Process for the reductive amination and selective hydrogenation of substrates containing a selected halogen
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07C-209/26
C07C-209/36
C07C-249/04
출원번호
US-0678183
(2017-08-16)
등록번호
US-10252979
(2019-04-09)
우선권정보
EP-13183017 (2013-09-04)
발명자
/ 주소
Moonen, Kristof
Vandeputte, Bart
Scheldeman, Daan
Dumoleijn, Kim
출원인 / 주소
Taminco BVBA
대리인 / 주소
Carmen, Dennis V.
인용정보
피인용 횟수 :
0인용 특허 :
8
초록▼
Disclosed is a process for performing a chemical reaction selected from reductive amination and hydrogenation of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected
Disclosed is a process for performing a chemical reaction selected from reductive amination and hydrogenation of a first functional group in an organic feed substrate, which feed substrate comprises at least one further functional group containing a halogen atom, wherein the halogen atom is selected from the list consisting of chlorine, bromine, iodine, and combinations thereof, in the presence of hydrogen and a heterogeneous catalyst comprising at least one metal from the list of Pd, Rh, and Ru, together with at least a second metal from the list consisting of Ag, Ni, Co, Sn, Cu and Au. The process is preferably applied for the reductive amination of 2-chloro-benzaldehyde to form 2-chloro-benzyldimethylamine, as an intermediate in the production of agrochemically active compounds and microbiocides of the methoximinophenylglyoxylic ester series. Further disclosed is a composition rich in 2-chloro-benzyldimethylamine, further comprising an amount of 2-chloro-benzyl alcohol and being low in chlorotoluene isomers.
대표청구항▼
1. A composition comprising, as measured by gas chromatography, GC, a) at least 98.0% wt of 2-chloro-benzyl-dimethylamine,b) at most 0.40% wt of ortho-chloro toluene, andc) at least 0.05% wt of 2-chloro-benzyl alcohol,and wherein the composition is prepared from the reductive amination of ortho-chlo
1. A composition comprising, as measured by gas chromatography, GC, a) at least 98.0% wt of 2-chloro-benzyl-dimethylamine,b) at most 0.40% wt of ortho-chloro toluene, andc) at least 0.05% wt of 2-chloro-benzyl alcohol,and wherein the composition is prepared from the reductive amination of ortho-chloro benzaldehyde, and wherein the weights of water, solvent and any residual dimethyl amine are excluded from the composition. 2. The composition according to claim 1, comprising at least 98.5% wt of 2-chloro-benzyl-dimethylamine. 3. The composition according to claim 1, further comprising not more than 0.04% wt of 2-chloro dichloromethyl benzene. 4. The composition according to claim 1 comprising at least 0.07% wt of 2-chloro-benzyl alcohol. 5. The composition according to claim 1 comprising not more than 1.0% wt of 2-chloro-benzyl alcohol. 6. The composition according to claim 1 comprising no more than 0.20% wt of 2-chloro-benzaldehyde, as determined by gas chromatography, GC. 7. The composition according to claim 1, further comprising no more than 0.40% wt of 4-chloro-benzyl dimethylamine, as determined by gas chromatography, GC. 8. The composition according to claim 1 comprising no more than 0.35% wt of ortho-chloro toluene. 9. The composition according to claim 1, further comprising not more than 0.40% wt of benzyldimethylamine, as determined by gas chromatography, GC. 10. The composition according to claim 1, further comprising not more than 0.40% wt of 2-dimethylamino-benzyldimethylamine, as determined by gas chromatography, GC. 11. The composition according to claim 1, further comprising not more than 0.40% wt of benzaldehyde, as determined by gas chromatography, GC.
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이 특허에 인용된 특허 (8)
Druckrey Eike (Rossert DT) Knabe Bernd (Kelkheim ; Taunus DT) Lang Hans-Jochen (Altenhain ; Taunus DT) Babej Milos (Frankfurt am Main DT) Muschaweck Roman (Frankfurt am Main DT), Benzylamine derivatives and process for preparing them.
Deller Klaus (Hainburg DEX) Despeyroux Bertrand (Hanau DEX) Peldszus Erik (Hasselroth DEX) Kleinwaechter Beate (Hanau DEX), Catalyst for the selective hydrogenation of aromatic halonitro compounds to aromatic haloamines and a process for its pr.
Borner,Armin; Dingerdissen,Uwe; Kadyrov,Renat; Riermeier,Thomas; Tararov,Vitali, Method for the production of amines by reductive amination of carbonyl compounds under transfer-hydrogenation conditions.
Cordier Georges (Francheville FRX) Damon Jean-Pierre (Le Touvet FRX) Fouilloux Pierre (Caluire et Cuire FRX) Marion Philippe (Villeurbanne FRX), Raney-type catalysts for the hydrogenation of halonitroaromatic compounds.
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