초록

본 연구는 전산유체역학적인 방법과 in vitro 실험을 수행하여 동맥분지혈관내 혈액유동특성과 혈관질환의 상관관계를 규명하고자 하였다. 전산유체역학척인 방법으로는 유한체적법을 이용하고 in vitro 실험에서는 뉴턴 및 비뉴턴유체의 유동현상을 PIV를 이용하여 가시화하여 수치시뮬레이션 결과를 검증할 계획이다. 실험에서 많이 이용되는 혈액대용유체의 유동특성을 혈액의 경우와 비교하여 유변학적 특성이 다른 유체를 실험에 이용할 수 있는지의 가능성도 검토하고자 한다. 또한 혈관의 컴플라이언스를 고려한 혈액유동특성도 함께 고찰하고자 한다.

Abstract ▼

In this study. the relationships between blood flow characteristics in the bifurcated arteries and arterial diseases were investigated using. the CFD techniques and in vitro experiments. Blood flow characteristics were simulated using the finite volume predictions. In the experiments, the rheologica

In this study. the relationships between blood flow characteristics in the bifurcated arteries and arterial diseases were investigated using. the CFD techniques and in vitro experiments. Blood flow characteristics were simulated using the finite volume predictions. In the experiments, the rheological properties were measured using a capillary tube viscometer and the flow phenomena for the Newtonian and non-Newtonian fluids were effectively visualized with the PIV system, and the results of the finite volume predictions were verified using the PIV measurements. This study also conducted the modelling of pulsatile blood flow in the blood vessel with compliance. The "capillary tube viscometer concept H was applied to measure blood viscosity, and the effect of physical vibration on blood viscosity was examined. For the computer Simulations the geometric configurations of the bifurcated arteries were obtained from the biplanar angiograms. The inlet velocity and the pressure waveforms were acquired by in vivo data of the Intravascular Doppler method. In order to investigate the mechanism of the atherosclerotic formation and its development, blood flow characteristics such as the velocity, the pressure, the shear stress distributions and the recirculation regions in the bifurcated arteries were analyzed.

목차 Contents

• 1. 제출문...3
• 2. 연구계획서 요약문(국문)...4
• 3. 연구내용...5
• 가. 연구결과 요약문(국$\cdot$영문)...5
• 나. 서론...7
• 다. 연구방법 및 이론...9
• 라. 결과 및 고찰...17
• 마. 결론...36
• 바. 인용문헌...37
• 4. 논문발표목록서 및 자체평가서...40