Methods and systems for improving the reliability of orthogonally redundant sensors
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61B-005/00
A61B-005/145
A61M-005/142
A61M-005/172
A61B-005/1455
A61B-005/1459
A61B-005/1468
A61B-005/1473
A61B-005/1495
C12Q-001/00
G01N-021/00
G01N-021/59
G01N-021/84
G01N-027/27
G01N-033/49
G01N-033/66
G01N-027/327
G01N-027/416
출원번호
US-0483404
(2017-04-10)
등록번호
US-10258264
(2019-04-16)
발명자
/ 주소
Varsavsky, Andrea
Li, Xiaolong
Liu, Mike C.
Zhong, Yuxiang
Yang, Ning
출원인 / 주소
MEDTRONIC MINIMED, INC.
대리인 / 주소
Pillsbury Winthrop Shaw Pittman LLP
인용정보
피인용 횟수 :
0인용 특허 :
82
초록▼
Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via
Methods and systems for sensor calibration and sensor glucose (SG) fusion are used advantageously to improve the accuracy and reliability of orthogonally redundant glucose sensor devices, which may include optical and electrochemical glucose sensors. Calibration for both sensors may be achieved via fixed-offset and/or dynamic regression methodologies, depending, e.g., on sensor stability and Isig-Ratio pair correlation. For SG fusion, respective integrity checks may be performed for SG values from the optical and electrochemical sensors, and the SG values calibrated if the integrity checks are passed. Integrity checks may include checking for sensitivity loss, noise, and drift. If the integrity checks are failed, in-line sensor mapping between the electrochemical and optical sensors may be performed prior to calibration. The electrochemical and optical SG values may be weighted (as a function of the respective sensor's overall reliability index (RI)) and the weighted SGs combined to obtain a single, fused SG value.
대표청구항▼
1. A continuous glucose monitoring system comprising: an orthogonally redundant glucose sensor device comprising an optical glucose sensor and an electrochemical glucose sensor; anda transmitter operatively coupled to said electrochemical and optical glucose sensors and having a housing, wherein the
1. A continuous glucose monitoring system comprising: an orthogonally redundant glucose sensor device comprising an optical glucose sensor and an electrochemical glucose sensor; anda transmitter operatively coupled to said electrochemical and optical glucose sensors and having a housing, wherein the transmitter includes sensor electronics in said housing, said sensor electronics including at least one physical microprocessor that is configured to: perform a status check on each of the electrochemical glucose sensor and the optical glucose sensor, wherein said status check on the optical glucose sensor is based on at least one of a previous cal ratio, a previous sensor accuracy, a sensitivity loss flag, and a dip flag for the optical glucose sensor;calculate a first reliability index for an output signal of the electrochemical sensor based on said status check for the electrochemical sensor;calculate a second reliability index for an output signal of the optical sensor based on said status check for the optical sensor;calibrate the output signal of the electrochemical sensor to obtain an electrochemical sensor glucose value (echem SG);calibrate the output signal of the optical sensor to obtain an optical sensor glucose value (optical SG);calculate a first weight based on said first reliability index and calculate a weighted echem SG based on said first weight;calculate a second weight based on said second reliability index and calculate a weighted optical SG based on said second weight; andcalculate a single, fused sensor glucose value based on said weighted echem SG and weighted optical SG. 2. The system of claim 1, wherein said weighted echem SG is calculated by multiplying said first weight by said echem SG, and wherein said weighted optical SG is calculated by multiplying said second weight by said optical SG. 3. The system of claim 1, wherein said single, fused sensor glucose value is calculated by adding said weighted echem SG to said weighted optical SG. 4. The system of claim 1, wherein the transmitter wirelessly transmits said single, fused sensor glucose value. 5. The system of claim 1, wherein the transmitter is configured to be worn on a body of a user. 6. The system of claim 1, further including a handheld monitor. 7. The system of claim 6, wherein the handheld monitor includes an integrated blood glucose meter. 8. The system of claim 7, wherein the transmitter wirelessly transmits said single, fused sensor glucose value to the hand-held monitor. 9. The system of claim 1, further including an insulin pump. 10. The system of claim 9, wherein the transmitter wirelessly transmits said single, fused sensor glucose value to the insulin pump. 11. The system of claim 10, wherein said glucose monitoring system is a closed-loop system. 12. The system of claim 1, wherein the optical glucose sensor includes an assay having a glucose receptor, a glucose analog, a first fluorophore, and a reference fluorophore different from said first fluorophore. 13. The system of claim 12, wherein said output signal of the optical glucose sensor is a ratio of the fluorescence signal from the first fluorophore to the fluorescence signal from the reference fluorophore. 14. The system of claim 1, wherein each of the electrochemical and optical sensors has a distal portion and a proximal portion, and wherein respective distal portions of the optical sensor and the electrochemical sensor are configured to be co-located within a user's body. 15. The system of claim 1, wherein said status check on the electrochemical glucose sensor is based on a value of said output signal of the electrochemical glucose sensor. 16. The system of claim 1, wherein said cal ratio is defined as a meter glucose value divided by a difference between the electrochemical glucose sensor's output signal and an offset. 17. The system of claim 1, wherein said status check on the optical glucose sensor is based on a value of said output signal of the optical glucose sensor. 18. The system of claim 1, wherein the first reliability index is calculated based on a reliability index for each of sensor dip, sensor noise, sensor sensitivity loss, sensor cal ratio, and sensor accuracy for the electrochemical glucose sensor, and the second reliability index is calculated based on a reliability index for each of sensor dip, sensor noise, sensor sensitivity loss, sensor cal ratio, and sensor accuracy for the optical glucose sensor. 19. The system of claim 18, wherein, for both the electrochemical glucose sensor and the optical glucose sensor, the reliability index for each of sensor dip and sensor sensitivity loss has a value of either 0 or 1.0. 20. The system of claim 18, wherein, for both the electrochemical glucose sensor and the optical glucose sensor, the reliability index for each of sensor noise, sensor cal ratio, and sensor accuracy has a value between 0 and 1, inclusive. 21. The system of claim 1, wherein said first weight is a linear function of said first reliability index, said second weight is a linear function of said second reliability index, or both. 22. The system of claim 1, wherein said first weight is a non-linear function of said first reliability index, said second weight is a non-linear function of said second reliability index, or both.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (82)
Chong, Colin A.; Griffin, Christopher G., Adhesive patch systems and methods.
Causey ; III James D. ; Kovelman Paul H. ; Purvis Richard E. ; Mastrototaro John J., Analyte sensor and holter-type monitor system and method of using the same.
Holker,James D.; Calle,Guillermo A.; Branch,Kevin D.; Mastrototaro,John J.; Van Antwerp,William P.; Van Antwerp,Nannette, Analyte sensor method of making the same.
Bcker Dirk (Heidelberg DEX) Haar Hans-Peter (Wiesloch DEX) Blasberg Peter (Weinheim DEX) Kotulla Reinhard (Lambsheim DEX), Analytical system for monitoring a substance to be analyzed in patient-blood.
Enegren, Bradley J.; Patel, Himanshu; Madzar, Bogdan; Yoon, Richard K.; Narang, Ajit S., Automobile physiological monitoring system and method for using the same.
Steil, Garry M.; Rebrin, Kerstin; Goode, Jr., Paul V.; Mastrototaro, John J.; Purvis, Richard E.; Van Antwerp, William P.; Shin, John J.; Talbot, Cary D., Closed loop system for controlling insulin infusion.
Bazargan, Afshin; Vazquez, Pablo; Monirabbasi, Salman; Kovelman, Paul H., Color detection system for detecting reservoir presence and content in device.
Malave, Luis J.; Estes, Mark C.; Yonemoto, Jay; Barlow, J. Jeffrey; Gross, Todd M.; Shin, John; Cheney, II, Paul S.; Dobbles, Mike; Hague, Clifford W.; Ruppert, Deborah; Wells, Kevin C., Communication station and software for interfacing with an infusion pump, analyte monitor, analyte meter, or the like.
Kimball Victor E. ; Lynch Laurie E. ; Pierskalla Irvin T. ; Porter Christopher H., In situ calibration system for sensors located in a physiologic line.
Mounce, R. Paul; Bente, IV, Paul F.; Hanson, Ian B.; Stutz, Jr., William H., Infusion medium delivery device and method with compressible or curved reservoir or conduit.
Mounce, R. Paul; Norton, Melissa D.; Guezuraga, Robert M.; Enegren, Bradley J.; Bente, IV, Paul F.; Hanson, Ian B.; Kavazov, Julian D.; Griffin, Christopher G.; Moberg, Sheldon B.; Holt, Mark D.; Maule, Susie E.; Kovelman, Paul H., Infusion medium delivery device and method with drive device for driving plunger in reservoir.
Bobroff, Randa M.; Kiliszewski, Lawrence; Lickliter, Hans; Hougton, Frederick C.; Safabash, Jason H.; McConnell, Susan M.; Marano, April A., Insertion device for an insertion set and method of using the same.
Walsh, Joseph C.; Heiss, Aaron M.; Noronha, Glenn; Vachon, David J.; Lane, Stephen M.; Satcher, Jr., Joe H.; Peyser, Thomas A.; Van Antwerp, William Peter; Mastrototaro, John Joseph, Long wave fluorophore sensor compounds and other fluorescent sensor compounds in polymers.
Cohen, Gary; Goldsmith, Joel; Roller, Pam S.; Widran, Sanford; Patterson, George W.; Daugherty, James R.; Van Antwerp, William P., Medical data management system and process.
Nielsen, Ole Christian; Radmer, Jim; Preuthun, Jan Harald; Ethelfeld, Erik Winkel; Rorvig, Simon; Bengtsson, Henrik, Medical skin mountable device and system.
Wang, Lu; Shah, Rajiv; Cooper, Kenneth W.; Yoon, Richard K.; Lee, Helen, Method and system for detecting age, hydration, and functional states of sensors using electrochemical impedance spectroscopy.
Moberg, Sheldon B.; Hanson, Ian B.; Talbot, Cary D.; Ireland, Jeffrey, Methods and apparatuses for detecting medical device acceleration, temperature, and humidity conditions.
Talbot, Cary D.; Moberg, Sheldon B.; Causey, III, James D.; Yonemoto, Jay A., Selective potting for controlled failure and electronic devices employing the same.
Talbot, Cary D.; Mastrototaro, John J.; Shah, Rajiv; Chernoff, Edward; Mueller, Jr., John C.; Shahmirian, Varaz; Purvis, Richard E.; Morgan, Wayne A.; Gottlieb, Rebecca K., Sensing system with auxiliary display.
Brauker, James H.; Carr-Brendel, Victoria E.; Goode, Paul V.; Kamath, Apurv Ullas; Thrower, James Patrick; Xavier, Ben, Signal processing for continuous analyte sensor.
Cooper, Kenneth W.; Choy, David Y.; Shah, Rajiv; Soundararajan, Gopikrishnan; Vejella, Ratnakar, System and method for determining the point of hydration and proper time to apply potential to a glucose sensor.
Estes, Mark C.; Talbot, Cary D.; Tolle, “Mike” Charles Vallet; Yonemoto, Jay A., System for providing blood glucose measurements to an infusion device.
Moberg, Sheldon B.; Hanson, Ian B.; Mounce, R. Paul; Bente, IV, Paul F.; Kavazov, Julian D., Systems and methods allowing for reservoir filling and infusion medium delivery.
Goode, Jr., Paul V.; Brauker, James H.; Kamath, Apurv U.; Thrower, James Patrick; Carr-Brendel, Victoria, Systems and methods for replacing signal artifacts in a glucose sensor data stream.
Mann, Alfred E.; Purvis, Richard E.; Mastrototaro, John J.; Causey, James D.; Henke, James; Hong, Peter; Livingston, John H.; Hague, Clifford W.; Hite, Brad T., Telemetered characteristic monitor system and method of using the same.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.