Abstract ▼

Purpose& contents
Aim to investigate brain responses to endogenous pain (experimental pain) in chronic pain patients and pain modulatory mechanism of acupuncture
1) investigate neurophysiological mechanism of acupuncture analgesic effect using neuroimaging
2) evaluate analgesic effect of ac

Purpose& contents
Aim to investigate brain responses to endogenous pain (experimental pain) in chronic pain patients and pain modulatory mechanism of acupuncture
1) investigate neurophysiological mechanism of acupuncture analgesic effect using neuroimaging
2) evaluate analgesic effect of acupuncture using a novel placebo acupuncture (phantom acupuncture)
3) suggest objective indices to evaluate acupuncture effect on hyperalgesia in LBP
4) integrate brain imaging, peripheral autonomic responses, QST and investigate direct links between central response and clinical outcomes

Result
1. Development of video-guided phantom acupuncture (placebo) system
· sham acupuncture without somatosensory stimulation was suggested by using videoclip to keep expectancy of acupuncture
2. Design of endogenous pain model mimicking clinical symptoms of low back pain
3. Suggestion of the objective indices to evaluate hyperalgesia in low back pain patients
· pain specific Quantitative Sensory Test and clinical questionnaires
4. Clinical trial in low back pain
· MRI and QST sessions were completed from 23 subjects for phantom acupuncture and 26 subjects for verum acupuncture
5. Autonomic responses to acupuncture
· the visual information, somatosensory sensation, and expectancy of acupuncture were defined as acupuncture effective components
· autonomic timecourse was segmented to the three components as described above
· acupoint specific effect was also analyzed by autonomic responses to each acupoints
5. Pain modulatory mechanism in low back pain patients
· there were increased brain responses in secondary somatosensory cortex and anterior insula where are known as pain processing areas in both verum and phantom acupuncture groups
· phantom acupuncture stimuli did not induce brain activations in primary somatosensory cortex, posterior insula whereas increased brain responses in the areas were found in verum group
· compared with verum acupuncture, phantom acupuncture increased bilateral inferior frontal gyrus(IFG), dorsolateral prefrontal gyrus(DLPFC) suggesting placebo effects are mainly controlled by mirror networks and higher cognitive function
· Default mode network connectivity to IFG and insula (middle and posterior part)were increased after the acupuncture treatment, and DMN to IFG and pINS connectivity were associated with changes in clinical pain

Expected Contribution
1. Experimental pain model mimicking clinical pain ould provide better understanding of the central mechanism in LBP
2. A novel sham acupuncture could be used in clinical trials with different diseases to investigate placebo effect of acupuncture
3. neurophysiological mechanism using neuroimaging and autonomic data could provide better understanding of placebo and acupuncture specific effect of analgesia
4. research infra for a multidisciplinary study in Korea medicine and brain science (brain engineering)

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 목차 ... 2
• 연구계획 요약문 ... 3
• 연구결과 요약문 ... 4
• 한글요약문 ... 4
• SUMMARY ... 5
• 연구내용 및 결과 ... 6
• 1. 연구개발과제의 개요 ... 6
• 2. 국내외 기술개발 현황 ... 8
• 3. 연구수행 내용 및 결과 ... 9
• 4. 목표달성도 및 관련분야에의 기여도 ... 20
• 5. 연구결과의 활용계획 ... 21
• 6. 연구과정에서 수집한 해외 과학기술정보 ... 22
• 7. 참고문헌 ... 23
• 8. 연구성과 ... 24
• 9. 국가과학기술지식정보서비스에 등록한 연구시설‧장비 현황 ... 25
• 10. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 25
• 11. 기타사항 ... 25
• 끝페이지 ... 25