초록 ▼

본 연구는 아토피피부염과 접촉피부염의 유발원인 및 발병기전 규명에 따라 새로운 면역조절제 개발의 기초를 확고히 하였고 기존의 스테로이드제를 대체할 수 있는 천연물 폴리페놀 소재를 이용해 항아토피,항아토피 천연물 신약후보물질의 발견, 효능탐색, 합성, 기전연구를 통해 데이터베이스 확립 및 오염 접촉형 피부질환의 효율적 관리체계를 구축하였으며, 천연물 신약개발에 따른 새로운 노하우를 축적으로 학문적기반을 구축하였음. 또한 임상시료 확보 및 분자역학 연구를 통해 아토피피부염과 접촉피부염의 새로운 진단키트를 개발하였고 이를 통해 의료비 절

본 연구는 아토피피부염과 접촉피부염의 유발원인 및 발병기전 규명에 따라 새로운 면역조절제 개발의 기초를 확고히 하였고 기존의 스테로이드제를 대체할 수 있는 천연물 폴리페놀 소재를 이용해 항아토피,항아토피 천연물 신약후보물질의 발견, 효능탐색, 합성, 기전연구를 통해 데이터베이스 확립 및 오염 접촉형 피부질환의 효율적 관리체계를 구축하였으며, 천연물 신약개발에 따른 새로운 노하우를 축적으로 학문적기반을 구축하였음. 또한 임상시료 확보 및 분자역학 연구를 통해 아토피피부염과 접촉피부염의 새로운 진단키트를 개발하였고 이를 통해 의료비 절감 및 수입대체 효과로 국가 산업 경쟁력 강화에 기여할 것으로 봄

Abstract ▼

1.The necessity and goal of the research and development (R&D).
1-1.The goal of research and development
-The steroid agent used in medication has high possibilities of side effects in long term of use, which refers to the disease seizure mechanism.Therefore, the goal of the development is to

1.The necessity and goal of the research and development (R&D).
1-1.The goal of research and development
-The steroid agent used in medication has high possibilities of side effects in long term of use, which refers to the disease seizure mechanism.Therefore, the goal of the development is to improve the medication agent to replace the existing agent which reduces side effects.
-The designated R&D team will attempt a cellular and molecular scientific approach through discovering atopic dermatitis and contact dermatitis echanism and screening of natural compound origin candidate agent which has possibilities to grow as an international neo-agent. 1-2.The necessity of R&D
-The designated research will achieve a foundation to move into global market and reduce foreign currency consume with successful neo-medication development using natural phenol compound through domestic technique.
-A new type of medication will appear which is more specific and improved against atopic dermatitis within close future.
As considering the energetic screening research against natural compounds, it is available to develop atopic dermatitis using domestic natural compound from plants which leads to global market frontier.
2. The contents and range of R&D
-Investigate the inductive causes and seizure mechanism of atopic dermatitis and contact dermatitis
-Secure of clinical samples and molecular epidemiologic research
-Development of in-vitro and in-vivo screening model and search of candidate agents
3. Results
-The indicated study had firmly established the foundation of a new immune regulator development according to each disease seizure mechanism. Also it had established a database and build an efficient manage system of contaminative contact dermatitis through anti-atopic dermatitis agent discover, efficacy evaluation, synthesis, pathway study using natural polyphenol material which have possibilities of replacing the existing steroid agent.
4. Application plan of the study results
-The technique research of seizure mechanism study, diagnostic standardization, develops of medication agent candidates, clinical apply and commercialization through this research will be the grand plan within next decades.
-Development and register of atopic dermatitis and contact dermatitis medicating advanced natural materials establish of superior substitution system and maximize the possibilities of the candidate agents using natural polyphenol substance.