Abstract ▼

1. The mass spectrometry endoscopy system was developed by analyzing the microscope-based ambient mass spectrometer developed for the endoscopic development of the mass spectrometer.
Modularization of the fiber laser, the ionization source and the gas flow particle transfer device and the basic d

1. The mass spectrometry endoscopy system was developed by analyzing the microscope-based ambient mass spectrometer developed for the endoscopic development of the mass spectrometer.
Modularization of the fiber laser, the ionization source and the gas flow particle transfer device and the basic design of the system was achieved and confirmed. The laser uses a visible light continuous laser which is capable of applying optical fiber. The mass spectrometry is tested on animal model, also it is attached to a fiber laser, and the ionizer is installed at the entrance of the mass analyzer.

2. To obtain good spatial resolution of the mass spectrometric imaging obtained with this equipment, a resolution test specimen with a rat hippocampal tissue and a grid (400 mesh size) was made. The x-axis resolution was measured as about 3 μm and 5 μm when the moving speed of the sample was 10 μm/s and 30 μm/s.

3. A spectral domain optical coherent tomography system was constructed and a cross section imaging of human nail could be achieved. Then, the endoscopic system was constructed by attaching a fiber bundle with a GRIN lens at the sample arm. In addition, a swept source optical coherence tomography system have been developed. It is possible to acquire real-time 3D images through two GPUs and will be incorporated into this endoscopic system.

4. In order to show the difference between normal and cancerous region on bio-tissue, an excised porcine stomach stained with a fluorescent dye was used as a phantom. It was confirmed that the tumor region and the normal region can be distinguished by the developed multispectral endoscope.

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 초록 ... 3
• 요 약 문 ... 4
• S U M M A R Y ... 5
• C O N T E N T S ... 6
• 목차 ... 7
• 제 1 장 연구개발과제의 개요 ... 8
• 1. 연구개발 목적 및 필요성 ... 8
• 2. 연구개발 범위 ... 9
• 제 2 장 국내외 기술개발 현황 ... 10
• 1. 국내외 기술개발 현황 ... 10
• 2. 현보유 기술대비 국내외 기술개발 현황 비교 ... 11
• 제 3 장 연구개발수행 내용 및 결과 ... 13
• 1. 연구개발 수행 내용 ... 13
• 2. 연구결과 ... 19
• 3. 대표연구실적 사례 ... 29
• 제 4 장 목표달성도 및 관련분야에의 기여도 ... 29
• 1. 목표 달성도 ... 29
• (1) 정성적 목표 달성도 ... 29
• (2) 정량적 목표 달성도 ... 30
• 2. 관련분야에의 기여도 ... 33
• 제 5 장 연구개발결과의 활용계획 ... 35
• 1. 성과활용방향 ... 35
• 2. 성과활용 차수별 활용계획 ... 36
• 제 6 장 연구개발과정에서 수집한 해외과학기술정보 ... 36
• 1. 대기압 질량분석 기술 및 질량분석 기반 기술의 응용 ... 36
• 2. 대기압 질량분석의 해외 과학 기술 동향과 본 연구에서 확보한 기술의 중요성 ... 37
• 3. 국외 OCT 기반 내시경 개발의 현황 ... 38
• 제 7 장 참고문헌 ... 41
• 끝페이지 ... 43