초록

이중 에너지 기법을 이용한 폐관류 CT에서 얻어지는 폐관류 지도로부터 정량적으로 산출한 각 폐엽의 폐관류 지수로 술후 폐기능을 예측한 결과 폐관류 신티그래피를 이용한 기존의 폐기능 예측치에 필적하는 결과를 얻었다. 폐엽절제술을 시행받을 폐암환자에서 술전 검사로 이중 에너지 기법을 이용한 폐관류 CT를 얻음으로써 병기 결정과 동시에 술후 폐기능을 예측 할 수 있으므로 추가적인 폐신티그래피로 인한 환자의 피폭을 줄일수있으며 진단검사의 비용을 절감할 수 있다.

Abstract ▼

PURPOSES: Prediction of postoperative lung function is important in preoperative evaluation of patients with lung cancer. Perfusion scintigraphy is the current method to assess the fractional contribution of lung function of the remaining lung. We developed automatic lobe segmentation software and a

PURPOSES: Prediction of postoperative lung function is important in preoperative evaluation of patients with lung cancer. Perfusion scintigraphy is the current method to assess the fractional contribution of lung function of the remaining lung. We developed automatic lobe segmentation software and applied it to perfusion map of dual-energy CT for obtaining the exact lobe-based fractional contribution of perfusion. We compared the results of CT and perfusion scintigraphy for predictions of postoperative forced expiratory volume in 1 sec (FEV1) in patients with lung cancer.
MATERIALS AND METHODS: Sixty patients with lung cancer undergoing anatomic lung resection with preoperative dual-energy CT, pulmonary function test and perfusion scintigraphy were enrolled. We obtained gray-scale perfusion map from dual-energy CT and automatically segmented each lobe using in-house software. Volume of iodine of each pixel was calculated and the ratio of volume of iodine for each lobe was obtained. Prediction was calculated from preoperative FEV1 multiplied by the fractional contribution of volume of iodine of the remaining lung. Predicted postoperative FEV1 of dual-energy CT was compared with that of perfusion scintigraphy. Postoperative FEV1 was used as reference standard.
RESULTS: In preliminary results among sixty patients, the error rate of predicted postoperative FEV1 of dual-energy CT showed comparable error rate with that of perfusion scintigraphy (8.5 % and 5.9%, respectively).
CONCLUSIONS: Fractional contribution of remaining lung after lobectomy in patients with lung cancer can be exactly obtained from perfusion map of dual-energy CT by using automatic lobe segmentation software. Perfusion CT using dual-energy CT will be useful in terms of accuracy of prediction of postoperative pulmonary functions in patients with lung cancer. This technique may provide simultaneously the information about cancer staging and prediction of postoperative pulmonary function without additional radiation exposure to patients and may allow the avoid of pulmonary perfusion scintigraphy.

목차 Contents

• 표지 ... 1
• I. 총 괄 현 황 ... 2
• 제출문 ... 3
• 보고서 요약서 ... 4
• 요약문 ... 5
• SUMMARY ... 6
• 6. 연구성과 실적 및 향후 계획 ... 7
• 7. 참여연구원 현황표 ... 11
• Ⅱ. 총괄연구과제 연구결과 ... 12
• 1. 연구개발과제의 배경 및 필요성 ... 13
• 2. 국내외 기술개발 현황 ... 14
• 3. 연구개발과제의 추진체계 ... 22
• 4. 연구개발수행 내용 및 결과 ... 24
• 5. 목표달성도 및 관련분야 기여도 ... 32
• 6. 향후 연구성과 추진계획 ... 33
• 8. 연구개발결과의 활용계획 ... 34
• 9. 연구개발과정에서 수집한 해외과학기술정보 ... 34
• 10. 참고문헌 ... 34
• Ⅳ. 첨부서류 ... 37
• 끝페이지 ... 39