초록 ▼

방사선 융합기술을 이용하여 고분가가치의 고성능 산업 신소재 및 의공학 신소재를 개발하여 국가 방사선 기술 산업의 선진화를 이루기 위한 과제임. 제1세부과제는 방사선을 이용한 아토피 피부염 치료용 하이드로겔 제조기술을 (주)아가방앤컴퍼니에 이전하여 상업화에 성공아였으며, 당뇨성 궤양 치료용 하이드로겔을 개발하여 기술이전 추진중. 또한 열적 안정성이 월등히 우수한 리툼 이차전지용 고분자 겔 전해질 막을 제조하여 이차전지의 안정성을 높이는데 기여하였으며 방사선을 이용하여 우수한 물성을 지닌 연료전지용 수소이온교환막 제조 기술을 개발하였음

방사선 융합기술을 이용하여 고분가가치의 고성능 산업 신소재 및 의공학 신소재를 개발하여 국가 방사선 기술 산업의 선진화를 이루기 위한 과제임. 제1세부과제는 방사선을 이용한 아토피 피부염 치료용 하이드로겔 제조기술을 (주)아가방앤컴퍼니에 이전하여 상업화에 성공아였으며, 당뇨성 궤양 치료용 하이드로겔을 개발하여 기술이전 추진중. 또한 열적 안정성이 월등히 우수한 리툼 이차전지용 고분자 겔 전해질 막을 제조하여 이차전지의 안정성을 높이는데 기여하였으며 방사선을 이용하여 우수한 물성을 지닌 연료전지용 수소이온교환막 제조 기술을 개발하였음. 제2세부는 방사선을 이용하여 에폭시, 탄소섬유강화, 탄소/탄화규소·탄소 복합체의 제조기술개발, 친환경 천연섬유제조기술개발을 통하여 하이브리드 압력용기, 고내구성 자동차후드제조 및 엔지부품 소재를 개발하여 품질 인증 획득함. 제3세부과제에서 바이오소자, 전자소자 등 미래 첨단 기술 분야에 필요한 기능성 표면처리 핵심기술을 개발하였음. 기존 기술 대비 극미량 검출, 공정 단순화를 통한 생산원가 절감 등이 가능한 독창적 기술을 개발하였으며, 향후 초고감도 바이오센서 제작 및 차세대 전자 소자 제작 분야에 크게 활용될 수 있을 것으로 판단됨.

(출처 : 보고서 요약서 5p)

Abstract ▼

IV. The result of the research and development
〇 Development of functional polyemrs by radiation
• Development of hydrogel/nanofiber/nanogel for diabetic ulcer by radiation
- In this project, new functional polymeric hydrogels were prerared for the treatment of atopic dermatitis, gel po

IV. The result of the research and development
〇 Development of functional polyemrs by radiation
• Development of hydrogel/nanofiber/nanogel for diabetic ulcer by radiation
- In this project, new functional polymeric hydrogels were prerared for the treatment of atopic dermatitis, gel polymer electrolyte and separator modification for lithium secondary battery.
- The functional hydrogels were firstly prepared by radiation technique with natural herbal extracts (NHEB-05) and it had more than 70% of atopic therapeutic efficacies. This techniques were transferred to Agabang&Company Co. Ltd. and the company had contracted to pay 550 million won of fixed royalty and 2% of annual turnover. The company launched the PUTTO for brand name in August 2009 and began selling.
- The moist retention ability of the hydrogel containing natural medicinal plants increases as more natural medicinal plants is added. The water weight was reduced faster when there was a lower concentration of honey in the hydrogels. The hydrogel dressings can supply a more moist environment for wound healing that lasts for at least 2 days at body temperature. Such dressings are pappy and non-adherent, that can reach a narrow deep opening, and also do not harm viable tissue or skin surrounding the wound. In addition, it can help absorb debris and excreta from inflamed wounds and can be cleared away easily.
- The hydrogels have an effect on inhibiting and killing the two bacteria. In particular, obvious inhibition zones appear in the againsting S. aureus and E. coli. Some research have reported that the acidic pH of honey may aid its antibacterial actions but will have a stinging effect during the therapeutic process. In our case, the hydrogel may dilute the pH of honey and give a pleasant cooling sensation, and the resulting materials will have an adequate effect on inhibiting bacteria and wound inflammation.
- The hydrogel dressings containing honey significantly stimulated the rate of healing for a surgical wound, on the contrary, the untreated control wound became infected and inflamed at days 2 to 5 (wound contraction：128.57 % to 108.49 %), accompanied with excreta and bad odor. The hydrogel dressings hastened the healing rate by accelerating wound contraction compared with wounds treated only with hydrogels. They were both curied and debrided in moist environments with less scab formation, and hydrogels with honey showed a significant acceleration of dermal repair than other trials.
- In this research, we have developed the micro-porous polyethylene membrane, which was modified by radiation grafting of methyl methacrylate in order to improve its affinity with a liquid electrolyte and thermal property. Also, we have developed the alumina filled polyethylene membrane prepared by wet process, which has a high porosity more than 60%. The mechanical strength of the membrane improved more than 30%, the thermal shrinkage decreased by 20%, as compared to the commercial membrane.

• Development of separator and polymer gel electrolyte for lithium secondary battery by radiation
- In this research, we have developed the micro-porous polyethylene membrane, which was modified by radiation grafting of methyl methacrylate in order to improve its affinity with a liquid electrolyte and thermal property. Also, we have developed the alumina filled polyethylene membrane prepared by wet process, which has a high porosity more than 60%. The mechanical strength of the membrane improved more than 30%, the thermal shrinkage decreased by 20%, as compared to the commercial membrane.

• Development of proton conductive membrane for fuel cell by radiation
- Also, we have developed the hydrocarbon-based proton exchange membranes and organic/inorganic composite fuel cell membranes by radiation. A CSPEEK membrane prepared by the addition of 30 wt% crosslinker and irradiated by EB with a dose of 200 kGy showed the optimized properties. (IEC : 1.248 meq/g, proton conductivity at room temperature: 0.083 S/cm, proton conductivity at 80 oC: 0.1234 S/cm, and dimension stability: 28%, Current density at 0.6 V: 490 mA/cm², maximum power density: 472 mW/cm²).The silane -crosslinked ETFE-g-PSSA/PTMSPM membranes with the composition of St/TMSPM(5/5, v/v) were found to show the optimized properties as a fuel cell membrane (IEC: 2.17 meq/g, tensile strength: 50 MPa, dimensional stability：38%, water uptake: 49%, proton conductivity (R.T.): 0.16 S/cm, proton conductivity (80 ℃): 0.27 S/cm, Current density: 629 mA/cm² at 0.6 V, Maximum power density:523 mW/cm²)

○ Development of advanced composite materials by radiation
- In this project, we develop the advanced composite materials such as silicon carbide fibers, carbon fiber reinforced plastics, low dielectric materials for semiconductor and adhesive technology for TFT-LCD panel by radiation.
- The developed fibers showed not only good performance with high tensile strength(2.7 GPa) and high elastic modulus(259 GPa) but also excellent thermal stability and resistant from oxygen.
- We developed an easy approach to fabricate the carbon fiber reinforced filament-wound pressure vessel and the automobile break disk by electron beam curing processing.
- The novel techniques were developed to cure as adhesive materials between the LCD panel and polyimide film by radiation. It shows 1,000 gf/cm adhesive strength within the 5 mins curing time.
- We studied novel methods to cure the low dielectric polymeric materials such as hydrogen silsesquioxane(HSQ) and polytetrafluoro-ethylene(PTFE) by electron beam techniques, respectively. These materials showed low dielectric constant with good surface hardness.
- In this project, we fabricated low density(1.5 g/cc) carbon/carbon composites with an electron beam curing technique at first. And high density(1.98 g/cc) carbon/carbon composites were fabricated by liquid silicon impregnation(LSI) technique. On the other hand we developed three kind of preforms such as needle punched, rod and weaving type to use as a carbon fiber reinforced materials.
- Natural fiber fabrication technology using a radiation was developed. As increasing the radiation dose, concentration of cellulose was increased up to 93 %. This technology suggested the novel process without the chemical process. And natural fiber reinforced plastics which polypropylene as a matrix material was fabricated. This composite showed the high mechanical properties with flextural strength 50 MPa and elastic modulus 1,980 MPa.
- Novel kind of curing technique with a radiation was developed to fabricate a carbon fiber reinforced plastic. This material showed higher mechanical properties than the other curing system. The automobile hood was fabricated by resin transfer molding process and radiation technique. This new curing system lead to reduce the processing time about 10 times. The automobile hood(8.5 kg) was very light better than conventional hood(18 kg).
- In this study, we investigated the heat resistance of thermo plastics such as PE, PP, EVA, Nylon 6, Nylon 6/6, Nylon 12, PBT and POM. The gel contents of materials can be increased as much as 20~30% with curing agents by electron beam irradiation, and also the water absorption was increased. Specially, the heat resistance of Nylon 12 was increased about 30%. The durability of abrasion of nlyon and PBT was enhanced by radiation irradiation less than 1 mg/10⁴ cycle. Finally, the application to engine part of face arm and body arm was successfully fabricated and the quality approval was obtained of these parts.
- Development of heat-resistant and durable thermoplastic elastomers and elastomers was studied such as FR, NBR, EPDM, EPDM/HDPE, EPDM/PTFE. The volume change of the elastomers can be enhanced by electron beam irradiation. And compression set of FR was reduced from 5.2% to 2.5% by electron beam irradiation. The hardness of FR, EPDM/HDPE, EPDM/PTFE was increased over than 70(shore A).

〇 Development of functional surface treatment technology by radiation
- The radiation-based techniques for the surface modification of polymer substrates for the fabrication of high performance fluorescence-based biosensors/chips and the preparation of highly-dispersible carbon nanotubes were successfully developed in this project.
The crucial techniques such as immobilization of biomolecules, prevention of biomolecules' non-specific adhesion, and the formation of biomolecule patterns were developed. On the basis of the performance evaluation results, the possibility in the fabrication of ultra-high sensitive biosensor was successfully ascertained.
The radiation based cutting and surface functionalization of carbon nanotubes were developed to prepare highly-dispersible carbon nanotubes.
- The radiation-induced core techniques for the out-of-state fields such as organic electronics, biosensors, and so on were developed in this project.
The fabrication techniques of ink-jet printing conductive carbon nanotubes with a dispersiblity of 2 wt% were developed. Using an inkjet printing system, the possibility in the application of the prepared ink was estimated through the fabrication of OLED devices and mcirofluidic chips.
The surface modification techniques were developed to improve the adhesion strength between polymer and metal up to more than 2 N/cm, which will be useful in the fabrication of flexible electrodes such as FPCB.
The core techniques for the fabrication of label free silicon nanowire-based nanobiosensors with a ultrahigh sensitivity were developed.

(출처 : SUMMARY 20p)

목차 Contents

• 표지 ... 1
• 방사선 융합 유기 신재료 기술 개발 (Development of new organic materials by radiation) ... 1
• 제 출 문 ... 2
• 보고요약서 ... 5
• 요 약 문 ... 6
• SUMMARY ... 17
• CONTENTS ... 28
• 목차 ... 30
• 제1장 연구개발과제의 개요 ... 32
• 제1절 연구개발의 필요성 ... 32
• 제2절 연구개발의 목적 및 범위 ... 35
• 1. 연구개발 최종목표 ... 35
• 2. 연구개발의 범위 ... 36
• 제2장 국내외 기술개발 현황 ... 42
• 제1절 선진국 연구개발 동향 및 기술수준 ... 42
• 제2절 국내 연구개발 동향 및 선진국과의 기술격차 ... 48
• 제3장 연구개발수행 내용 및 결과 ... 52
• 제1절 방사선 이용 기능성 고분자 개발 ... 52
• 제2절 방사선 이용 복합 신소재 개발 ... 59
• 제3절 방사선 이용 기능성 표면처리 기술 개발 ... 69
• 제4장 목표달성도 및 관련분야에의 기여도 ... 82
• 제1절 목표달성도 ... 82
• 1. 1차년도 연구목표 ... 82
• 2. 2차년도 연구목표 ... 83
• 3. 3차년도 연구목표 ... 86
• 4. 4차년도 연구목표 ... 89
• 5. 5차년도 연구목표 ... 93
• 제2절 관련분야에서의 기여도 ... 97
• 제5장 연구개발결과의 활용계획 ... 100
• 제6장 연구개발과제에서 수집한 해외과학기술정보 ... 103
• 제7장 연구시설·장비현황 ... 108
• 제8장 참고문헌 ... 109
• 방사선 이용 기능성 고분자 개발 (Development of functional polymers by radiation) ... 116
• 제 출 문 ... 117
• 보고요약서 ... 119
• 요 약 문 ... 120
• SUMMARY ... 134
• CONTENTS ... 154
• 목차 ... 156
• 제1장 연구개발과제의 개요 ... 158
• 제1절 연구개발의 필요성 ... 158
• 제2절 연구개발의 목적 및 범위 ... 165
• 1. 연구개발 최종목표 ... 165
• 2. 연구개발의 범위 ... 165
• 제2장 국내외 기술개발 현황 ... 168
• 제1절 선진국 연구개발 동향 및 기술수준 ... 168
• 1. 아토피용 수화겔 제조기술 개발 ... 168
• 2. 궤양치료용 수화겔 제조기술 개발 ... 168
• 3. 리튬 이차전지용 분리막 및 고분자 겔 제조기술 개발 ... 169
• 4. 연료전지용 수소이온 전도성막 제조기술 ... 169
• 제2절 국내 연구개발 동향 및 선진국과의 기술격차 ... 169
• 1. 아토피용 수화겔 제조기술 ... 169
• 2. 궤양치료용 수화겔 제조기술 개발 ... 170
• 3. 리튬 이차전지용 분리막 및 고분자 겔 제조기술 ... 171
• 4. 연료전지용 수소이온 전도성막 제조기술 ... 171
• 제3장 연구개발수행 내용 및 결과 ... 173
• 제1절 방사선 이용 아토피 피부염 치료용 하이드로겔 제조 기술 개발 ... 173
• 1. 아토피 치료 효과 우수 천연소재 선별 및 효능평가 ... 173
• 2. 아토피 치료용 하이드로겔 합성기술 ... 203
• 3. 아토피 치료용 하이드로겔 동물/임상 실험 ... 214
• 제2절 방사선 이용 궤양 치료용 하이드로겔 제조 기술 개발 ... 241
• 1. 천연물 함유 당뇨성 궤양 치료용 하이드로겔 제조 기술 개발 ... 241
• 2. 천연물 함유 궤양 치료용 겔 페이스트제 제조 기술 개발 ... 265
• 3. 궤양 치료용 약물전달 하이드로겔 제조 기술 개발 ... 273
• 4. 궤양 치료용 천연고분자 섬유 제조 기술 개발 ... 319
• 5. 방사선 이용 궤양 치료용 마이크로 캡슐 제조 기술 개발 ... 327
• 6. 궤양 치료용 하이드로겔의 동물실험에 의한 효능평가 ... 340
• 제3절 방사선 이용 리튬 이차전지용 분리막 및 고분자 겔 제조기술 개발 ... 365
• 1. 방사선을 이용한 리튬이차전지용 고분자 겔 전해질 개발 ... 365
• 2. 방사선을 이용한 이차전지용 다공성 그라프트 고분자 분리막 개발 ... 394
• 3. 방사선을 이용한 이차전지용 다공성 폴리에틸렌 고분자 분리막 개발 ... 428
• 4. 방사선을 이용한 리튬이차전지용 다공성 유/무기 복합막 제조 기술 개발 ... 445
• 제4절 방사선이용 탄화수소계 및 유/무기복합 연료전지막 제조 기술 개발 ... 478
• 1. 탄화 수소계 연료전지용 수소 이온 전도성막 제조 기술 개발 ... 478
• 2. 방사선을 이용한 유/무기 복합 연료전지막 제조기술 개발 ... 512
• 제4장 목표달성도 및 관련분야에의 기여도 ... 566
• 제1절 목표달성도 ... 566
• 1. 1차년도 연구목표 ... 566
• 2. 2차년도 연구목표 ... 567
• 3. 3차년도 연구목표 ... 568
• 4. 4차년도 연구목표 ... 569
• 5. 5차년도 연구목표 ... 570
• 제2절 관련분야에서의 기여도 ... 572
• 제5장 연구개발결과의 활용계획 ... 574
• 제6장 연구개발과제에서 수집한 해외과학기술정보 ... 577
• 제7장 참고문헌 ... 579
• 끝페이지 ... 582