초록

Ⅳ. 연구개발결과
○ 오키나와 소재대체 노빌레틴 고함유 품종 발굴과 감귤유래 기능성소재 발굴 및 Methyl carbonate 활용 PMF 생산방법 확인
○ 개별인정형 기능성 후보 원료 추출공정 확립과 규격설정 및 제형연구를 통한 다양한 시제품 개발
○ 인체적용 프로토콜 개발과 IRB 심의 및 인체적용시험 2건 수행
○ 개별인정형 기능성 후보원료의 단회투여/반복투여 안정성 및 유전독성평가 완료

Abstract ▼

Citrus is a genus of flowering plants in the Rutaceae family, and its fruits are important owing to their nutritional and industrial applications. The genus consists of about 1,000 species, all of which produce a characteristic and distinct flavor used in foods, perfumery, and cosmetics. According t

Citrus is a genus of flowering plants in the Rutaceae family, and its fruits are important owing to their nutritional and industrial applications. The genus consists of about 1,000 species, all of which produce a characteristic and distinct flavor used in foods, perfumery, and cosmetics. According to the Dongui Bogam, a book of traditional Korean medicine and one of the classics of oriental medicine today whose name literally means “Mirror of Eastern Medicine,” citrus fruits, in particular, have been used for the treatment of gastroenteric maladies, asthma, and loss of appetite.
Recent reports have shown that it has several medicinal functions, including anti-diabetic activity, anti-cancer activity, anti-oxidant activity, anti-tyrosinase activity, vasorelaxant effects, and anti-monoamine oxidase activity. For these reasons, there have been many reports concerning the biological activities of citrus fruits such as Citrus karna, bergamot, C. obovoidea, Fortunella japonica var. margarita, and C. natsudaidai . However, the product-specific materials of Health functional food by using Okinawa citrus Shikuwasa (C. depressa) have not yet been described.
Therefore, the aim of this project was to develop new health functional foods with C. depressa and commercialization of them. This health functional food would be helpful for reducing body fat and hyperlipidemia activity in human. In addition, this new technology may enhance both the convenience and the effectiveness of health functional food taken by healthy people and half-health or half-patient.
Ultimately, we found the functional ingredients and compounds (nobiletin) of C. depressa extract for health food standardization and examined the its reducing body fat and hyperlipidemia activity in vitro and in vivo. We established the principle that functional compound should be represented by functionality, specificity, stability, available analysis, enough amount through investigation. Therefore we can submit these results to acquire certification for functional food from KFDA.