초록

본 연구에서는 소구경 인공혈관용 재료개발을 위하여 항혈전성 재료에 관한 연구를 행하였다. 본 연구에서 개발한 항응혈성 재료는 gelatin/carrageenan blends, 인산화 셀룰로스, 슬폰화 PVA, PU/PVA blends, polyphosphazene 등이 있다.

Abstract ▼

The ideal vascular graft would be biocompatible, be nonthrombogenic, have long-term potency, be durable yet compliant, be infection resistant, and be technically facile. There is no ideal artificial graft available for small-vessel replacement. Therefore, we have studied for developing small-diamete

The ideal vascular graft would be biocompatible, be nonthrombogenic, have long-term potency, be durable yet compliant, be infection resistant, and be technically facile. There is no ideal artificial graft available for small-vessel replacement. Therefore, we have studied for developing small-diameter vascular graft. For this, we have developed biocompatible and nonthrombogenic materials to make a small-diameter vascular graft. The materials developed in this study were gelatin/carrageenan blends, phosphorylated cellulose, sulfated polyvinylalcohol, polyurethane/polyvinylalcohol blends, and polyphosphazenes. Blood compatibility of gelatin/carrageenan blends was better than that of gelatin as a control, while its tissue compatibility was similar with gelatin's. Platelet adhesion on the phosphorylated cellulose was lower than that on cellulose. The others were synthesized and will be tested at the next project year.

목차 Contents

• 제1장 서론...13
• 제2장 기술정보수집...17
• 제1절 의료용 고분자...17
• 1. 생체 적합성...18
• 2. 혈액 적합성 고분자...18
• 3. 세포 친화성 고분자...23
• 제2절 연구 동향...25
• 제3장 연구개발수행 내용 및 결과...29
• 제1절 Polyelectrolyte Complex를 이용한 항응혈성 고분자의 개발...29
• 제2절 인산화 셀룰로스...35
• 제3절 음이온성 폴리에칠렌...53
• 제4절 슬폰화 PVA...58
• 제5절 PU/PVA 블랜드...60
• 제6절 생체친화성 생분해성 고분자개발...63
• 제7절 동물실험...73
• 제4장 연구개발목표 달성도 및 대외기여도...124
• 제5장 연구개발결과의 활용계획...126
• 제6장 참고문헌...128