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파골세포 및 조골세포를 이용하여 골 손실을 억제하는 물질을 탐색한 결과 파골세포 활성을 감소시키는 xanthohumol, 조골세포 활성을 증가시키는 paeoniflorin, actein, liquiritigenin, Achyranthes bidentata root extract를 선정함. 또한 methylglyoxal이 조골세포에 독성을 일으키는 기전을 연구하고 이를 감소시키는 sciadopitysin, liquiritigenin, paeoniflorin, apocynin, actein, deoxyactein, honokiol, g

파골세포 및 조골세포를 이용하여 골 손실을 억제하는 물질을 탐색한 결과 파골세포 활성을 감소시키는 xanthohumol, 조골세포 활성을 증가시키는 paeoniflorin, actein, liquiritigenin, Achyranthes bidentata root extract를 선정함. 또한 methylglyoxal이 조골세포에 독성을 일으키는 기전을 연구하고 이를 감소시키는 sciadopitysin, liquiritigenin, paeoniflorin, apocynin, actein, deoxyactein, honokiol, glabridin 및 luteolin의 조골세포 손상 억제 효과에 관한 논문 발표함.

○ 파골세포 기능을 억제하는 xanthohumol에 관한 연구
(1) Xanthohumol modulates the expression of osteoclast-specific genes during osteoclastogenesis in RAW264.7 cells. (Food and Chemical Toxicology 2013, 62, 99-106)

○ 조골세포 손상을 억제하는 phytochemical의 탐색 및 기전 연구
(2) Paeoniflorin isolated from Paeonia lactiflora attenuates osteoblast cytotoxicity induced by antimycin A. (Food & Function 2013, 4, 1332-1338)
(3) Effect of zinc oxide nanoparticles on the function of MC3T3-E1 osteoblastic cells. (Biological Trace Element Research 2013, 155, 287-294)
(4) Actein isolated from black cohosh promotes the function of osteoblastic MC3T3-E1 cells. (Journal of Medicinal Food 2014, 17, 414-423)
(5) Liquiritigenin restores osteoblast damage through regulating oxidative stress and mitochondrial dysfunction. (Phytotherapy Research 2014, 28, 880-886)
(6) The protective effects of Achyranthes bidentata root extract on the antimycin A induced damage of osteoblastic MC3T3-E1 cells. (Cytotechnology 2014, 66, 925-935)
(7) Pinacidil protects osteoblastic cells against antimycin A-induced oxidative damage. (Molecular Medicine Reports 2015, 11, 746-752)

○ Methylglyoxal이 유도한 조골세포의 독성을 억제하는 flavonoid를 찾아내고 관련된 기전 연구
(8) Methylglyoxal induces oxidative stress and mitochondrial dysfunction in osteoblastic MC3T3-E1 cells. (Free Radical Research 2014, 48, 206-217)
(9) Sciadopitysin alleviates methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells by enhancing glyoxalase system and mitochondrial biogenesis. (Free Radical Research 2014, 48, 729-739)
(10) Protective effect of liquiritigenin against methylglyoxal cytotoxicity in osteoblastic MC3T3-E1 cells. (Food & Function 2014, 5, 1432-1440)
(11) Inhibitory effect of paeoniflorin on methylglyoxal-mediated oxidative stress in osteoblastic MC3T3-E1 cells. (Phytomedicine 2014, 21, 1170-1177)
(12) Inhibitory effect of apocynin on methylglyoxal-mediated glycation in osteoblastic MC3T3-E1 cells. (Journal of Applied Toxicology 2015, 35, 350-357)
(13) Protective effects of honokiol against methylglyoxal-induced osteoblast damage. (Chemico-Biological Interactions 2016, 244, 169-177)
(14) Glabridin alleviates the toxic effects of methylglyoxal on osteoblastic MC3T3-E1 cells by increasing expression of the glyoxalase system and Nrf2/HO-1 signaling and protecting mitochondrial function. (Journal of Agricultural and Food Chemistry 2016, 64, 226-235)
(15) Actein protects against methylglyoxal-induced oxidative damage in osteoblastic MC3T3-E1 cells. (Journal of the Science of Food and Agriculture 2016 in press DOI 10.1002/jsfa.7713)
(16) Luteolin alleviates methylglyoxal-induced oxidative damage in osteoblastic MC3T3-E1 cells. (Cytotechnology 2016 in press DOI 10.1007/s10616-016-9977-y)
(17) Deoxyactein protects pancreatic β-cells against methylglyoxal-induced oxidative cell damage by upregulation of mitochondrial biogenesis. (International Journal of Molecular Medicine 2016, accepted)
(출처:요약문 3p)

목차 Contents

• 표지 ... 1
• 목차 ... 2
• Ⅰ. 연구결과 요약문 ... 3
• Ⅱ. 연구내용 및 결과 ... 4
• 1. 연구과제의 개요 ... 4
• 2. 국내외 기술개발 현황 ... 4
• 3. 연구수행 내용 및 결과 ... 5
• 4. 목표 달성도 및 관련 분야에의 기여도 ... 6
• 5. 연구결과의 활용계획 ... 6
• 6. 연구과정에서 수집한 해외과학기술정보 ... 6
• Ⅲ. 연구성과 ... 7
• 끝페이지 ... 9