초록 ▼

Ⅳ. 연구개발결과
- 시험에 적합한 방사성 동위원소표지 농약([¹⁴C]butachlor) 합성
- 호기조건 토양대사 시험 시스템 확립
호기조건 토양 대사 장치 셋업, 호기조건 토양대사 시험 SOP 작성
- 호기조건 토양대사 GLP시험 수행 및 보고서생산
- 담수(논)조건 토양대사 시험 시스템 확립
담수(논)조건 토양 대사 장치 셋업, 담수(논)조건 토양대사 시험 SOP 작성
- 담수(논)조건 토양대사 GLP시험 수행 및 보고서생산
- 식물대사 시험 시스템 확립
방사

Ⅳ. 연구개발결과
- 시험에 적합한 방사성 동위원소표지 농약([¹⁴C]butachlor) 합성
- 호기조건 토양대사 시험 시스템 확립
호기조건 토양 대사 장치 셋업, 호기조건 토양대사 시험 SOP 작성
- 호기조건 토양대사 GLP시험 수행 및 보고서생산
- 담수(논)조건 토양대사 시험 시스템 확립
담수(논)조건 토양 대사 장치 셋업, 담수(논)조건 토양대사 시험 SOP 작성
- 담수(논)조건 토양대사 GLP시험 수행 및 보고서생산
- 식물대사 시험 시스템 확립
방사성동위원소표지 농약을 이용한 식물대사 시험시설 구축, 식물대사 시험 SOP 작성
- 식물(벼)대사 GLP시험 수행 및 보고서생산
- 호기조건 토양대사 표준지침서(안) 확립
- 담수(논)조건 토양대사 표준지침서(안) 확립
- 식물대사 표준지침서(안) 확립

Abstract ▼

Soil and plant metabolism studies of pesticide are very important for predicting the degradation behavior of parent pesticides and determining the nature and extent of the metabolite, as well as for assessing the potential human, animal, and environmental hazard. Soil and plant metabolism study are

Soil and plant metabolism studies of pesticide are very important for predicting the degradation behavior of parent pesticides and determining the nature and extent of the metabolite, as well as for assessing the potential human, animal, and environmental hazard. Soil and plant metabolism study are required for the registration of new pesticide to foreign countries, such as the US EPA, EU and Japan. In case of domestic situation, metabolic method in soil and plant using labelled materials were not established. The metabolic fate of pesticides can most effectively be studied with the use of isotope. Use of radiolabelled material is to allow quantification of total, extractable and non-extractable radiolabelled residue. In addition, radiolabelled materials can be tracked easily degradation pathway.
Therefore, the establishment of guidance for soil and plant metabolism study for registration under the GLP system suitable for the registration should be essential. According to international test guideline OECD TG 307, 501, the draft test guideline for aerobic soil, aerobic paddy soil and plant metabolism were made and test system has established. And then, the case study (aerobic soil, aerobic paddy soil and rice plant metabolism) was conducted with [14C]butachlor, commonly used herbicide in Korea. From the results of case study, their potential impact on the environment can be assessed and established draft test guidelines were considered to be suitable for predicting environmental fate of pesticide in domestic.