1. 해양 • 극한 생물자원 확보 및 자원뱅크 운용 ○ 해양미생물자원 1,093종 6,098주 확보, DB 구축 및 웹 서비스분양 ○ 해양동식물자원 430 여종 확보, DNA 분자마커 분석 2. 해양 • 극한생물 유전체 해독 및 기능 분석 유용 유전자원 발굴 ○ 해양 동 • 식물 12종, 미생물 35종 43주의 유전체 해독 ○ 해양 환경유전체 7.7 Gb 확보 및 유용 운전자원 검색 ○ 해양유전체정보 정보시스템 구축 및 정보 서비스 3. 환경 변화에 따른 해양∙극한 생물의 적응 및 유전자 발현
1. 해양 • 극한 생물자원 확보 및 자원뱅크 운용 ○ 해양미생물자원 1,093종 6,098주 확보, DB 구축 및 웹 서비스분양 ○ 해양동식물자원 430 여종 확보, DNA 분자마커 분석 2. 해양 • 극한생물 유전체 해독 및 기능 분석 유용 유전자원 발굴 ○ 해양 동 • 식물 12종, 미생물 35종 43주의 유전체 해독 ○ 해양 환경유전체 7.7 Gb 확보 및 유용 운전자원 검색 ○ 해양유전체정보 정보시스템 구축 및 정보 서비스 3. 환경 변화에 따른 해양∙극한 생물의 적응 및 유전자 발현 연구 ○ 환경에 따른 해양 미생물의 특이 대사 경로 규명 ○ 해양광합성센균(초미소 남조세균) 분포, 유전자 교환, 물질순환 등) 4. 해양∙극한 유전자 산물인 단백질의 구조 및 기능 규명 ○ 해양∙극한 생물 특이 대사나 유용 대사 관련 단백질들의 3차원 구조규명 5. 해양유전체 기반 해양바이오소재 개발 ○ DNA 증폭효소, 아미노산 전환효소, 에스터라제 등 ○ DNA 중합효소 상용화, 바이오 수소 생산기술 spin-off
Abstract▼
IV. Results 1. Operation of marine and extreme bioresources collection ◦ Construction & operation of On-line DB & distribution system ◦ Acquiring and managing 6,098 microorganisms belongs to 1,138 genera ◦ Transferring microbial bioresources and managing systems to Marine BioResources Ba
IV. Results 1. Operation of marine and extreme bioresources collection ◦ Construction & operation of On-line DB & distribution system ◦ Acquiring and managing 6,098 microorganisms belongs to 1,138 genera ◦ Transferring microbial bioresources and managing systems to Marine BioResources Bank program ◦ Acquiring 30 echnoderms, 30 annelida, 60 porifera, 19 cnidaria, 48 molusca, & 20 nematods genera as bioresources and analyzing DNA barcode for selected 112 genera 2. Genomics of marine organisms ◦ Genomes and/or transcriptomes of 12 marine eukaryotes and 43 microbes belonging to 35 genera was analyzed ◦ Establishing web-service system for acquired genomic information ◦ Revealing novel energy metabolism, novel genetic resources, and evolution patterns of hyperthermophilic archaea via genomics and comparative genomic analysis ◦ De novo sequencing of Minke whale genome ◦ Acquiring 138 Mbp genome data from Gelidium vagum and 73 Mbp from red alga Gracriliopsis chorda, and 47 Gbp transcriptome data from G. vagum and 23 Gbp from G. chorda. ◦ Developing DNA modification enzymes, hydrolyzing enzymes for carbohydrates, lipids, proteins & epoxide and enzymes for modification of chemicals from genomic resources 3. Studies on microbial adaptation on environments via NGS system ◦ Clue of exchange genomic informations via Extracellular vesicles from Thermococcus onnurineus NA1, Flavobacteria etc. was observed ◦ The tubeworm harnessed energy from the chemoautotrophic bacterial endosymbionts which possessed two different carbon xation pathways, the fi CBB cycle and the rTCA cycle ◦ Distribution patterns of pico cyanobacteria such as genera Prochlorococcus and Synechococcus in oligotrophic open oceans and in coastal and upwelling areas was revealed via amplicon study and genomic differences in each Synechococcus clade was analysed using NGS system ◦ Anaerobic methane oxidation at sulfate-methane transition zone (SMTZ) was driving by consortium of methane oxidizing archaea and nitrate oxidizing bacteria in Ulleung Basin was revealed via amplicon study using NGS system 4. Characterization of proteins on the basis of their structures ◦ Structure determinations of proteins related to biotechnolgy or pathogenesis ◦ Structure-based functional studies of hypothetical proteins ◦ Revealing the molecular basis for metal sensing and DNA recognition of metalresponsive transcription factors ◦ Development of de novo phasing method using zinc anomalous scattering ◦ Acquire 20 protein crystal, solve 18 protein structure and publish more than 20 articles on SCI journals 5. Establishment of marine bio-active compounds screening system based on genomic information ◦ Revealing repression mechanism of DRAK1 & DRAK2 proteins on TGF-beta receptor, regulation mechanism of novel protein binding to DARK proteins and establishing cell based screening system ◦ Function of MEST gene, conserved in microbes to human, involved in occurrence, spreading, and EMT relatedness of breast cancer and relationship between cancer stem cell and breast cancer subtype was revealed ◦ Standardization of screening system using fruit fly ◦ Revealing regulatory system of genes involved in aminoglucoside resisteacy expression network of based on genomic and proteomic information.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.