초록 ▼

1. Cynomolgus monkey를 이용한 급성 허혈성 뇌손상 모델 개발
❍ ICA occlusion을 인위적으로 조작하여 ischemic stroke model 개발
❍ Brain에 Streptozotocin을 투여하여 ischemic dementia model 개발
❍ 영장류 연구를 위한 관리 및 영상진단 시스템 (혈관조영, MRI) 구축

2. Cynomolgus monkey를 이용한 만성 저산소성 뇌손상 모델 개발
❍ Ballooning insertion을 통해 ischemia의 sever

1. Cynomolgus monkey를 이용한 급성 허혈성 뇌손상 모델 개발
❍ ICA occlusion을 인위적으로 조작하여 ischemic stroke model 개발
❍ Brain에 Streptozotocin을 투여하여 ischemic dementia model 개발
❍ 영장류 연구를 위한 관리 및 영상진단 시스템 (혈관조영, MRI) 구축

2. Cynomolgus monkey를 이용한 만성 저산소성 뇌손상 모델 개발
❍ Ballooning insertion을 통해 ischemia의 severity 조절 유도

3. Cynomolgus monkey를 이용한 뇌손상 치매 모델 개발
❍ Mg와 Vit. C을 결핍시킨 후 Streptozotocin을 투여하여 ischemic dementia model 개발

4. 영장류 뇌손상 평가 기술 개발 및 뇌손상 기전 규명
- 신경학적 검사를 통한 영장류 stroke evaluation 방법 확립
- MRI/A 및 Angiography를 통한 stroke evaluation 방법 확립
- MRI를 이용하여 structural change를 파악하는 dementia evaluation 방법 확립
- PET을 이용하여 metabolic change를 파악하는 dementia evaluation 방법 확립
- ICV-STZ induced dementia 영장류 모델에서 neurodegeneration에 관한 분석

Abstract ▼

We develop acute cerebral ischemia and chronic hypoxic cerebral injury models in primates, in which we investigate neuroprotective agents and molecular intervention for therapeutic application. From the primate-based research, we will study the prevention tool and pathogenesis-based treatment for hu

We develop acute cerebral ischemia and chronic hypoxic cerebral injury models in primates, in which we investigate neuroprotective agents and molecular intervention for therapeutic application. From the primate-based research, we will study the prevention tool and pathogenesis-based treatment for human diseases.

1. Development of acute cerebral injury model in primates
○ Establishment of ischemic stroke model with ICA occlusion method
○ Establishment of ICV-STZ induced dementia model
○ Establishment of management system and diagnostic imaging system for nonhuman primate research
2. Development of chronic cerebral hypoxia model in primates
○ Establishment of chroninc hypoxia model with ballooning insertion to control ischemic duration
3. Development of ischemic dementia model in primates
○ Establishment of ICV-STZ induced dementia model combined with deficiency of Mg or Vit. C
4. Development of evaluation methods for primate brain disease models and investigtaion of their neurodegenerative machanisms
○ Stroke evaluation with neurological scoring
○ Stroke evaluation with MRI, MRA and angiography
○ Dementia evaluation with PET
○ Neurodegeneration analysis of ICV-STZ induced dementia model

This study has developed disease models with primates and therapeutics for chronic hypoxic small velssel disease, which is a clinical important disease. Developed pathogenic mechanism can improve patients care and therapeutics, and have significant commercial implications for developing neuroprotective medicines in the disease. This study can result high-impact scientific papers, and patents. Further continuing studies can be linked to drug development.