![GPAT inhibitory activity of EtOH extract and solvent fraction from Myristicae Semen. GPAT activity on [14C]glycerol-3-phosphate in the absence (control) and presence of EtOH extract (MS-E) and solvent fraction (MS-C, MS-H) from the MS. Values are mean ± SE (n=3)](https://nrms.kisti.re.kr/bitextimages/TRKO201300020769/TRKO201300020769_146_image_1.png "GPAT inhibitory activity of EtOH extract and solvent fraction from Myristicae Semen. GPAT activity on [14C]glycerol-3-phosphate in the absence (control) and presence of EtOH extract (MS-E) and solvent fraction (MS-C, MS-H) from the MS. Values are mean ± SE (n=3)")
![Inhibitory effects of EtOH extract and CHCl3 fraction on triacylglycerol formation by [14C] glycerol of in HepG2 cells. HepG2 cells (1☓105cells/ml) were incubated in the absence (control) or presence of MS-E, MS-C or BBR (15 μg/ml) with [1-14C] glycerol for 6h at 37°C. BBR (berberine) was used as a positive controls.](https://nrms.kisti.re.kr/bitextimages/TRKO201300020769/TRKO201300020769_148_image_1.png "Inhibitory effects of EtOH extract and CHCl3 fraction on triacylglycerol formation by [14C] glycerol of in HepG2 cells. HepG2 cells (1☓105cells/ml) were incubated in the absence (control) or presence of MS-E, MS-C or BBR (15 μg/ml) with [1-14C] glycerol for 6h at 37°C. BBR (berberine) was used as a positive controls.")
![Inhibitory effects of compound 2 and 3 on triacylglycerol formation by [14C] glycerol of in HepG2 cells. HepG2 cells (1☓105cells/ml) were incubated in the absence (control) or presence of compound 2, 3 or BBR (15 μg/ml) with [1-14C]glycerol for 6h at 37°C. BBR (berberine) was used as a positive controls. Values are expressed as percentages of control and are means ± SE (n=3)](https://nrms.kisti.re.kr/bitextimages/TRKO201300020769/TRKO201300020769_149_image_1.png "Inhibitory effects of compound 2 and 3 on triacylglycerol formation by [14C] glycerol of in HepG2 cells. HepG2 cells (1☓105cells/ml) were incubated in the absence (control) or presence of compound 2, 3 or BBR (15 μg/ml) with [1-14C]glycerol for 6h at 37°C. BBR (berberine) was used as a positive controls. Values are expressed as percentages of control and are means ± SE (n=3)")
![Inhibitory effects of SC-E, SC-C on triglyceride formation in human hepatoma, HepG2 cells. HepG2 cells (5☓104cells/500μl) were incubated in the absence (control) or presence of SC-E, SC-C (10, 30μg/ml) or AICAR (1 mM) with [1-14C] acetate for 6 h at 37°C. Intracellular [14C] lipids were extracted and analysed as indicated in Materials and Methods. AICAR (5-aminoimidazole-4-carboxamide 1-β-ribofuranoside), AMP-activated protein kinase (AMPK) activator, was used as a positive controls. Values are expressed as percentages of control and are means ± SE (n=3)](https://nrms.kisti.re.kr/bitextimages/TRKO201300020769/TRKO201300020769_154_image_2.png "Inhibitory effects of SC-E, SC-C on triglyceride formation in human hepatoma, HepG2 cells. HepG2 cells (5☓104cells/500μl) were incubated in the absence (control) or presence of SC-E, SC-C (10, 30μg/ml) or AICAR (1 mM) with [1-14C] acetate for 6 h at 37°C. Intracellular [14C] lipids were extracted and analysed as indicated in Materials and Methods. AICAR (5-aminoimidazole-4-carboxamide 1-β-ribofuranoside), AMP-activated protein kinase (AMPK) activator, was used as a positive controls. Values are expressed as percentages of control and are means ± SE (n=3)")
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| 주관연구기관 | 한국생명공학연구원 화학생물연구센터 |
|---|---|
| 연구책임자 | 안종석 |
| 참여연구자 | 이현선 , 오세량 , 이형규 , 이정준 , 홍영수 , 김보연 , 장재혁 , 김종평 , 김영국 , 권두한 , 안경섭 , 김재화 , 정동호 , 윤갑석 , 김영주 , 이중구 , 류인자 , 권옥경 , 김두영 , 김정희 |
| 보고서유형 | 최종보고서 |
| 발행국가 | 대한민국 |
| 언어 | 한국어 |
| 발행년월 | 2012-03 |
| 과제시작연도 | 2011 |
| 주관부처 | 미래창조과학부 KA |
| 사업 관리 기관 | 한국생명공학연구원 Korea Research Institute of Bioscience and Biotechnology |
| 등록번호 | TRKO201300020769 |
| 과제고유번호 | 1345165698 |
| DB 구축일자 | 2013-09-21 |
| 키워드 | 염증,천식,비만당뇨,암,타겟,전임상후보물질,식물,미생물,대사산물inflamation,asthma,obesity-diabetes,cancer,target,drug candidate,plant,inflamation,asthma,obesity-diabetes,cancer,target,drug candidate,plant |
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