초록

○ 내용
- 미백 기능성 화장품의 핵심 소재로서 멜라닌 생성 저해효과를 가지는 소재를 설계, 합성하고 이를 이용한 미백 화장품을 개발
- 티로시나제 활성 억제효과를 갖는 천연유래물질과 MC1R antagonist 기능을 가지는 펩타이드의 핵심서열(dipeptide)을 한분자 내에 가지는 복합미백소재

○ 특징
- 복합기작을 통해 기존 미백소재(알부틴)에 비해 미백 효능이 증대
- 펩타이드의 핵심서열을 활용한 유도체 소재 개발을 통해 소재의 안정성과 원가 문제를 극복한 소재 기술

Abstract ▼

Tyrosinase inhibitors such as arbutin or kojic acid are general whitening agents in cosmetics. These agents are useful but they have their limitations, for example low efficacy, toxicity, low solubility and so on.

Natural origin compound region having tyrosinase inhibitory activity was select

Tyrosinase inhibitors such as arbutin or kojic acid are general whitening agents in cosmetics. These agents are useful but they have their limitations, for example low efficacy, toxicity, low solubility and so on.

Natural origin compound region having tyrosinase inhibitory activity was selected such as caffeic acid, p-coumaric acid and so on. And, peptide region having MC1R antagonist activity was designed by sequences originated from Melanostatin, alpha-melanocyte stimulating hormone(α -MSH)and agouti signaling protein(ASP).

We designed small molecule conjugated peptide, and small molecule was used for capping N-terminal of the peptide. In this study, we synthesized 112 natural compounds-peptides derivatives using the solid-phase method. Among these, 4 natural compounds-peptides derivatives were registered in International Cosmetic Ingredient Dictionary (ICID). We successfully developed whitening functional cosmetics using novel whitening agent as active component.