초록 ▼

본 연구를 통하여 얻은 주요 연구개발 성과는 다음과 같다.

1. 초임계 CO2와 유기 용매(EGDMA, DEGDMA, THFA, THFMA, Methyl lactate, Ethyl lactate, Propyl lactate, 또는 Butyl lactate)를 포함하는 2성분계에서의 기액 상평형 실측

2. 초임계 CO2와 유기 용매(Dichloromethane 또는 Trichloromethane) 및 고분자(Poly(L-lactic acid), Poly(D-lactic acid), Polycaprolacton

본 연구를 통하여 얻은 주요 연구개발 성과는 다음과 같다.

1. 초임계 CO2와 유기 용매(EGDMA, DEGDMA, THFA, THFMA, Methyl lactate, Ethyl lactate, Propyl lactate, 또는 Butyl lactate)를 포함하는 2성분계에서의 기액 상평형 실측

2. 초임계 CO2와 유기 용매(Dichloromethane 또는 Trichloromethane) 및 고분자(Poly(L-lactic acid), Poly(D-lactic acid), Polycaprolactone, 또는 Poly(lactic-co-glycolic acid))를 포함하는 3성분계에서의 상평형 실측

3. 초임계 CO2를 반용매로 이용하는 ASES 공정을 통한 입자 제조
3.1 PLA stereocomplex 입자 제조
3.2 활성물질로 은 나노 입자를 포함하는 PLA stereocomplex 입자 제조
(출처 : 보고서 요약서 2P)

Abstract ▼

Ⅳ. Results
1) Binary phase equilibrium data carbon dioxide + THFA and carbon dioxide + THFMA were obtained using the phase equilibrium measuring device for high pressure. And the critical properties of THFA and THFMA were estimated with group contribution method. And the experimental data are cor

Ⅳ. Results
1) Binary phase equilibrium data carbon dioxide + THFA and carbon dioxide + THFMA were obtained using the phase equilibrium measuring device for high pressure. And the critical properties of THFA and THFMA were estimated with group contribution method. And the experimental data are correlated with Peng-Robinson equation of state.
2) Binary phase equilibrium data carbon dioxide + EGDMA and carbon dioxide + DEGDMA were obtained using the phase equilibrium measuring device for high pressure. And the critical properties of EGDMA and DEGDMA were estimated with group contribution method. And the experimental data are correlated with Peng-Robinson equation of state.
3) Binary phase equilibrium data carbon dioxide + Methyl lactate and carbon dioxide + Ethyl lactate were obtained using the phase equilibrium measuring device for high pressure. And the critical properties of Methyl lactate and Ethyl lactate were estimated with group contribution method. And the experimental data are correlated with Peng-Robinson equation of state.
4) Binary phase equilibrium data carbon dioxide + Propyl lactate and carbon dioxide + Butyl lactate were obtained using the phase equilibrium measuring device for high pressure. And the critical properties of Propyl lactate and Butyl lactate were estimated with group contribution method. And the experimental data are correlated with Peng-Robinson equation of state.
5) Ternary phase equilibrium data carbon dioxide + dichloromethane + PLLA were obtained using the phase equilibrium measuring device for high pressure. And the critical properties of PLLA were estimated by the regression of the experimental data using the simplex method algorithm. And the experimental data are correlated with hybrid equation of state combining advantages of PR-EOS and SAFT.
6) Ternary phase equilibrium data carbon dioxide + dichloromethane + PDLA were obtained using the phase equilibrium measuring device for high pressure. And the critical properties of PDLA were estimated by the regression of the experimental data using the simplex method algorithm. And the experimental data are correlated with hybrid equation of state.
7) Ternary phase equilibrium data carbon dioxide + dichloromethane + PCL were obtained using the phase equilibrium measuring device for high pressure. And the critical properties of PCL were estimated by the regression of the experimental data using the simplex method algorithm. And the experimental data are correlated with hybrid equation of state.
8) Ternary phase equilibrium data carbon dioxide + dichloromethane + PLGA were obtained using the phase equilibrium measuring device for high pressure. And the critical properties of PLGA were estimated by the regression of the experimental data using the simplex method algorithm. And the experimental data are correlated with hybrid equation of state.
9) Ternary phase equilibrium data carbon dioxide + trichloromethane + PDLA were obtained using the phase equilibrium measuring device for high pressure. And the critical properties of PDLA were estimated by the regression of the experimental data using the simplex method algorithm. And the experimental data are correlated with hybrid equation of state.
10) Ternary phase equilibrium data carbon dioxide + trichloromethane + PLLA were obtained using the phase equilibrium measuring device for high pressure. And the critical properties of PLLA were estimated by the regression of the experimental data using the simplex method algorithm. And the experimental data are correlated with hybrid equation of state.
11) Stereocomplex particles between PLLA and PDLA were obtained under various experimental conditions by ASES(Aerosol solvent extraction system) using supercritical carbon dioxide as anti-solvent. Optimal experimental condition was studied in consideration of degree of stereocomplexation and yield of preparation.
12) PLA stereocomplex particles containing silver nanoparticles for active compound were prepared by ASES using supercritical carbon dioxide as anti-solvent. By analyzing dispersity of active compound in polymer, potential of the process was estimated.
(출처 : SUMMARY 8P)

목차 Contents

• 표지 ... 1제 출 문 ... 2보고서 요약서 ... 2요 약 문 ... 4SUMMARY ... 7CONTENTS ... 10목차 ... 13제1장 연구개발과제의 개요 ... 16 1절 연구개발의 목적 및 필요성 ... 16 2절 연구개발의 내용 및 범위 ... 16제2장 국내외 기술개발 현황 ... 19제3장 연구개발수행 내용 및 결과 ... 20 1절 실험적 접근방법 ... 20 2절 이론적 접근방법 ... 23 3절 연구 내용 및 결과 ... 25 1. 초임계 이산화탄소와 Tetrahydrofurfuryl acrylate(THFA), Tetrahydrofurfuryl methacrylate(THFMA)와의 기액 상평형 측정 ... 25 2. 초임계 이산화탄소와 Ethylene glycol dimethacrylate(EGDMA), Di-ethylene glycol dimethacrylate(DEGDMA)와의 기액 상평형 측정 ... 28 3. 초임계 이산화탄소와 Methyl lactate, Ethyl lactate와의 기액 상평형 측정 ... 32 4. 초임계 이산화탄소와 Propyl lactate, Butyl lactate와의 기액 상평형 측정 ... 35 5. 초임계 이산화탄소와 Poly(L-lactic acid), Dichloromethane과의 상평형 측정 ... 38 6. 초임계 이산화탄소와 Poly(D-lactic acid), Dichloromethane과의 상평형 측정 ... 42 7. 초임계 이산화탄소와 Polycaprolactone, Dichloromethane과의 상평형 측정 ... 46 8. 초임계 이산화탄소와 Poly(lactic-co-glycolic acid), Dichloromethane과의 상평형 측정 ... 50 9. 초임계 이산화탄소와 Poly(D-lactic acid), Trichloromethane과의 상평형 측정 ... 54 10. 초임계 이산화탄소와 Poly(L-lactic acid), Trichloromethane과의 상평형 측정 ... 58 11. 초임계 이산화탄소를 반용매로 하는 ASES를 이용한 다양한 실험 조건에서의 PLLA와 PDLA의 stereocomplex 입자 제조 ... 62 12. 초임계 이산화탄소를 반용매로 하는 ASES를 이용한 활성물질로 은 나노 입자를 포합하는 PLLA와 PDLA의 stereocomplex 입자 제조 ... 82제4장 목표달성도 및 관련분야에의 기여도 ... 85 1절 연구개발목표 달성도 ... 85 2절 관련분야 기술발전에의 기여도 ... 89제5장 연구개발결과의 활용계획 ... 98 1절 자동차 소재 분야에서의 상업화 가능성 ... 98 2절 연구개발결과의 활용계획 ... 116제6장 연구개발과정에서 수집한 해외과학기술정보 ... 117제7장 연구시설ㆍ장비 현황 ... 119제8장 참고문헌 ... 121끝페이지 ... 122