Antioxidant dietary supplement and related method
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-036/60
A61K-036/82
A61K-036/906
A61K-036/53
A61K-036/9066
A61K-036/31
A23L-002/52
A61K-031/352
A61K-045/06
A23L-033/105
A23L-033/16
A23L-033/15
A23L-033/155
출원번호
US-0342627
(2016-11-03)
등록번호
US-10201583
(2019-02-12)
발명자
/ 주소
Fast, David J.
Patterson, Jennifer
Rajgopal, Arun
Pusateri, Donald J.
Gellenbeck, Kevin W.
Scholten, Jeffrey
Missler, Stephen R.
Randolph, Russell K.
Chuang, Jennifer
Lin, Yumei
Kazlova, Valiantsina
출원인 / 주소
Access Business Group International LLC
대리인 / 주소
Warner Norcross & Judd LLP
인용정보
피인용 횟수 :
0인용 특허 :
29
초록▼
A supplement including a blend of turmeric, quercetin and rosemary, or holy basil, wasabi, and broccoli seed extract which are present in a balanced and predetermined ratio, and which stimulate the Antioxidant Response Element (ARE), Quinone Reductase, and/or induce related gene expression, for exam
A supplement including a blend of turmeric, quercetin and rosemary, or holy basil, wasabi, and broccoli seed extract which are present in a balanced and predetermined ratio, and which stimulate the Antioxidant Response Element (ARE), Quinone Reductase, and/or induce related gene expression, for example, heme oxygenase-1 (HMOX-1) expression. The blend of ingredients can be formed as or in a dietary supplement adapted for administration to a subject. The dietary supplement can be formulated so that the turmeric, quercetin and rosemary are present in a predetermined ratio of 1:3:5, or holy basil, wasabi, and broccoli seed extract in a predetermined ratio of 1:1:0.2. Additional ingredients can be included in the supplement. The supplement can synergistically affect natural antioxidant response pathways within cells of a subject to whom the supplement is administered. A related method of use is also provided.
대표청구항▼
1. A dietary supplement for stimulating an antioxidant response element (ARE) and/or inducing Heme Oxygenase-1 (HMOX-1) expression in a human, the dietary supplement comprising: turmeric;quercetin; androsemary;wherein the turmeric, quercetin, and rosemary are present in the supplement in a ratio of
1. A dietary supplement for stimulating an antioxidant response element (ARE) and/or inducing Heme Oxygenase-1 (HMOX-1) expression in a human, the dietary supplement comprising: turmeric;quercetin; androsemary;wherein the turmeric, quercetin, and rosemary are present in the supplement in a ratio of 1:3:5, respectively; andwherein the turmeric, quercetin, and rosemary cooperate to at least one of stimulate ARE and induce HMOX-1 expression when the supplement is administered to a subject. 2. The dietary supplement of claim 1, wherein the turmeric, quercetin, and rosemary are present in the supplement in an amount of 33 mg, 100 mg, and 167 mg, respectively. 3. The dietary supplement of claim 1, wherein the turmeric, quercetin, and rosemary are present in the supplement in an amount of 66 mg, 200 mg, and 333 mg, respectively. 4. The dietary supplement of claim 1, further comprising at least one of vitamins and minerals. 5. A dietary supplement for stimulating an antioxidant response element (ARE) and/or inducing Heme Oxygenase-1 (HMOX-1) expression in a human, the dietary supplement comprising: turmeric;quercetin; androsemary;wherein; the turmeric is present in an amount of from 1 to 20 weight percent,the quercetin is present in an amount of from 3 to 40 weight percent, andthe rosemary is present in an amount of from 4 to 60 weight percent,each based on the combined amount of turmeric, quercetin, and rosemary present in the supplement;wherein the turmeric is present in an amount less than the respective amounts of quercetin and rosemary; andwherein the turmeric, quercetin, and rosemary cooperate to at least one of stimulate ARE and induce HMOX-1 expression when the supplement is administered to a subject. 6. The dietary supplement of claim 5, further comprising at least one of vitamins and minerals. 7. The dietary supplement of claim 5, wherein the turmeric, quercetin, and rosemary are present in the supplement in a ratio of 1:3:5, respectively. 8. The dietary supplement of claim 5, wherein the turmeric, quercetin, and rosemary stimulate ARE in human hepatocytes stably transfected with a vector containing an ARE DNA sequence 5′-GTGACTCAGCA-3′ (SEQ ID NO:1) at a response being between about 2 and 4 times greater than another response of any one of the turmeric, quercetin, and rosemary individually. 9. The dietary supplement of claim 5, wherein the turmeric, quercetin, and rosemary decrease one of a urinary level of 8-isoprostane and a blood serum level of catalase in a human. 10. The dietary supplement of claim 5, wherein the turmeric, quercetin, and rosemary increase production of one of glutathione peroxidase and Superoxide dismutase in a human. 11. The dietary supplement of claim 5, wherein the supplement is in the form of a capsule, a tablet, a powder, a gel, or a liquid. 12. The dietary supplement of claim 5, wherein: i) the turmeric is at least one of derived and extracted from at least one of Curcuma longa; and/orii) the quercetin is at least one of derived and extracted from at least one of apples, onions, parsley, sage, tea, blueberries, blackberries, bilberries, Fava d'anta, and Sophora japonica; and/oriii) the rosemary is at least one of derived and extracted from at least one of Rosmarinus officinalis. 13. The dietary supplement of claim 5, further comprising at least one of flavors, excipients, binders, protein, complex carbohydrates, preservatives, and chelating agents. 14. The dietary supplement of claim 5, wherein: the turmeric is present in an amount of from 10 mg to 170 mg;the quercetin is present in an amount of from 20 mg to 470 mg; andthe rosemary is present in an amount of from 45 mg to 770 mg. 15. The dietary supplement of claim 1, further comprising at least one of flavors, excipients, binders, protein, complex carbohydrates, preservatives, and chelating agents.
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