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Methods and compositions for nuclease-mediated targeted integration of transgenes 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-015/82
  • C12N-015/87
  • C12N-015/85
  • C12N-015/10
출원번호 US-0889162 (2013-05-07)
등록번호 US-10174331 (2019-01-08)
발명자 / 주소
  • Cost, Gregory J.
  • Urnov, Fyodor
  • Ainley, W. Michael
  • Petolino, Joseph F.
  • Samuel, Jayakumar Pon
  • Webb, Steven R.
  • Sastry-Dent, Lakshmi
출원인 / 주소
  • Sangamo Therapeutics, Inc.
대리인 / 주소
    Pasternak Patent Law
인용정보 피인용 횟수 : 0  인용 특허 : 55

초록

Disclosed herein are methods and compositions for homology-independent targeted insertion of donor molecules into the genome of a cell.

대표청구항 ▼

1. A method of integrating a transgene into an endogenous locus of a cell, the method comprising; introducing one or more nucleases into the cell, the cell comprising a circular double-stranded plasmid donor, the double-stranded plasmid donor comprising: a transgene; and first and second sequences f

이 특허에 인용된 특허 (55)

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