: applying, to the genital region of a female, a composition comprising:a nitric oxide donor comprising L-arginine and/or L-arginine hydrochloride at a concentration of about 2.5% to about 15% by weight,xanthan gum at no mo
1. A method of treating sexual dysfunction in a female, the method comprising: applying, to the genital region of a female, a composition comprising:a nitric oxide donor comprising L-arginine and/or L-arginine hydrochloride at a concentration of about 2.5% to about 15% by weight,xanthan gum at no more than about 1 wt %;propylene glycol at least about 6% by weight;Polysorbate 20 at no more than about 3 wt %; andsildenafil and/or a salt thereof,wherein the composition has an ionic strength of at least about 1 M, and wherein the composition is a cream, gel, or lotion. 2. The method of claim 1, wherein the composition is stable when exposed to a temperature of 40° C. for at least about 4 weeks. 3. The method of claim 1, wherein the ionic salt is present at a concentration of at least about 5% by weight of the composition. 4. The method of claim 1, wherein the ionic salt comprises one or more salts selected from the group consisting of sodium chloride, choline chloride, magnesium chloride, and calcium chloride. 5. The method of claim 1, wherein the composition further comprises a package containing the nitric oxide donor, the package being selected from the group consisting of liposomes, emulsions of collagen, collagen peptides, and combinations thereof. 6. The method of claim 1, wherein the xanthan gum is present at a concentration of at least about 0.5% by weight of the composition. 7. The method of claim 1, wherein the polysorbate surfactant is present at a concentration of at least about 1% by weight of the composition. 8. The method of claim 1, wherein the composition further comprises one or more of glyceryl stearate, cetyl alcohol, squalene, isopropyl myristate, or oleic acid. 9. The method of claim 1, wherein the composition comprises sildenafil. 10. A method of treating sexual dysfunction in a female, the method comprising: applying, to the genital region of a female, a composition comprising:a nitric oxide donor comprising L-arginine and/or L-arginine hydrochloride at a concentration of about 2.5% to about 15% by weight,xanthan gum at no more than about 1 wt %;propylene glycol at least about 6% by weight;a polysorbate at no more than about 3 wt %; andsildenafil and/or a salt thereof,wherein the composition has an ionic strength of at least about 1 M, and wherein the composition is a cream, gel, or lotion. 11. The method of claim 10, wherein the composition is stable when exposed to a temperature of 40° C. for at least about 4 weeks. 12. The method of claim 10, wherein the ionic salt is present at a concentration of at least about 5% by weight of the composition. 13. The method of claim 10, wherein the ionic salt comprises one or more salts selected from the group consisting of sodium chloride, choline chloride, magnesium chloride, and calcium chloride. 14. The method of claim 10, wherein the composition further comprises a package containing the nitric oxide donor, the package being selected from the group consisting of liposomes, emulsions of collagen, collagen peptides, and combinations thereof. 15. The method of claim 10, wherein the xanthan gum is present at a concentration of at least about 0.5% by weight of the composition. 16. The method of claim 10, wherein the polysorbate surfactant is present at a concentration of at least about 1% by weight of the composition. 17. The method of claim 10, wherein the composition further comprises one or more of glyceryl stearate, cetyl alcohol, squalene, isopropyl myristate, or oleic acid. 18. The method of claim 10, wherein the composition comprises sildenafil.
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