상기도감염에 대한 소청룡탕과 연교패독산의 효능: 무작위배정, 이중맹검, 위약대조군 연구 Effect of Socheongryong-tang and Yeongyopaedok-san in upper respiratory tract infection: a randomized double-blind placebo-controlled trial원문보기
보건복지가족부 Ministry for Health, Welfare and Family Affairs
등록번호
TRKO201400022445
과제고유번호
1355059613
사업명
한방치료기술개발
DB 구축일자
2019-11-16
키워드
상기도감염.소청룡탕.연교패독산.감모변증도구.Upper respiratory tract infection.Socheongryong-tang.Yeongyopaedok-san.Wisconsin Upper Respiratory Symptom Survey Korean Version(WURSS-K).Instrument of Pattern Identification for Common Cold.
초록▼
자가기입 17항목, 검사자 기입 10항목으로 구성된 감모변증 도구와 Wisconsin Upper Respiratory Symptom Survey의 한국어판 (WURSS-K)을 개발하여 내적신뢰도 (Cronbach 알파 계수 0.67～0.96), 타당도 (Pearson 상관계수 -0.267 (P<0.001))를 검증함 효능평가 임상시험에 480명이 참여하여 473명 (7명 탈락)이 분석되었고, 인구학적 분포, 변증분포, 초기 증상분포에서 세 군간 차이는 없었음 WURSS-21-K의 총 점수에 대하여 소청룡탕은 6일째 (p=
자가기입 17항목, 검사자 기입 10항목으로 구성된 감모변증 도구와 Wisconsin Upper Respiratory Symptom Survey의 한국어판 (WURSS-K)을 개발하여 내적신뢰도 (Cronbach 알파 계수 0.67～0.96), 타당도 (Pearson 상관계수 -0.267 (P<0.001))를 검증함 효능평가 임상시험에 480명이 참여하여 473명 (7명 탈락)이 분석되었고, 인구학적 분포, 변증분포, 초기 증상분포에서 세 군간 차이는 없었음 WURSS-21-K의 총 점수에 대하여 소청룡탕은 6일째 (p=0.043), 7일째 (p=0.043), 연교패독산은 5일째(p=0.049), 6일째 (p=0.043) 유의성 있게 감소시켰고, 풍한형에서 소청룡탕은 4일째부터 8일째까지(p=0.021~0.045), 연교패독산은 4일째부터 6일째까지 (p=0.013~0.021) 유의성 있게 감소시킴 증상 소실 기간에는 각 군 간에 유의한 차이는 없었고, 연교패독산은 머리가 맑지 않고 묵직함 증상을 4일째 (p=0.030), 5일째 (p=0.010) 유의하게 감소시킴 상기도감염에 대한 한방치료 EBM 자료 축적을 통해 상기도감염 한방치료 수요 증가와 새로운 한방제제 개발의 동기를 부여할 것으로 기대되며 상기도감염 항생제 사용량 감소에 간접적 기여할 것으로 기대됨
Abstract▼
Ⅲ. Results 1. Instrument of PI -PI of common cold included wind-cold pattern, wind-heat pattern, dampness pattern, summerheat pattern, qi deficiency pattern, blood deficiency pattern, yin deficiency pattern, yang deficiency pattern. CPIQ consisted of self reported 17 item and researcher report
Ⅲ. Results 1. Instrument of PI -PI of common cold included wind-cold pattern, wind-heat pattern, dampness pattern, summerheat pattern, qi deficiency pattern, blood deficiency pattern, yin deficiency pattern, yang deficiency pattern. CPIQ consisted of self reported 17 item and researcher reported 10 item. 2. WURSS-K -Correlation coefficient of frequency with original version was 0.6427(P<0.0001), correlation coefficient of severity with original version was 0.6638(P<0.0001). Cronbach alpha coefficient of internal reliability were from 0.67 to 0.96(mean 0.84), correlation coefficient with original version was 0.71. Comparing WURSS-K to SF-8 yielded Pearson corelation coefficient of -0.267(P < 0.001). Correlation coefficient of responsiveness with original version was 0.53394(P<0.0001). 3. Effects of SCRT and YPS -Four hundred eighty patients were enrolled. Group demographic distribution was comparable for clinical characteristics, distribution of PI. -SCRT significantly decreased score of WURSS-K at 6th(p=0.043) and 7th(p=0.043) day, YPS significantly decreased score of WURSS-K at 5th(p=0.049) and 6th(p=0.043) day. -In wind-cold pattern, SCRT significantly decre ased score of WURS S-K from 4th to 8th day(p=0.021~0.045), YPS significantly decreased score of WURSS-K from 4th to 6th day. -No statistically significant difference was observed between treatment groups for symptom resolution time, YPS significantly decreased head congestion at 4th(p=0.030) and 5th(p=0.010) day.
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