최소 단어 이상 선택하여야 합니다.
최대 10 단어까지만 선택 가능합니다.
다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
DataON 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Edison 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0570673 (2014-12-15) |
등록번호 | US-10238604 (2019-03-26) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 0 인용 특허 : 477 |
Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a tar
Controlled activation identifiers for use in ingestible compositions, such as pharma-informatics enabled compositions, are provided. The identifiers include a controlled activation element that provides for activation of the identifier in response to the presence of a predetermined stimulus at a target site of interest. The invention finds use in a variety of different applications, including but not limited to, monitoring of therapeutic regimen compliance, tracking the history of pharmaceutical agents, etc.
1. A pharmaceutical composition comprising: a pharmaceutically active agent;a controlled activation identifier configured to transmit a signal upon contact with a target site of a body, wherein the controlled activation identifier comprises: first and second materials with dissimilar electrochemical
1. A pharmaceutical composition comprising: a pharmaceutically active agent;a controlled activation identifier configured to transmit a signal upon contact with a target site of a body, wherein the controlled activation identifier comprises: first and second materials with dissimilar electrochemical properties;a dried conductive medium precursor; anda plurality of protective layers comprising: a first layer configured to prevent mechanical damage to the controlled activation identifier;a second layer configured to dissolve at a target pH; anda third layer configured to control exposure of the dried conductive medium precursor to the target site. 2. The pharmaceutical composition according to claim 1, wherein the controlled activation identifier is configured to transmit the signal upon contact with a target site fluid present at the target site. 3. The pharmaceutical composition according to claim 2, wherein the signal is consistent regardless of variations in properties of the target site fluid. 4. The pharmaceutical composition according to claim 3, wherein the first and second materials are configured to create a voltaic cell when in contact with an electrically conductive fluid at the target site, wherein the voltaic cell supplies power to the controlled activation identifier. 5. The pharmaceutical composition according to claim 1, wherein the dried conductive medium precursor is configured to produce a conductive medium that conductively couples the first and second materials upon the dried conductive medium precursor being wetted, and wherein the controlled activation identifier transmits the signal when the dried conductive medium couples the first and second materials. 6. The pharmaceutical composition according to claim 1, wherein the third layer comprises a semipermeable membrane. 7. The pharmaceutical composition according to claim 1, wherein the third layer comprises a solid barrier comprising a fluid flow path. 8. The pharmaceutical composition according to claim 7, wherein the flow path is a capillary fluid flow path. 9. The pharmaceutical composition according to claim 8, wherein the capillary fluid flow path comprises at least one surface, the at least one surface comprising a surface treatment configured to enhance hydrophilic fluid flow through the capillary flow path. 10. The pharmaceutical composition according to claim 1, wherein the controlled activation identifier comprises a polymeric coating configured to dissolve upon contact with a fluid in a time delayed manner. 11. The pharmaceutical composition according to claim 10, wherein the polymeric coating is configured to dissolve over a time period, the time period corresponding to a time required for a target site fluid pH or conductivity to reach a target value following ingestion of an external fluid. 12. The pharmaceutical composition according to claim 1, wherein the controlled activation identifier comprises an integrated circuit. 13. The pharmaceutical composition according to claim 12, wherein the controlled activation identifier comprises at least one transmitter. 14. The pharmaceutical composition according to claim 13, wherein the transmitter comprises an electrode. 15. The pharmaceutical composition according to claim 1, wherein the composition is an oral formulation. 16. The pharmaceutical composition according to claim 15, wherein the oral formulation is a solid oral formulation. 17. The pharmaceutical composition according to claim 16, wherein the solid formulation is a pill.
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