초록

○ 매식치와 관련된 구강환경변화의 원인을 구명(究明)하고, 기능저하 및 손상을 해결할 수 있는 환경제어용 기능성 매식치를 개발하는데 최종목표가 있음.
○ 본 과제의 성공적 목표달성을 위하여 기능성 매식치 개발을 위한 재료학적 접근을 기반으로 미생물학적, 분자생화학적, 독성학적 연구를 체계적/통합적으로 수행함으로써 차세대 환경제어용 기능성 매식치 개발을 선도하고자 함.

( 출처 : 보고서 요약서 3p )

Abstract ▼

Purpose
● The purpose of this study is to develop oral environment-regulating functional implant by identifying the causes of its related physiological changes
● This study focuses on the development of new generational implant through systemic approaches on dental material, microbiology, bioc

Purpose
● The purpose of this study is to develop oral environment-regulating functional implant by identifying the causes of its related physiological changes
● This study focuses on the development of new generational implant through systemic approaches on dental material, microbiology, biochemistry and toxicology

contents
1) First stage (2014-2016)
● Basic research on implant-related oral environmental changes
● Basic research on the functional implants regulating oral environment
● Optimization of functional implants and mechanistic study
2) Second stage (2017-2018)
● Optimization of implant-applicable functional materials and establishment of animal model
● The research on the combinational efficiency of functional implants and its safety

Developement results
● Study of functional implant by surface modification for regulating the oral environment
- It was confirmed that thermal oxidation films formed at 650 ℃ or higher temperature had higher stability and bioactivity by the study on the heat treatment of Ti–15Mo alloy for increasing the bioactivity of implant.
- It was identified that complex treatment using alkali and acid solutions effectively contributed to the bioactivity by the study on the surface modification of Ti for ensuring long-term bond strength.
● Development of anti-cariogenic and anti-perocoronitis target on implants through studying on the virulences of biofilms
- Identification of plant components that can inhibit acid production, proton permeability, and F-ATPase activity of biofilms.
- Establishment of the mechanisms related to biofilm virulence factor inhibition, especially gene secretion.
- Inhibition effects of the identified components on extra-cellular polysaccharides and composition of biofilms in confocal laser scanning microscopic study.
- Selection of anti-cariogenic and anti-perocoronitis target.
● Evaluation of bone regeneration materials (include genes) on titanium surface or implants
- Identification of functional characters (PPARγ, IGFBP-3, c-myb) which has bone growth, anti-inflammation and biocompatibility against alveolar bone.
- Establishment of bone growth compounds such as sodiun acetyl cysteine, Terrein, Davallialactone which has to increase bone biocompatibility on titanium surface to osteoblast cells.
● Identification of the role of receptor-interacting protein (RIP2), an adaptor molecule of NOD1/2 receptor in the periodontitis
- Identification of the effects of RIP2 on the production of IL-6 and TNF-α in toll- like receptor-deficient macrophages.
- Confirmation of MAPK activation in F. nucleatum–infected macrophages and nitric oxide production against F. nucleatum infection.

Expected Contribution
● Enforcement of BT industries-related national competitiveness by establishing a basic research on next-generation functional implants
● Contribution to the oral hygiene and quality of life through extended application of the implants for aged people or chronic patients
● Expansion of medical instrument market scale to 40 billion dollar-scale market and the entry of “bone-anchored implant” called field related to plastic surgery, ENT and etc.

( 출처 : SUMMARY 5p )

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 요 약 문 ... 4
• SUMMARY ... 5
• 목차 ... 6
• 1. 연구개발 목표 및 내용 ... 7
• 가. 최종 목표 ... 7
• 나. 단계목표 ... 7
• 다. 당초 목표의 수정·보완(중요 연구변경) 사유 ... 8
• 라. 1단계 연차별 연구목표 및 내용 ... 8
• 2. 연구 추진전략 및 방법 ... 8
• 가. 연구 추진전략 ... 8
• 나. 연도별 연구 추진 일정 ... 10
• 3. 주요 연구개발 결과 ... 12
• 가. 목표달성도 ... 12
• 나. 대표적 연구업적 ... 57
• 다. 기타 연구성과 ... 58
• 4. 연구수행에 따른 문제점 및 개선방향 ... 58
• 5. 연구개발성과 현황 ... 58
• 6. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 79
• 7. 기타사항 ... 79
• 끝페이지 ... 80