초록 ▼

항산화효소인 EC-SOD는 세포외기질에 존재하면서 활성산소를 제거하는 항산화효과 뿐만 아니라 항염증효과, 새로운 혈관생성억제 효과, 종양세포증식 억제효과, 세포사멸유도효과 등이 있음을 확인하였음. 건선환자의 피부병소에서 EC-SOD의 발현이 감소한 것을 확인하였으며, EC-SOD knock out 생쥐에서는 IL-23에 의해서 유도되는 건선유사 피부염증 반응이 더욱 심하게 발생함을 확인하였음. 또한, UVB에 의한 피부염증도 EC-SOD에 의해 억제됨. UVB뿐만 아니라, EC-SOD는 hyaluronic acid fragment에

항산화효소인 EC-SOD는 세포외기질에 존재하면서 활성산소를 제거하는 항산화효과 뿐만 아니라 항염증효과, 새로운 혈관생성억제 효과, 종양세포증식 억제효과, 세포사멸유도효과 등이 있음을 확인하였음. 건선환자의 피부병소에서 EC-SOD의 발현이 감소한 것을 확인하였으며, EC-SOD knock out 생쥐에서는 IL-23에 의해서 유도되는 건선유사 피부염증 반응이 더욱 심하게 발생함을 확인하였음. 또한, UVB에 의한 피부염증도 EC-SOD에 의해 억제됨. UVB뿐만 아니라, EC-SOD는 hyaluronic acid fragment에 의해서 야기기는 피부노화를 초래하는 피부염증도 억제하였으며, Ova peptide 에 의해서 유도된 천식증상도 억제함을 검증함. 또한 체내 EC-SOD와 반응하는 여러 단백질들을 검증하였음. 따라서 상기의 결과들은 EC-SOD가 세포외기질에 존재하면서 여러 가지 자극에 의해서 유도되는 염증반응들을 억제할 수 있으며, 여러 만성질환발생을 효과적으로 치료할 수 있는 있음을 보여줌.

Abstract ▼

Extracellular matrix (ECM) has function to provide and support the environment for of cell and tissue. In response to environmental stress and infection, ECM is constantly btheien gh ormemeoosdtealesids. Trehmeo d eplriontge oaflyfetcict sc cleeallv aagdhee sainodn , fsrahgampee,n dtaiftfieorne notf

Extracellular matrix (ECM) has function to provide and support the environment for of cell and tissue. In response to environmental stress and infection, ECM is constantly btheien gh ormemeoosdtealesids. Trehmeo d eplriontge oaflyfetcict sc cleeallv aagdhee sainodn , fsrahgampee,n dtaiftfieorne notfia tsitornu,c stuurravli vcaol,m mpiognreantitosn ,d purroinligfe rtahtei opnr, oacneds se voefn tEuaClMly ctiosnsduiet ioarncsh, itiencctluurdein. gW chaennc ethr ed EevCeMlo premmeondt ealinndg pisr odgyrsersesgiounla taendd, ict hcraonn icco dntisriebaustees .t oT vhaer iopuusr ppoasteh oolof gtihciasl fporro jethcet icsh rtoon eics tsakbilnis hd istheea sbeass iacn dte icmhnmoulongey- raenlda tebda cdkigsreoausneds foofr oththee rd eovreglaonpsm. eBnat soefd colinn itchael arpepseroaarcchh feonrz ytmhee sE CanMd roetmheord eclianngd imdaetceh amnoislmec uiltesse lfo na ntdh er egEuClMati orne,m wodee lwinilgl faoncdu si momn utnhee rreoslep oonfs easn tiaonxdi dtahnet development of drugs for the future therapeutics.
The purpose of this research is
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2) aRcetsioena rmche cohna ntihsem eoffne cthtse oEfC Man taionxdi dcaonntf iremnzaytimone so fa ftfheec teinfgfe cEtCs Mo f raenmtioodxeildianngt; eSntzuydmiees oonn tthhee ERCOMS rmeimceo doefl inimg.p o3r)t aAnnt imenazly mmoedse lfso rf otrh et hEeC EMC Mre mreosdeealrinchg;, Panredp cahrartoinoinc osfk itnh ed itsreaanssegse.n ic or knock out
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5) Sthteu deieffse cotns tohfe c manedcihdaanteis mmos leocf unleesw o tna rtgheet sE CfoMr trheem oredgeulilnagti oinn mofo lEeCcuMla rr ebmioolodgeilcinagl ;a Cspoencftirsm oaft isoing noafl transduction
6) Sofc rteheeniirn ge fofef cttws oo fna ctthoer sb ainsveo lovfe ds iginn aEl CtMra srnedmuocdtieolnin g; Searching for new factors and confirmation
7) Dofe vaenltoiopxmideannt to ef nbzaysmice taencdh nnoelwog yfa cfotor rtsh eo nc oEnCtMro l roefm cohdreolninicg . s kTinh ed iasqeuaisseitsi;o nS toufd iceosr eo nb atshiec mteecchhnaonloisgmy thheraorut,g hk idtnheey r, epsuelamrochna oryn dtihsee aEsCesM a nrde mcoandceelirn. gC coamnp acroevde rw ait hw oidthee rr adnigsee aosef sd, isneoat smesa niyn csltuuddiinegs shkaivne, bhaese ne npoeurfgohr mcoemd poent ittihvee fpuonwcteiro ntaol proroled uocfe EaCcMco minp licshhrmoneinct ss.k in diseases, therefore this research
This research field can bring lots of ripple effects including,
1) promotion of ECM remodeling research activity itself currently not advanced as leading countries,
2) upgrading competitive power of pharmaceutical industry with the development of new drug,
3) iomnp rtohvee masepnetc otsf ionfd uesctorinaol mstyr,u catnudre and formation of new growth engines including training of experts
4) social and cultural advance.