[미국특허]
Antibacterial and fungicidal peptide in which lysine and tryptophan residues are repeated, and use thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
C07K-005/103
C07K-007/06
C07K-005/11
C07K-007/08
A61K-038/00
출원번호
15833875
(2017-12-06)
등록번호
10301354
(2019-05-28)
우선권정보
KR-10-2011-0147577 (2011-12-30)
발명자
/ 주소
Park, Yoon Kyung
출원인 / 주소
Industry-Academic Cooperation Foundation, Chosun University
대리인 / 주소
Klarquist Sparkman, LLP
인용정보
피인용 횟수 :
0인용 특허 :
0
초록▼
The present invention relates to an antibacterial and fungicidal peptide in which a lysine and tryptophan dipeptide is repeated. More specifically, the antibacterial and fungicidal peptide of the present invention, in which lysine and tryptophan dipeptide is repeated four times, shows excellent anti
The present invention relates to an antibacterial and fungicidal peptide in which a lysine and tryptophan dipeptide is repeated. More specifically, the antibacterial and fungicidal peptide of the present invention, in which lysine and tryptophan dipeptide is repeated four times, shows excellent antibacterial activities with respect to gram-positive bacteria, gram-negative bacteria and antibiotic-resistant strains by affecting the inner membrane of harmful microorganisms, has remarkable fungicidal activities with respect to pathogenic fungi and antibiotic-resistant fungi, and shows little cytotoxicity, and thus can be useful for a pharmaceutical composition, a cosmetic composition, agricultural chemicals, a food preservative, a cosmetic preservative, and a pharmaceutical preservative.
대표청구항▼
1. A method for inhibiting bacterial or fungal activity, comprising the step of exposing bacteria or fungi to a pharmaceutically effective dose of the peptide KWKWKWKW-NH2 (SEQ ID NO: 3) in an amount that is safe for humans and sufficient to inhibit the bacterial or fungal activity, wherein the pept
1. A method for inhibiting bacterial or fungal activity, comprising the step of exposing bacteria or fungi to a pharmaceutically effective dose of the peptide KWKWKWKW-NH2 (SEQ ID NO: 3) in an amount that is safe for humans and sufficient to inhibit the bacterial or fungal activity, wherein the peptide has an —NH2 at the C-terminus. 2. The method according to claim 1, wherein the peptide is exposed to a pathogenic bacteria, and the pharmaceutically effective dose is sufficient to inhibit growth of the bacteria. 3. The method of claim 2, wherein the peptide is exposed to Gram positive bacteria. 4. The method according to claim 3, wherein the Gram-positive bacteria to which the peptide is exposed is Bacillus subtilis, Staphylococcus aureus or Listeria monocytogenes. 5. The method according to claim 2, wherein the peptide is exposed to Gram-negative bacteria. 6. The method according to claim 5, wherein the Gram-negative bacteria to which the peptide is exposed is Escherichia coli, Pseudomonas aeruginosa or Salmonella typhimurium. 7. The method according to claim 2, wherein the peptide is exposed to antibiotic-resistant strains of bacteria. 8. The method according to claim 7, wherein the antibiotic-resistant strain to which the peptide is exposed is antibiotic-resistant E. coli, antibiotic-resistant Salmonella, or antibiotic-resistant Staphylococcus. 9. The method according to claim 1, wherein the peptide is exposed to pathogenic fungi. 10. The method according to claim 9, wherein the pathogenic fungi to which the peptide is exposed is Candida albicans, Candida catenulate, Candida intermedia, Candida rugosa, Candida glabrata or Candida melibiosica. 11. The method according to claim 1, wherein the peptide is exposed to antibiotic-resistant fungi. 12. The method according to claim 11, wherein the antibiotic-resistant fungi to which the peptide is exposed is antibiotic-resistant Candida albicans. 13. The method of claim 1, wherein the peptide is exposed to the bacteria or fungi by administering the peptide to a subject having a bacterial or fungal infection, or by including the peptide in a composition to inhibit bacterial of fungal growth in the composition. 14. The method of claim 13, wherein the composition is a pharmaceutical composition, cosmetic, food or feed. 15. The method of claim 13, wherein the peptide is administered to the subject in a pharmaceutical composition. 16. The method of claim 15, wherein the pharmaceutical composition is administered orally or parenterally to the subject. 17. A method for treating disease caused by pathogenic bacteria or fungi, comprising the step of administering a pharmaceutically effective dose of an antibacterial or fungicidal peptide consisting of KWKWKWKW-NH2 (SEQ ID NO: 3), with an NH2 at the C-terminus, to a subject having the disease caused by the pathogenic bacteria or fungi, wherein the pharmaceutically effective dose is sufficient to inhibit growth of the pathogenic bacteria or fungi. 18. The method of claim 1, wherein the dose is 0.01-100 mg/kg.
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