초록 ▼

2013년부터 2017년까지 진행된 경혈자극의 말초-척수-뇌 신호전달 체계 규명 과제에서는 경혈경락의 조직학적 특성 및 전기생리학적 기능 연구를 통하여 실체 확인과 신호전달체계를 규명하고자 함

경혈의 형태학적 특성 확인에서는 이종 동물 간 프리모 조직의 조직학적 특성과 동질성을 확보하여 감별기준을 확립함. 장부경락 상관성 확인에서는 위장관 동물모델에서 체표반응점의 침자극 효과가 DRG 내 신경경로를 통하고, 대장-반응점 공통신경의 척수내 경로를 관찰함. 경혈자극의 작용기전 확인에서는 알코올 중독 동물모델에서 경혈 자극이

2013년부터 2017년까지 진행된 경혈자극의 말초-척수-뇌 신호전달 체계 규명 과제에서는 경혈경락의 조직학적 특성 및 전기생리학적 기능 연구를 통하여 실체 확인과 신호전달체계를 규명하고자 함

경혈의 형태학적 특성 확인에서는 이종 동물 간 프리모 조직의 조직학적 특성과 동질성을 확보하여 감별기준을 확립함. 장부경락 상관성 확인에서는 위장관 동물모델에서 체표반응점의 침자극 효과가 DRG 내 신경경로를 통하고, 대장-반응점 공통신경의 척수내 경로를 관찰함. 경혈자극의 작용기전 확인에서는 알코올 중독 동물모델에서 경혈 자극이 중독관련부위에서 opioid, sigma 수용체, 교세포 등과 관련되고, 코카인 중독 동물모델에서 코카인 중독행동 억제가 척수 배주신경로와 관련됨을 확인함. 또한, 불면증 동물모델에서 경혈자극의 신경세포 활성화와 우울증 동물모델에서 경혈자극의 치료기전에 해마의 BDNF와 NPY가 관련됨을 확인함. 임상시험을 통한 작용기전 확인에서는 fMRI를 이용하여 전기 자극 후 통증 처리 뇌영역 활성화를 관찰하고, EEG를 측정하여 경혈과 비경혈의 반응 차이 및 경혈자극의 감각·자율신경계 반응과 호흡에 따른 역치변화를 확인함

( 출처 : 보고서 초록 5p )

Abstract ▼

Ⅳ. Results
○ Investigations on the morphological characteristics of acupuncture points and the connectivity between internal organ and meridian system (2013–2017)
2013
- Establishment of a gastrointestinal animal model for the study of connectivity between internal organ and meridian system

Ⅳ. Results
○ Investigations on the morphological characteristics of acupuncture points and the connectivity between internal organ and meridian system (2013–2017)
2013
- Establishment of a gastrointestinal animal model for the study of connectivity between internal organ and meridian system
- identification of histological characteristics and homogeneity in primo tissues distributed in the falciform ligament
- identification of histological homogeneity in primo tissues collected from different location
2014
- identification of surface reaction points and acupuncture stimulation effects in a colitis animal model
- identification of histological homogeneity in primo tissues collected from different species
2015
- identification of neural pathways in DRG from the colon and reaction points using a neuro-tracing technique
- Establishment of differential criteria for primo tissues using histological characteristics
2016
- Observations on the spinal ascending pathways of colon-reaction point common nerves using a neurotracer
2017
- Setup of extra cellular recording experiment facilities and colitis pain signals
- identification of reduced colitis pain signals through acupuncture stimulation

○ Neurological signaling pathway of stimulation on the acupuncture points (2013–2017)
2013
- Preparation of an alcoholism model using a two-bottle choice method
- Identification of treatment effects by stimulation using the mechanical acupuncture instrument
2014
- Establishment of a voluntary alcoholism animal model and identification of alcohol intake reduction effect by acupuncture treatment
- Investigation on the involvement of spinal dorsal neural pathway in the acupuncture treatment for cocaine behavior suppression
2015
- Evaluation of the connection between voluntary alcoholism and opioids
- Evaluation of the connection between voluntary alcoholism and sigma receptors
2016
- identification of the interrelationship between acupuncture treatment and sigma receptors in alcoholic animals
- Roles of glia cells in a voluntary alcoholism model
2017
- identification of the relationship between acupuncture treatment and glutamatergic nerves in alcoholic animals
- identification of the relationship between acupuncture stimulation and habenula, a new area related to addiction

○ Bio-imaging studies on the effect of stimulation on the acupuncture points to the brain(2013-2017)
2013
- Identification of improved cognitive functions by acupuncture treatment on KI6 and Bl62 through ERP measurements
- Observations on the activation of brain areas related to pain control after electrical stimulation through fMRI
2014
- Identification of the differences in the sensory threshold in the acupuncture points and non-acupuncture points through 64-channel EEG instrument and SEP measurements
- Development of analytical tools for comparing the interrelationship among brain areas and observations of brain activation differences in control groups and patient groups through electro-acupuncture stimulation
2015
- identification of differences in the reaction of sensory nervous system and autonomic nervous system by stimulation on the acupuncture points, stimulation on the non-acupuncture points, and false stimulation through SEP measurements
- Development of analytical tools for the bicoherence visualization and time series data similarities
2016
- identification of threshold changes of acupuncture stimulation sensory recognition by respiration using SEP measurements
- Setup of clinical study design and experimental equipment for confirming the brain wave reactions of 4 meridian systems by acupuncture stimulation
- Design and materialization of the platform system for the development of time series data analysis tools, loading of user-interface design and existing analytical tools
2017
- identification of the meridian system theory through brain wave reactions and bio-electrical changes of 4 meridian systems by source point acupuncture stimulation
- Development of time series data analysis tools: loading the additional analytical module and ensuring compatibility/expandability, verification through actual experimental data and error correction

○ Studies on the acupuncture treatment mechanism in emotional and cognitive disorders (2015–2017)
2015
- Identification of reduced sleeping time and slow-wave sleep due to serotonin deficiency in an animal model with PCPA-induced insomnia
- Identification of reduced sleeping time and slow-wave sleep in an animal model with ovariectomy-induced insomnia
- Identification of reduced voluntary movement in an open field and reduced sucrose intake in an animal model with extreme stress-induced depression
2016
- Investigation on the efficacy of the acupuncture treatment (HT7) through EEG measurements in an animal model with cage exchange-induced insomnia
- Investigation on the efficacy of the acupuncture treatment (HT7) through EEG measurements in an animal model with caffeine-induced insomnia
- Investigation on the efficacy of the acupuncture treatment (PC6) through stress-index behavior experiments in an animal model with repeated restraint stress-induced depression
- Investigation on the efficacy of the acupuncture treatment (SP6) through stress-index behavior experiments in an animal model with ovariectomy-induced depression
2017
- Investigation on the c-fos activation in the nucleus accumbens through stimulation on the acupuncture points as an efficacy mechanism in an animal model with caffeine-induced insomnia
- Investigation on the relationship between BDNF and NPY in the hippocampus through stimulation on the acupuncture points as an efficacy mechanism in an animal model with climacterium-like depression

( 출처 : SUMMARY 11p )

목차 Contents

• 표지 ... 1
• 제 출 문 ... 3
• 보고서 초록 ... 5
• 요 약 문 ... 7
• SUMMARY ... 10
• CONTENTS ... 14
• 목차 ... 15
• 1장. 경혈의 형태학적 특성 및 경락장부 상관성 규명 (2013–2017) ... 17
• 1. 경혈의 형태학적특성 규명 ... 17
• 2. 체표 특이점과 경락장부 상관성 규명 ... 20
• 2장. 경혈자극의 신경학적 신호전달체계 규명 (2013–2017) ... 33
• 1. 알코올 중독 동물모델에서 경혈자극 신경계 작용기전 규명 ... 33
• 2. 코카인 중독 동물모델에서 경혈자극의 신경계 작용기전 규명 ... 46
• 3. 통증동물모델에서 경혈 자극의 신경계 작용기전 규명 ... 48
• 3장. 경혈자극 효과의 Bio imaging 연구 (2013-2017) ... 53
• 1. 경혈자극의 뇌기능 변화 확인 ... 53
• 2. 경혈자극 특성 확인 ... 58
• 3. 경락 상관성 확인 ... 68
• 4. 시계열 data 분석 도구 개발 ... 71
• 5. fMRI 측정을 통한 만성요통환자의 경혈자극 효과 확인 ... 74
• 6. 정서유발 인체감각 반응지도 및 정신생리학적 작용기전 확인 ... 81
• 4장. 정서 및 인지장애에 대한 침구치료 작용기전 연구 (2015–2017) ... 90
• 1. 불면증 모델에서 경혈자극의 효과기전 규명 ... 90
• 2. 우울증 모델에서 경혈자극의 효과기전 규명 ... 95
• 참 고 문 헌 ... 108
• 참 고 자 료 ... 115
• 끝페이지 ... 122