초록

연구결과
국내 재배되고 있는 식물자원들을 in vitro assay를 통해 뇌세포 신경전달물질 분해효소 활성을 저해하는 기능을 가지고 있는 시료로 자소엽을 선정하였고, 활성성분을 분리ㆍ정제하는 과정에서 in vivo assay를 통해 효능을 확인하였으며, 각각 독성검사 결과 무독성의 물질임을 확인하였다. 또한 각각의 시료를 이용하여 시제품을 만들어 공업적 실용화 가능성을 확인하였다.

Abstract ▼

Result
The cholinergic hypothesis of Alzheimer’s disease (AD) has provided rationale for the present pharmaco-therapy of the disease, in an attempt to reduce the cognitive decline caused by cholinergic deficits. Nevertheless, the search for efficacious and long-acting acetylcholinesterase (AChE)

Result
The cholinergic hypothesis of Alzheimer’s disease (AD) has provided rationale for the present pharmaco-therapy of the disease, in an attempt to reduce the cognitive decline caused by cholinergic deficits. Nevertheless, the search for efficacious and long-acting acetylcholinesterase (AChE) inhibitors that exert minimal side effects in AD patients is still developing. AChE inhibitors are currently approved therapy for the treatment of AD. The antioxidant usage is another approach for treating AD. It is believed that antioxidants act by lowering free radical production and oxidative injury to the brain. Ethanol extracts of edible traditional Korean plants were tested for in vitro AChE inhibition and antioxidant activity. The Perilla frutescens showed significant inhibitory effect against AChE and oxidative stress. By consecutive fractionation of Perilla frutescens, the active component was finally identified as polyphenol group which have a phenoling structure. To search the effect Perilla frutescens on trimethyltin(TMT)-induced learning and memory impairment in mice, in vivo behavioral tests were performed.
These results indicate that Perilla frutescens is great potential to search for novel usage of these medicinal plants for the treatment of AD.

목차 Contents

• 중견연구자지원사업(핵심연구) 최종보고서 ... 1
• 목 차 ... 3
• 연구계획 요약문 ... 4
• 연구결과 요약문 ... 5
• 한글요약문 ... 5
• SUMMARY ... 6
• 연구내용 및 결과 ... 7
• 1. 연구개발과제의 개요 ... 7
• 2. 국내외 기술개발 현황 ... 11
• 3. 연구수행 내용 및 결과 ... 13
• 4. 목표달성도 및 관련 분야에의 기여도 ... 50
• 5. 연구결과의 활용계획 ... 55
• 6. 연구과정에서 수집한 해외과학기술정보 ... 56
• 7. 주관연구책임자 대표적 연구실적 ... 57
• 8. 참고문헌 ... 58
• 9. 연구성과 ... 60
• 10. 기타사항 ... 64
• 끝페이지 ... 69