IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0645810
(2017-07-10)
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등록번호 |
US-10238577
(2019-03-26)
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발명자
/ 주소 |
- Gjertsen, Jeff
- Sullivan, Timothy
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출원인 / 주소 |
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
4 |
초록
▼
Devices for delivery of fluid compositions include a delivery device including an internally pierced blister in which the device includes a plunger configured to crush the blister and deliver the contents in a lateral direction with respect to the motion of a dispensing button. Certain devices are c
Devices for delivery of fluid compositions include a delivery device including an internally pierced blister in which the device includes a plunger configured to crush the blister and deliver the contents in a lateral direction with respect to the motion of a dispensing button. Certain devices are configured for oral delivery.
대표청구항
▼
1. A device for delivery of a fluid composition, said device comprising: a housing comprising a front face, a first side, a second side and a rear face; and a top, forming an interior volume;a button comprising a first side, a second side, a first end contained within the housing and a second end ex
1. A device for delivery of a fluid composition, said device comprising: a housing comprising a front face, a first side, a second side and a rear face; and a top, forming an interior volume;a button comprising a first side, a second side, a first end contained within the housing and a second end extending out of the housing at an end opposite the top;wherein the button comprises recess adapted to mechanically interact with said button, a first tab, and a second tab;a delivery mechanism disposed in the interior volume of the housing; anda nozzle port disposed in the front face of the housing and providing a liquid communication channel into the interior volume; wherein the delivery mechanism comprises:a plunger comprising a lower section adapted to be in mechanical connection to the button, wherein the lower section comprises a first arcuate surface;an upper section comprising a cavity disposed adjacent the nozzle port and adapted to contain a crushable dosage form; anda ram member adjacent the cavity and comprising a second arcuate face; wherein said first tab and said second tab are adapted to interact with said first arcuate surface and said second arcuate surface to direct the motion of the ram in a direction other than the direction of motion of the button when activated. 2. The device of claim 1, further comprising one or more finger rests disposed on said first and/or second side of the housing. 3. The device of claim 2, wherein said one or more finger rests comprise a flange, one or more arcuate members comprising open or closed loops, one or more indentations, or one or more sets of ridges. 4. The device of claim 1, further comprising a positioning device adapted to rest against the lower teeth of a user to direct a spray from the nozzle port into the oral cavity of the user. 5. The device of claim 1, wherein the direction of motion of the ram is substantially lateral to the direction of motion of the button when activated. 6. The device of claim 1, further comprising a crushable dosage form containing a fluid composition and an internal piercing device, wherein the internal piercing device comprises a nozzle disposed adjacent or within the nozzle port. 7. The device of claim 6, in which the fluid is a liquid, powder or a reconstituted powder. 8. The device of claim 6, wherein the fluid is a medical composition. 9. The device of claim 8, in which the fluid is a cardiovascular drug, steroid, barbiturate, benzodiazepine, analgesic, anesthetic, sedative, anti-inflammatory, non-steroidal anti-inflammatory (NSAID), antigen; vaccine, hormone, endorphin, enkephalin, dynorphin endomorphin, cannabinoid, biosimilar, synthetic or semi-synthetic opioid or alkaloid analgesic or combinations of any thereof. 10. The device of claim 8 in which the fluid comprises fentanyl, ketamine, a ketamine analog, esketamine, buprenorphine, naloxone, acetaminaphine, morphine, ethylmorphine, oxycodone, hydrocodone, meperidine, hydromorphone, alfentanil, remifentanil, sufentanil etorphine, opiod peptide, or a pharmaceutically acceptable, salt, derivative, prodrug, enantiomer, racemate, or isomer of any thereof. 11. The device of claim 8, in which the fluid comprises a calcium channel blocker, a mineral, an NMDA antagonist, dextromethorphan, memantine, a cholecystokinin antagonist, proglumide, or a phosphodiesterase inhibitor. 12. A method of delivering a fluid substance to the sublingual or buccal tissue of a human or non-human animal comprising dispensing a fluid substance from the device of claim 1. 13. A device for delivery of a fluid composition, said device comprising: a housing comprising a front face, a first side, a second side and a rear face, and a top, forming an interior volume;a button comprising a first side, a second side, a first end contained within the housing and a second end extending out of the housing at an end opposite the top;wherein the button comprises recess adapted to mechanically interact with said button, a first tab, and a second tab;a delivery mechanism disposed in the interior volume of the housing; anda nozzle port disposed in the front face of the housing and providing a liquid communication channel into the interior volume;wherein the delivery mechanism comprises:a plunger comprising a lower section adapted to be in mechanical connection to the button, wherein the lower section comprises a first arcuate surface;an upper section comprising a cavity disposed adjacent the nozzle port and adapted to contain a crushable dosage form; anda ram member adjacent the cavity and comprising a second arcuate face;wherein said first tab and said second tab are adapted to interact with said first arcuate surface and said second arcuate surface respectively, effective to direct the motion of the ram in a direction other than the direction of motion of the button when activated; anda crushable dosage form contained in the cavity and containing a fluid composition and an internal piercing device,wherein the internal piercing device comprises a nozzle disposed adjacent or within the nozzle port when activated. 14. The device of claim 13, further comprising one or more finger rests disposed on said first and/or second side of the housing. 15. The device of claim 14, wherein said one or more finger rests comprise a flange, one or more arcuate members comprising open or closed loops, one or more indentations, or one or more sets of ridges. 16. The device of claim 13, further comprising a positioning device adapted to rest against the lower teeth of a user to direct a spray from the nozzle port into the oral cavity of the user. 17. The device of claim 13, wherein the direction of motion of the ram is substantially lateral to the direction of motion of the button when activated. 18. The device of claim 13, in which the fluid is a liquid, powder or a reconstituted powder. 19. The device of claim 18, wherein the fluid is a medical composition. 20. The device of claim 18, in which the fluid is a cardiovascular drug, steroid, barbiturate, benzodiazepine, analgesic, anesthetic, sedative, anti-inflammatory, non-steroidal anti-inflammatory (NSAID), antigen, vaccine, hormone, endorphin, enkephalin, dynorphin endomorphin, cannabinoid, biosimilar, synthetic or semi-synthetic opioid or alkaloid analgesic or combinations of any thereof. 21. The device of claim 18 in which the fluid comprises fentanyl, ketamine, a ketamine analog, esketamine, buprenorphine, naloxone, acetaminaphine, morphine, ethylmorphine, oxycodone, hydrocodone, meperidine, hydromorphone, alfentanil, remifentanil, sufentanil etorphine, opiod peptide, or a pharmaceutically acceptable, salt, derivative, prodrug, enantiomer, racemate, or isomer of any thereof. 22. The device of claim 18, in which the fluid comprises a calcium channel blocker, a mineral, an NMDA antagonist, dextromethorphan, memantine, a cholecystokinin antagonist, proglumide, or a phosphodiesterase inhibitor. 23. A method of administering a drug to the oral cavity of a user comprising: positioning a device according to claim 13 such that the nozzle port is aimed into the oral cavity of the user; andactivating the button effected to crush the dosage form and administer the fluid in a spray, stream or mist into the oral cavity of the user;wherein the device is positioned such that a user activates the button in an upward direction and the fluid is dispensed laterally into the oral cavity. 24. The method of claim 23, wherein the device comprises a positioning device, and wherein the positioning device is rested against the lower teeth of the user during activation of the button.
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