Methods and systems for purifying one or more microbial cells and/or viruses from a biological sample are provided. The biological sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the
Methods and systems for purifying one or more microbial cells and/or viruses from a biological sample are provided. The biological sample is added to a well disposed in a medium. A potential is applied across the medium to cause the contaminants to enter one or more walls of the well, and retain the microbial cells and/or viruses in the well. The microbial cells and/or viruses can be removed from the well, and optionally adhered or fixed to a surface, or detected. In one embodiment, the microbial cells and/or viruses are retained in the well by embedding in the medium. The medium including the embedded microbial cells and/or viruses may be excised or otherwise removed and transferred to a glass slide or other solid surface. In some examples, a biological sample containing contaminants and one or more microbial cells is introduced to a well disposed in a porous filter medium, wherein the porous filter medium includes pores smaller than the one or more microbial cells, thereby preventing the one or more microbial cells from entering the porous filter medium.
대표청구항▼
1. A method of purifying one or more microbial cells in a biological sample, comprising: adding a biological sample containing contaminants and one or more microbial cells to a well disposed in a porous filter medium, wherein the porous filter medium comprises pores smaller than the one or more micr
1. A method of purifying one or more microbial cells in a biological sample, comprising: adding a biological sample containing contaminants and one or more microbial cells to a well disposed in a porous filter medium, wherein the porous filter medium comprises pores smaller than the one or more microbial cells, thereby preventing the one or more microbial cells from entering the porous filter medium;contacting the porous filter medium with a buffer disposed in one or more reservoirs adjacent to the porous filter medium to initiate diffusion;applying an electrical potential across the porous filter medium to cause the contaminants to enter the porous filter medium through one or more walls of the well, while retaining the one or more microbial cells in the well; andremoving the one or more microbial cells from the well. 2. The method of claim 1, wherein the one or more microbial cells are bacteria. 3. The method of claim 1, wherein the biological sample comprises cerebrospinal fluid or urine. 4. The method of claim 1, wherein the biological sample comprises blood or plasma. 5. The method of claim 1, wherein the biological sample comprises a respiratory specimen. 6. The method of claim 1, wherein the electrical potential is applied for about 5 minutes to about 15 minutes. 7. The method of claim 1, wherein the buffer is replenished prior to removing the one or more microbial cells from the well. 8. The method of claim 7, wherein the buffer comprises histidine and tris(hydroxymethyl)aminomethane. 9. The method of claim 1, further comprising adding a chemical agent to the biological sample to increase permeability of the porous filter medium to the contaminants. 10. The method of claim 1, further comprising applying a tangential flow to the porous filter medium to remove non-permeable contaminants from the surface of the porous filter medium. 11. The method of claim 1, further comprising concentrating in the well the one or more microbial cells. 12. The method of claim 11, further comprising repeating the adding step and the applying step prior to removing the one or more microbial cells from the well. 13. The method of claim 1, further comprising mixing the biological sample. 14. The method of claim 13, wherein the biological sample is mixed by stirring the sample, repeatedly passing the sample through a pipette tip, repeatedly forcing the sample through tubing connected to a syringe, or combinations thereof. 15. The method of claim 13, wherein the biological sample is mixed before application of the electrical potential, during application of the electrical potential, after application of the electrical potential, or combinations thereof. 16. The method of claim 1, wherein the electrical potential comprises a field polarity and the field polarity is switched according to a programmed sequence. 17. The method of claim 1, wherein the porous filter medium comprises polyvinylidene fluoride, track-etched polycarbonate, nitrocellulose, nylon, polyethersulfone, or combinations thereof. 18. The method of claim 1, wherein the pores of the porous filter medium are about 200 nm to about 2000 nm in diameter.
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Ayers John S. (Palmerston North NZX) Bethell Geoffrey S. (Palmerston North NZX) Hancock William S. (Palmerston North NZX) Hearn Milton T. W. (Dunedin North NZX), Activated matrix and method of activation.
Ayers John S. (Palmerston North) Bethell Geoffrey S. (Palmerston North) Hancock William S. (Palmerston North) Hearn Milton T. W. (Dunedin North), Activated matrix and method of activation.
Ackley Donald E. ; Swanson Paul D. ; Graham Scott O. ; Mather Elizabeth L. ; LeClair Timothy L. ; Butler William F., Advanced active electronic devices for molecular biological analysis and diagnostics.
Sheppard ; Jr. Norman F. ; Mian Alec ; Kellogg Gregory ; Kieffer-Higgins Stephen G. ; Carvalho Bruce L., Affinity binding-based system for detecting particulates in a fluid.
Ribi Hans O. (Hillsborough CA) Guion Todd (San Mateo CA) Shafer Paul T. (Campbell CA), Analyte detection with multilayered bioelectronic conductivity sensors.
Clarke David J. (Salisbury GBX) Zamani-Farahani Freidoun (Andover GBX), Analytical apparatus utilizing a colorimetric or other optically detectable effect.
Bashir,Rashid; Razouk,Laila R.; Morisette,Dallas Todd; Erimli,Bahadir, Apparatus and method for detecting live cells with an integrated filter and growth detection device.
Matsumura Paul M. ; Hyman Jones M. ; Jeffrey Scott R. ; Maresch Martin J. ; Thorpe Thurman C. ; Barron William G., Apparatus and method for detecting, quantifying and characterizing microorganisms.
Wu Hai-Ping (Chapel Hill NC) Sage ; Jr. Burton H. (Raleigh NC) Adrion Robert F. (Cary NC), Apparatus and method for the detection and classification of articles using flow cytometry techniques.
Simpson John W. ; Rothberg Jonathan M. ; Went Gregory T., Apparatus and method for the generation, separation, detection, and recognition of biopolymer fragments.
Ghaed Ali (4605 S. Chelsea La. Bethesda MD 20814) Leland Jonathan K. (14236 Amberleigh Ter. Silver Spring MD 20905) Zoski Glenn D. (10308 Tamarack Dr. Vienna VA 22181) Goodman Jack E. (3011 Third St., Apparatus and methods for carrying out electrochemiluminescence test measurements.
Wilson, Brian D.; Anderson, David L.; Davis, Matthew S.; Erickson, Matthew D.; Johnson, Alan N.; Maurer, Garrick A.; Rosen, Michael J.; Sauerburger, Mark F.; Schmidt, Daniel R.; Wiltsie, Joshua D., Assay cartridge with reaction well.
Clark Alexander W. ; Gladnick Paul ; Armstrong Robert E. ; Bachur Nicholas ; Berndt Klaus W. ; Livingston Dwight, Automated microbiological testing apparatus and methods therefor.
Gemmell, Bruce McLean; Mazza, John Charles; Gebrian, Peter Louis; Shmel, Jr., Nicholas Michael; Farina, Edward Francis; Vaidya, Hemant, Automated random access microbiological analyzer.
Carpenter Thomas S. (Cazenovia NY) Hand David D. (Cazenovia NY), Automated wire insulation cutting and stripping method with improved means to prevent conductor scoring.
Fanning Mark Joseph ; Gayral Jean-Pierre Bernard,FRX ; Morris Roger James ; Robinson Ron ; Seaton William Ernest ; Shine David B. ; Springer Paul, Automatic sample testing machine.
Blackburn Gary ; Creager Stephen E. ; Fraser Scott ; Irvine Bruce D. ; Meade Thomas J. ; O'Connor Stephen D. ; Terbrueggen Robert H. ; Vielmetter Jost G. ; Welch Thomas W., Binding acceleration techniques for the detection of analytes.
Kitchell Judith P. (71 Woodland Rd. Newton MA 02166) de Riel Stanton R. (550 Northwest 99 Way Pembroke Pines FL 33024), Biologically useful polymer preparations.
Cho, Yoonkyoung; Kim, Dogyoon; Lee, Beomseok; Park, Jongmyeon; Kim, Hyunmin; Lee, Yangui; Lee, Jong Gun, Cartridge containing reagent, microfluidic device including the cartridge, method of manufacturing the microfluidic device, and biochemical analysis method using the microfluidic device.
Roger Hammer ; William O. Reid, Jr. ; David Storvick ; Richard A. Riedel ; James S. Hutchison ; Daniel Kennedy ; John W. Stoughton ; James J. Ramey ; Glen T. Mathews, Cartridge-based analytical instrument with rotor balance and cartridge lock/eject system.
Edelmann Hermann (Tutzing-Unterzeismering DEX) Pasch Anton (Tutzing DEX) Klose Sigmar (Berg DEX) Haar Hans-Peter (Weilheim DEX) Mann Karlheinz (Weilheim DEX), Centrifugal analyzer rotor unit and insert elements.
Cook, Richard Alan; Cho, Sang; Davis, Charles Quentin; Dorsey, Kevin E; Harley, Jason Charles; Leland, Jonathan; Matikyan, Rober Krikor; Otten, Sjef; Peterman, Jeffrey Howard; Thomas, Brian B, Clinical diagnostic system including instrument and cartridge.
Robinson, Ronnie J.; Wilson, Mark S.; Ronsick, Christopher S.; Walsh, John D.; Hyman, Jones M.; Thorpe, Thurman C.; Clay, Bradford G., Combined detection instrument for culture specimen containers and instrument for identification and/or characterization of a microbial agent in a sample.
Williams, Gregory B.; Nothaft, Daniel M.; Enscoe, Glenn F.; Burtner, Kathleen N.; Kangas, Monte E., Combined rapid susceptibility assay and microorganism identification system.
Blanton, Ross Mitchell; Justin, Michael James; Bishop, James Clement; Yam, Jacky S.; Polster, Robert J.; Fanning, Mark Joseph, Compact, integrated system for processing test samples.
Blanton, Ross; Justin, Michael James; Bishop, James Clement; Yam, Jacky S.; Polster, Robert J.; Fanning, Mark Joseph, Compact, integrated system for processing test samples.
Karakelle Mutlu (Dayton OH) Zdrahala Richard J. (Miami Lakes FL), Composite membrane, method for its preparation and electrolyte sensor including same.
Mansour James D. (Raleigh NC) Schulte Thomas H. (Cary NC) Neece Vernon R. (Durham NC), Composition and method for rapid detection of microorganisms in clinical samples.
Matsumura Paul M. ; Hyman Jones M. ; Jeffrey Scott R. ; Maresch Martin J. ; Thorpe Thurman C. ; Barron William G., Device and method for microbial antibiotic susceptibility testing.
Hansen, Timothy Roy; Messina, Mark Anthony; Page, John Thulin; Borgoyn, Thomas Paul; Lentz, Ammon David; Novak, Robert Michael, Device for automatically adjusting the bacterial inoculum level of a sample.
Hansen, Timothy Roy; Messina, Mark Anthony; Page, John Thulin; Borgoyn, Thomas Paul; Lentz, Ammon David; Novak, Robert Michael, Device for automatically adjusting the bacterial inoculum level of a sample.
Hansen, Timothy; Messina, Mark Anthony; Page, John Thuin; Borgoyn, Thomas Paul; Lentz, Ammon David; Novak, Robert Michael, Device for automatically adjusting the bacterial inoculum level of a sample.
Hyman, Jones M.; Matsumura, Paul M.; Jeffrey, Scott R.; Maresch, Martin J.; Thorpe, Thurman C., Device for isolation and surface culture of microorganisms from bulk fluids.
J. Bruce Pitner ; John Jacob Hemperly ; Richard D. Guarino ; Magdalena Wodnicka ; David T. Stitt ; Gregory J. Burrell ; Timothy G. Foley, Jr. ; Patrick Shawn Beaty, Device for monitoring cells.
Pitner, J. Bruce; Hemperly, John Jacob; Guarino, Richard D.; Wodnicka, Magdalena; Stitt, David T.; Burrell, Gregory J.; Foley, Jr., Timothy G.; Beaty, Patrick Shawn, Device for monitoring cells.
Sandstrom Torbjorn (Molnlycke SEX) Stiblert Lars (Gothengurg CO SEX) Maul Diana M. (Thornton CO), Devices and methods for detection of an analyte based upon light interference.
Bogart Gregory R. (Fort Collins CO) Moddel Garret R. (Boulder CO) Maul Diana M. (Thornton CO) Etter Jeffrey B. (Boulder CO), Devices for detection of an analyte based upon light interference.
Wright Jeri D. (Dublin CA) Barclay Brian L. (Sunnyvale CA) Swanson David R. (Palo Alto CA), Dosage forms comprising polymers comprising different molecular weights.
Haugland Richard P. (Eugene OR) MacCoubrey Ian C. (Blacksburg VA) Moore Patrick L. (West Roxbury MA), Dual-fluorescence cell viability assay using ethidium homodimer and calcein AM.
Ozkan, Mihrimah; Esener, Sadik; Bhatia, Sangeeta, Electric-field-assisted fluidic assembly of inorganic and organic materials, molecules and like small things including living cells.
Ebersole Richard C. (Wilmington DE) DeCarolis John G. (Newark DE) McCormick Randy M. (Santa Clara CA), Electrophoretic method for the isolation and separation of microorganisms and cell populations.
Bjrk Nils A. N. (Tby SEX) Sandstrm Erland T. (Mlndal SEX) Stenberg Johan E. (Gothenburg SEX) Stiblert Lars B. (Gothenburg SEX), Ellipsometric method and apparatus for studying physical properties of the surface of a testpiece.
Claverys Jean-Pierre (Toulouse FRX) Mabilat Claude (Villeurbanne FRX), Genomic DNA fragment of Streptococcus pneumoniae, hybridization probe, amplification primer, reagent and metho.
Briggs Donald David ; Chary Srikanth Ranga ; Jen Shang-Chih David ; Schwartz Richard Merrill, High gradient magnetic device and method for cell separation or purification.
Nicoli David F. (448 Mills Way Goleta CA 93117) Elings Virgil B. (1155 Via Tranquilla Santa Barbara CA 93110), Immunoassay using optical interference detection.
Jing Cheng CN; Lei Wu ; Michael J. Heller ; Ed Sheldon ; Jonathan Diver ; James P. O'Connell ; Dan Smolko ; Shila Jalali ; David Willoughby, Integrated portable biological detection system.
Cohen Smadar (Petach-Tickva ILX) Bano Carmen (Valencia PA ESX) Visscher Karyn B. (State College PA) Chow Marie (Brookline MA) Allcock Harry R. (State College PA) Langer Robert S. (Newton MA), Ionically cross-linked polymeric microcapsules.
Pirrung Michael C. (Durham NC) Read J. Leighton (Palo Alto CA) Fodor Stephen P. A. (Palo Alto CA) Stryer Lubert (Stanford CA), Large scale photolithographic solid phase synthesis of an array of polymers.
Stimpson Donald I. (Gurnee IL) Gordon Julian (Lake Bluff IL) Hoijer Joanell V. (Arlington Heights IL), Light scattering optical waveguide method for detecting specific binding events.
Sielaff Bruce H. (Gales Ferry CT) Praglin Julius (East Lyme CT) McKie ; Jr. James E. (Ledyard CT) Longhenry David K. (East Lyme CT) Curtiss Alan C. (Old Lyme CT) Bidwell Charles B. (Madison CT), Method and apparatus for identifying microorganisms.
Stenberg Johan E. (Hedelundsragn 5 S-41743 Gteborg SEX) Stiblert Lars B. (vre Besvrsgatan 4 S-411 29 Gteborg SEX) Sandstrm Erland T. (Jungmansgaton 53 S-413 11 Gteborg SEX), Method and apparatus for studying surface properties.
Weiss, Gregory A.; Penner, Reginald M.; Tam, Phillip Y.; Yang, Li-Mei; Brigham, Tyler, Method and apparatus for target detection using electrode-bound viruses.
Halverson, Kurt J.; Wei, Ai-Ping; Qiu, Jean; Calhoun, Clyde D.; Berg, James G.; Bentsen, James G.; Johnston, Raymond P., Method and devices for detecting and enumerating microorganisms.
Nygren, B. Hakan; Sandstrom, E. Torbjorn; Stenberg, Johan E.; Stiblert, Lars B., Method and member for detecting and/or measuring the concentration of a chemical substance.
Robinson, Ronnie J.; Fanning, Mark Joseph; Philipak, Stanley Michael; Valentino, Anthony; Ammerman, Mike, Method for automated unloading of a microbial detection apparatus.
Robinson, Ronnie J.; Fanning, Mark Joseph; Valentino, Anthony; Ammerman, Mike; Philipak, Stanley Michael, Method for automated unloading of microbial detection apparatus.
Cleuziat, Philippe; Incardona, Sandra; Jay, Corinne, Method for cellular lysis of prokaryotes or eukaryotes or simultaneous cellular lysis of prokaryotes and eukaryotes.
Hari V. (Bloomfield Hills MI) Baunoch David A. (Pontiac MI) Das Pritam (Detroit MI), Method for detecting the presence of antibodies using gold-labeled antibodies and test kit.
Feng, Liping; Brasso, William B.; Shi, Song; Turng, Ben; Kircher, Susan M.; White, Vanda; Luper, Dyan; Rosales, Julie; Campbell, Gretta; Malick, Adrien, Method for direct and rapid identification of microorganisms and antimicrobial susceptibility testing from positive blood cultures.
Walsh, John; Hyman, Jones M.; Thorpe, Thurman; Clay, Bradford; Ronsick, Christopher, Method for separation, characterization and/or identification of microorganisms using spectroscopy.
De Brabander Marc J. (Zoersel BEX) Geuens Gustaaf M. A. (Mol BEX) Nuydens Rony M. (Vosselaar BEX) Moeremans Marc K. J. J. (Mol BEX), Method of visualizing individual submicroscopic metal particles.
Barbera-Guillem Emilio ; Nelson M. Bud, Methods and assay kits for detecting altered mononuclear cell phenotype related to a pro-tumor immune response.
Sosnowski Ronald G. ; Butler William F. ; Tu Eugene ; Nerenberg Michael I. ; Heller Michael J. ; Edman Carl F., Methods and procedures for molecular biological analysis and diagnostics.
Heller Michael James ; O'Connell James Patrick ; Juncosa Robert David ; Sosnowski Ronald George ; Jackson Thomas Ratcliffe, Methods for hybridization analysis utilizing electrically controlled hybridization.
Griner, Christopher Dallas; McDowell, Thomas Kenneth, Microbiological analyzer using colorimetric means for biochemical color and growth determinations.
Peter Krulevitch ; Harold D. Ackler ; Frederick Becker ; Bernhard E. Boser ; Adam B. Eldredge ; Christopher K. Fuller ; Peter R. C. Gascoyne ; Julie K. Hamilton ; Stefan P. Swierkowski ; Xia, Microfabricated AC impedance sensor.
Davis, Ronald W.; Javanmard, Mehdi; Mindrinos, Michael N.; Mok, Janine A., Microfluidic method for measurement or detection involving cells or biomolecules.
Carr Anthony H. (Bedford GBX) Badley Robert A. (Bedford GBX) Jobling Ian (Rushden GBX) Sands Thomas J. (Wellingborough GBX), Microorganism testing with a hydrolyzable fluorogenic substrate.
Egen Ned B. (Tucson AZ) Twitty Garland E. (Tucson AZ) Sammons David W. (Tucson AZ) Sharnez Rizwan (Tucson AZ), Multi-modality electrical separator apparatus and method.
Lowery, Jr., Thomas Jay; Audeh, Mark John; Chepin, James Franklin; Dhanda, Rahul; Neely, Lori Anne; Rittershaus, Charles William, NMR systems and methods for the rapid detection of analytes.
Olesen, Tom; Valvik, Martin Christian; Larsen, Niels Agersnap; Sandberg, Rasmus Helmsby, Optical sectioning of a sample and detection of particles in a sample.
Lundstrm Kurt I. (Faergaregatan 10 S-582 52 Linkoeping SEX) Arwin Hans R. (Linkoeping SEX) Rieke Erwin (Seeheim-Jugenheim DEX) Sielaff Gnter (Bensheim DEX) Hennrich Norbert (Darmstadt DEX), Optical specific binding assay with reflection of polarized electromagnetic radiation.
Smithwick ; Jr. Edward L. (Indianapolis IN) Frederickson Robert C. A. (Indianapolis IN) Shuman Robert T. (Greenwood IN), Pharmacologically active peptides.
Giese Roger W. (56 Oakland Ave. Quincy MA 02170), Process for applying multiple layers of a protein and a ligand extender to a surface and to the multiple-layer system.
Erlich Henry A. (Oakland CA) Horn Glenn (Emeryville CA) Saiki Randall K. (Richmond CA) Mullis Kary B. (Kensington CA), Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids.
Weaver James C. (Sudbury MA) Bliss Jonathan G. (Somerville MA) Williams Gregory B. (Tewksbury MA) Powell Kevin T. (Boston MA) Harrison Gail I. (Watertown MA), Process for rapidly enumerating viable entities.
Kwon, Sunghoon; Jung, Yong-Gyun; Choi, Jung Il; Na, Hun Jong, Rapid antibiotic susceptibility testing system based on bacterial immobilization using gelling agent, antibiotic diffusion and tracking of single bacterial cells.
Gomm, Cordell Kay; Luoma, II, Robert Paul; Arnquist, David Charles; Johnson, Ryan Patrick, Reagent and sample handling device for automatic testing system.
Schutt Ernest G. (Long Valley NJ) Dondero Richard S. (Riverdale NJ) Hansen William P. (Middleboro MA) Hovorka George B. (Hyde Park MA) Meyer Raymond E. (Arlington MA) Utberg Karin L. (Bridgewater NJ), Scattered total internal reflectance immunoassay system.
Goldberg, David A.; Howson, David C.; Metzger, Steven W.; Buttry, Daniel A.; Saavedra, Steven Scott, Sensitive and rapid determination of antimicrobial susceptibility.
Goldberg, David A.; Howson, David C.; Metzger, Steven W.; Buttry, Daniel A.; Saavedra, Steven Scott, Sensitive and rapid determination of antimicrobial susceptibility.
Goldberg, David A.; Howson, David C.; Metzger, Steven W.; Buttry, Daniel A.; Saavedra, Steven Scott, Sensitive and rapid determination of antimicrobial susceptibility.
Goldberg, David A.; Howson, David C.; Metzger, Steven W.; Buttry, Daniel A.; Saavedra, Steven Scott, Sensitive and rapid determination of antimicrobial susceptibility.
Paul M. Matsumura ; Jones M. Hyman ; Scott R. Jeffrey ; Martin J. Maresch ; Thurman C. Thorpe ; William G. Barron, Susceptibility plates for microbial antibiotic susceptibility testing.
Bishop, James C.; Guerra, Lawrence; Robinson, Ronnie J.; Fanning, Mark J.; Robbins, David M.; Taubert, Tomasz; Justice, Christopher D., System and method for agitation of multiple specimen containers.
Weiner, Nathan K.; Odoy, Patrick J.; Schultz, Eric; Jones, Mark; Overbeck, James T.; DeWeerd, Herman; Stura, David A.; Bukys, Albert K.; Woolaver, Tim J.; Regan, Thomas P.; Bradbury, David; McKenzie, Eric E.; DiPaolo, Roger; Miles, Christopher; Katz, Joel M.; Ksenia, Oleinik-Ovod, System and method for scanning of probe arrays.
Demirev, Plamen A.; Hagan, Nathan A.; Antoine, Miquel D.; Lin, Jefffrey S.; Feldman, Andrew B., System for determining drug resistance in microorganisms.
Robinson, Ronnie J.; Wilson, Mark S.; Ronsick, Christopher S.; Walsh, John D.; Hyman, Jones M.; Clay, Bradford G., System for rapid identification and/or characterization of a microbial agent in a sample.
Boeufgras, Jean-Marc; Lazzarini, Annie; Peyret, Michel, System for validation and interpreting results of antimicrobial susceptibility tests of micro-organisms.
Demirev, Plamen A.; Hagan, Nathan A.; Antoine, Miquel D.; Lin, Jeffrey S.; Feldman, Andrew B., Systems and methods for determining drug resistance in microorganisms.
Kleiner Hans-Jerg (Kronberg/Taunus DEX) Kloss Gerhard (Kelkheim DEX) Molter Michael (Schwalbach DEX) Schwarz Alexander (Flrsheim am Main DEX) Thamm Horst-Dieter (Kelkheim DEX), Technetium-99m triphosphonates and tetraphosphonates for the scintigraphic visualization of res-containing organs and ly.
Song Suk-zu (Flanders NJ) Rashidbaigi Zahra A. (Nutley NJ) Nesbitt Russell U. (Somerville NJ) Fawzi Mahdi B. (Flanders NJ), Transdermal drug delivery device comprising copolymers of N-morpholinoethyl methacrylate and 2-hydroxylmethacrylate.
Leunissen Johannes Leonardus Maria,BEX ; De Brabander Marc Joris,BEX ; Van de Plas Petrus Franciscus Elisabeth Maria,NLX, Universally applicable detection system based on ultra small colloidal metal particles.
Cole Susan M. (Minneapolis MN) Garbe James E. (Inver Grove Heights MN) Woodson Lewis P. (Eagan MN), Water-insoluble polysaccharide hydrogel foam for medical applications.
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