초록 ▼

[공동연구내용]
▪ 적응형 방사선치료 (Adaptive radiation therapy) 기반 환자 맞춤형 방사선치료 기술 개발
· 변형 가능 정합 기반 적응 방사선 치료 기술 개발
· 적응 방사선 치료 계획 최적화 기술 및 임상 응용 기술 개발
▪ 영상유도 방사선치료 (Image guided radiation therapy) 기반 4D 방사선치료 기술 개발
· 4D target localization 기술 개발
· 4D 선량 검증 기술 개발
▪ 다중 영상 기반 생물학적 방사선치료 (Biolog

[공동연구내용]
▪ 적응형 방사선치료 (Adaptive radiation therapy) 기반 환자 맞춤형 방사선치료 기술 개발
· 변형 가능 정합 기반 적응 방사선 치료 기술 개발
· 적응 방사선 치료 계획 최적화 기술 및 임상 응용 기술 개발
▪ 영상유도 방사선치료 (Image guided radiation therapy) 기반 4D 방사선치료 기술 개발
· 4D target localization 기술 개발
· 4D 선량 검증 기술 개발
▪ 다중 영상 기반 생물학적 방사선치료 (Biological radiation therapy) 기술 개발
· 다중 영상을 이용한 생물학적 치료 기술 개발
· 생물학적 치료 계획 평가 및 최적화 기술 개발

[기관 유치 및 운영]
▪ 미국 Stanford University 내 분자영상연구소(Molecular Imaging Program at Stanford, MIPS) 및 방사선종양학과 의학물리 연구팀과 공동 연구체제를 구축함.
▪ 핵심인력 교환을 통해 선진 기술을 확보하고, 연구소 연구 환경 개선, 공동 연구 장비 유치 등을 통하여 Stanford 대학의 세계적인 연구 인프라를 가톨릭대학교 생체의공학연구소에 유치하여 의학 물리를 선도하는 세계적인 기술 수준을 보유한 연구센터를 건립함.
▪ 양 기관에 공동 연구 공간 및 연구 인프라를 확보하고, 협정에 의거, 공동 논문발표, 특허, 기술이전, 기술지도 등을 통한 공동 연구업적을 수행함.

( 출처 : 보고서 요약서 3p )

Abstract ▼

Ⅱ. Research and Development
1. The objectives and necessity of the project
A. Necessity of the project
(1). Technical aspects
(A) Newly advanced medical image technology
(B) Research cooperation for the rapid growth of advanced radiation therapy technology
(C) Improvement of applic

Ⅱ. Research and Development
1. The objectives and necessity of the project
A. Necessity of the project
(1). Technical aspects
(A) Newly advanced medical image technology
(B) Research cooperation for the rapid growth of advanced radiation therapy technology
(C) Improvement of application technique using advanced radiation therapy technology
(D) Self- image technology of domestic cell level molecular imaging
(E) Attract research cooperation framework for global treatment technical skills
(F) Advanced technology introduction and domestic self-treatment technique

(2) Economical and industrial aspect
(A) Growth of radiation industry scale according to cancer patient accrual
(B) Highly marketable diagnosis-therapy fusion technology
(C) Development of new medical equipment for advanced molecular imaging
(D) Diverse development of industry through Various fused expertise

(3). Social and Cultural aspect
(A) Increase of radiation therapy importance by growth of cancer patients
(B) Promotion of welfare benefaction due to improvement of cancer treatment medical technique level
(C) Improvement of medical service level through development and propagation of advanced cancer diagnosis and treatment technique

B. Objectives of the project
(1) Final objective: Accomplish domestic medial technique independence and build Mecca of global superior research by developing medical physics technique for cancer treatment through institute operation and research cooperation with international superior research center researchers who have global competitive power.
(2) Objectives of detailed research
(A) Development of adaptive radiation therapy technique
(B) Development of image guided radiation therapy technique
(C) Development of biological radiation therapy technique

2. Research and development contents and scope
A. Research contents and scope
(1) Development of adaptive radiation therapy technique
(A) Characteristic of kV/MV CBCT images depend on the treatment positions
(B) Development of CBCT　image quality improvement technique　（Improvement of noise and contrast)
(C) Development the optimization of 3D image registration technique in individual therapy
(D) Development of deformable image registration for fractionated treatment
(E) Development the auto-contouring mapping technique of CBCT image based deformable image registration
(F) Development of dose distribution model based CBCT images
(G) Development of dose distribution model for advanced flattening filter free (FFF) radiation treatment devices
(H) Development of advanced FFF beam spectrum induced technique
(I) Development of IMRT dose distribution optinization technique using advanced FFF beam
(J) Development of beam aperture based Rapid Arc beam optimization technique
(K) Developement of clouding computing based rapid dose calculation
(L) Development of clouding computing based rapid dose distribution optimization decision technique

(2) Development of image guided radiation therapy based 4D radiation treatment technique
(A) Clinical data acquisition of 4D organ motion
(B) Technique the simulation of 4D organs moving
(C) Development of 4D CT motion artifact analysis technique
(D) Development of respiration signal technique for 4D CT image optimization
(E) Development of 4D target localization method
(F) Estimation degree of 4D target localization accuracy
(3) Development of Multi-modality image based biological radiation therapy
(A) Functional image analyzation in clinical case
(B) Extraction biological factor by functional image
(C) Development of image fusion technique between functional image and anatomical image
(D) Analysis the correlation between functional image and biological factors
(E) Mapping technique Development between image of biological factors
(F) Development of area segmentation technique in tumor using biological factors
(G) Development of tumor tracking technique using advanced cancer diagnosis devices
(H) Development of visibility and incoming technology of treatment planning system in advanced cancer diagnosis devices
(I) Technical development of tumor volume control using advanced cancer diagnosis image
(J) Development of advanced cancer diagnosis image based treatment planning evaluation technique
(K) Development GUI environment for advanced cancer diagnosis image input and analysis
(L) Completion of advanced cancer diagnosis image based biological treatment integrated software

B. Division of role with Joint Research Center
(1) Major role of domestic research center
(A) Initiate treatment planning application technology, dose optimization and calculation technology, and joint research equipment and facilities exchange
(B) Share facilities and various treatment devices
(C) Share engine and dose calculation system
(D) Share molecular image based treatment planning technique
(E) Share developed spectrum modeling code and advanced adaptive radiation treatment device (TrueBeam linear accelerator) beam modeling

(2) Major role of offshore research center
(A) Initiate advanced radiation treatment technology, molecular image technology, and joint research equipment and facilities exchange
(B) Share animal experiment facilities and molecular imaging system, initiate optimization and quantitative analysis technology, and acquisite molecular imaging
(C) Share and develop various molecular imaging devices, bio-markers, molecular biology
(D) Share advanced radiation treatment devices
(E) Clinical data acquisition for application and verification of clinical, pre-clinical level for adaptive radiation dose calculation code

3. Outcomes of research development
(1) Adaptive radiation treatment based patient specific radiation treatment technique development (Achievement: 100%)
(A) Development of CBCT image optimization technique
(B) Development of deformable image registration for fractionated treatment
(C) Technology development basis on fused image based image division and mapping technique
(D) Development of dose distribution modeling and spectrum induced technique for FFF beam treatment
(E) Development of IMRT dose distribution and Rapid Arc beam optimization techique using FFF beam
(F) Development of clouding computing based rapid dose distribution optimization decision technique

(2) Development of image guided radiation treatment based 4D radiation treatment technique (Achievement: 100%)
(A) Clinical data acquisition of 4D organ motion
(B) Technique the simulation of 4D organs moving
(C) Development of 4D CT motion artifact analysis technique
(D) Development of respiration signal technique for 4D CT image optimization
(E) Development of 4D target localization method
(F) Estimation degree of 4D target localization accuracy

(3) Development of Multi-modality image based biological radiation therapy(Achievement: 100%)
(A) Development of functional image analysis module
(B) Development of biological factor analysis technique using functional image
(C) Development of tumor volume decision and mapping technique using biological factors of multi-modality image
(D) Development of visibility technology of treatment planning system and tumor tracking technology basis on advanced cancer diagnosis image
(E) Development of advanced cancer diagnosis image based tumor volume decision technology and radiation treatment planning evaluation technology
(F) Completion of advanced cancer diagnosis image based biological treatment integrated software and Development GUI environment for advanced cancer diagnosis image based input and analysis

4. Application Plan of Research development outcome
A. Expectation and ripple effect
(1) Clinical application evaluation and research presentation trhough IMRT dose analysis using FFF beam
(2) Combination of radiation treatment with clouding technique
(3) Plan advance of domestic radiation treatment technique level using advantages of clouding system
(4) Improvement of therapeutic efficiency and securement accuracy of radiation treatment according to artifact reduction by more accurate image fused technology
(5) Securement of clinical utility and radiation treatment efficiency improvement through multi-functional image method

B. Commercialization and application plan
(1) Research exchange and study presentation about application method of molecular image and radiation treatment fused technology
(2) Promotion technology transfer after clinical adaptation assessment of tumor tracking technique through domestic and foreign hospital and research institute
(3) Promotion technology transfer after algorithm verification and development through domestic and foreign hospital and research institute
(4) Combination of cell treatment technique, immunotherapy, and molecular image based radiation treatment
(5) Examination of integrated analysis software commercialization through multi molecular image fused technique
(6) Medical software technical commercialization with various treatment module and molecular image application
(7) Merchandise through strategic alliance with domestic and foreign industries

Ⅲ. Recruited institute management
1. The necessity and purpose of recruiting global research institute
A. The purpose of recruiting global research institute
(1) Development of advanced medical physics techniques from worldwide research network and outstanding workforce
(2) Development of diagnosis and treatment techniques of cancer from introduction of advanced technology
(3) Recruiting global research institute through cooperation with domestic and foreign research institute and organic school-work links
(4) Independent of domestic medical physics and improvement in standards of medical health care

B. The superiority of global research institute
(1) World best research institute in molecular image and fused medical division
(2) Lead world research trend in cancer diagnosis·treatment division
(3) Possession of comprehensive image system facility for molecular image
(4) Organized professional researches in each necessary field for developing molecular image technique
(5) Self-development of various clinical adaptation image system
(6) Broad-based industry-academic infrastructure for development of cancer diagnosis·treatment technique

C. The necessity of recruiting global research institute
(1) Technical aspects
(A) Application of research infra and outstanding workforce in Stanford university
(B) Application of self-developed advanced technology from Stanford university
(C) Promotion of development in future-oriented diagnosis and treatment techniques
(D) Development of advanced medical technology through clinical adaptation technique
(E) Application of domestic radiation medical science field technique

(2) Economical and industrial aspect
(A) Benchmark the industry-academic based commercial model
(B) Commercialization of research outcome through advanced technologies acquisition
(C) Arrangement of bridgehead for value-added medical device industry's chances to advanced the offshore market

2. Cooperation performance with offshore research institute
A. Securing budget and detail statement
(1) Cost of foreign institution: foreign partner resource statement for each year

B. Resource management performance
(1) Holding symposium and seminar

(2) Domestic and foreign human power exchange
(A) Visit of excellent researcher from Stanford University and attracting the long-term and short-term
(B) Long-term and short-term dispatch of Catholic University researcher

(3) Sharing the equipment and knowledge with foreign research group
(A) Joint research with Stanford University and sharing the development technology/knowledge
(B) Sharing the state-of-the-art technology and equipment of Stanford University

(4) Technical consultation for core research technology development
(A) Adaptive radiation therapy
(B) 4D image-guided radiation therapy
(C) Biological radiation therapy

3. Effort and outcome of attracting offshore research institution
A. Effort of attracting offshore research institution
(1) Build domestic and foreign research cooperative system
(A) Maintain research collaboration with Stanford University
(B) Maintain research collaboration with related domestic and foreign research institutions
(C) Promotion technology exchange with related domestic and foreign research institutions
(D) The domestic and foreign medical physics conference based academic Activity link

(2) Public communication of joint research center
(A) Reserve joint research center promotion space during domestic and foreign conference
(B) Hold symposium with a Nobel prize laureate for Global R&D Center industry based proposals for revitalizing the creative economy
(C) Hold theNational Assembly forum for success of creative economy

(3) Management of excellent human resources

B. Attracting performance of offshore superior research institution
(1) Development of adaptive and biological radiation treatment technique
(A) Suggest and develop the solution for rapid calculation, optimization model, dose calculation for real-time adaptive radiation treatment
(B) Development of integrated software which is available to do biological treatment plan through clinical adaptive technique and cancer cell detection using advanced cancer diagnosis image

(2) Present condition of investment
(A) The Catholic University, The Industrial-Academic Cooperation Group
(B) Offshore institute (Stanford University) matching fund

C. Representative Results
(1) Selected in "Outstanding Contributions Over the Last 50 years" in International Organization for Medical Physics (IOMP) Jubilee Awards
(2) Suggested technical skills based creative economy model

4. Application plan and self-supporting of joint research center
A. The plans to establish the self-supporting research center
(1) Promoting of independent incorporation
(A) Construction of infrastructure and product planning through research project
(B) Promoting re-investment in research technique development of company through technology transfer and assistance
(C) Preparing independence corporate through related follow-up project and profit from commercialization and consulting
(D) Role performance of exchange forum of domestic and foreign industry-academic institutions

(2) Promote self-supporting et cetera research institution
(A) Development of related software and device
(B) Development technology transfer
(C) Professional consulting from domestic hospital and related companies
(D) Consulting from web-based foreign hospital and related research institutes

(3) Application of domestic and foreign excellent human resources

B. Plan of advancing center's heavy equipment
(1) Production line construction of domestic company based on technology transfer with our center
(2) Take-off foreign onsite project which linked with domestic company

C. Application plan of joint research center
(1) Exchange forum of domestic and foreign industry-academic institutions in various fields
(2) Bridgehead of advancing asia market
(3) Targeting medical market linked with domestic company
(4) Joint development of the world market

( 출처 : SUMMARY 10p )

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 요 약 문 ... 4
• S U M M A R Y ... 10
• C O N T E N T S ... 18
• 목차 ... 19
• 제 1 장 연 구 개 발 ... 20
• 제 1 절 : 연구개발의 목적 및 필요성 ... 20
• 제 2 절 : 국내·외 기술개발 현황 ... 25
• 제 3 절 : 연구개발 내용 및 결과 ... 30
• 제 4 절 : 연구개발 목표달성도 및 관련분야에서의 기여도 ... 214
• 제 5 절 : 연구개발결과의 활용 계획 ... 220
• 제 2 장 기관유치 및 운영 ... 224
• 제 1 절 : 해외연구기관 유치 목적 및 필요성 ... 224
• 제 2 절 : 공동연구센터 운영 현황 ... 232
• 제 3 절 : 해외연구기관의 협력 성과 ... 245
• 제 4 절 : 해외연구기관 유치 노력 및 성과 ... 322
• 제 5 절 : 공동연구센터 자립 및 활용계획 ... 334
• 제 3 장 기타 사항 ... 339
• 제 1 절 : 사업추진과정에서 수집한 해외과학기술정보 ... 339
• 제 2 절 : 연구시설‧장비 현황 ... 351
• 제 3 절 : 기타 사업성과 ... 355
• 제 4 절 : 참고문헌 ... 360
• 붙임 1 해외우수연구기관유치사업 연차별 목표 및 달성도 현황 ... 365
• 붙임 2 해외우수연구기관유치사업 예산 확보 및 사용 실적 ... 374
• 붙임 3 해외우수연구기관유치사업 대표 성과 및 연구성과 보고서 ... 382
• 끝페이지 ... 485