초록 ▼

본 연구는 기능성 골충전재와 차폐막의 개발에 대한 연구로서,골충전재의 경우 뷰티레이트가 함유된 골충전재를 개발하고, 이의 안전성 및 성능을 평가하였음. 재생저하환자에 대한 유효성을 검증하기 위해 재생저하 동물모델을 개발하여 골충전재를 적용한 결과, 개발한 골 충전재의 효과가 입증되었으며, 식약처 임상시험승인을 위한 생물학적 안전성 시험에서 안전성을 확보하였음.
또한 연조직과 경조직의 동시재생을 위한 다기능성 차폐막은 재생이 저하된 골 결손부에 적용한 결과 증진된 조직재생 결과를 획득하였음

( 출처: 보고서 요약서

본 연구는 기능성 골충전재와 차폐막의 개발에 대한 연구로서,골충전재의 경우 뷰티레이트가 함유된 골충전재를 개발하고, 이의 안전성 및 성능을 평가하였음. 재생저하환자에 대한 유효성을 검증하기 위해 재생저하 동물모델을 개발하여 골충전재를 적용한 결과, 개발한 골 충전재의 효과가 입증되었으며, 식약처 임상시험승인을 위한 생물학적 안전성 시험에서 안전성을 확보하였음.
또한 연조직과 경조직의 동시재생을 위한 다기능성 차폐막은 재생이 저하된 골 결손부에 적용한 결과 증진된 조직재생 결과를 획득하였음

( 출처: 보고서 요약서 3p )

Abstract ▼

□ Purpose&Contents
< Research Purpose >
* The aim of this research was to develop multi-functional bone filling material which is applicable to regeneration reducing disorder such as osteomyelitis of jaw and membrane capable of regenerating oral soft and hard tissue simultaneously.

< Re

□ Purpose&Contents
< Research Purpose >
* The aim of this research was to develop multi-functional bone filling material which is applicable to regeneration reducing disorder such as osteomyelitis of jaw and membrane capable of regenerating oral soft and hard tissue simultaneously.

< Research Contents >
* Development of bone filling material for regeneration reducing disorder: Bone filling material containing low-molecular-weight drugs (HDIs, PHIs) for osteogenesis stimulation was produced, and safety and efficacy was assessed for clinical trial. Also developed animal model for the verification of efficacy.
* Development of fused membrane for regeneration reducing disorder: For the development of multi-functional membrane simultaneously regenerating soft and hard tissue, suitable bio-active substance was investigated, and produced membrane consist of neutral PLGA which has been biocompatible improved. The membrane has been assessed for safety and efficacy.

□ Results
* Development of functional bone filling material for regeneration reducing disorder
- Verified the effect of low-molecular-weight compound on osteogenesis stimulation(dimethyloxalylglycine and butyrate), and developed a bone filling material containing the osteogensis stimulating material (domestic patent registered). Pre-clinical safety experiment on the bone filling material containing butyrate has been done, and a proposal for clinical trial approval has been submitted.
- Establishment of regeneration reducing animal model and application of the functional bone filling material: to assess the efficacy of the functional bone filling material, jawbone osteoradionecrosis model, bisphosphonate osteonecrosis of jaw model, bacterial infected osteomyelitis of jaw model and diabetes regeneration reducing disorder model have been established, and these were used to verify the effect of functional bone filling material.
* Development of fused membrane for regeneration reducing disorder
- To minimize the local inflammatory reaction from degradation of PLGA membrane, porous PLGA scaffold was produced by adding neutralization-inducing polymer.
- For the development of multi-functional membrane based on the porous PLGA scaffold, triple layered membrane was produced and efficacy of the soft and hard tissue regeneration on an animal model was observed (domestic patent registered).
- Developed and produced membrane based on variety collagen scaffold (permission of articles acquired).
- Anti-bacterial PLGA membrane was produce by marco/nano-capsule containing anti-bacterial substance.

□ Expected Contribution
- Increase in treatment effect is expected for the patients with the systemic disease with blood supply disability and various inflammatory bone tissue damage, by applying the bone filling material developed from this research.
- Various bone tissue reducing models have been developed which are expected to be used for developing different bone filling materials in the future.
- Patent registered multi-functional membrane is expected to increase the treatment effect for the patient with periodontal disease who has reduced regeneration ability.

( 출처: SUMMARY 5p )

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• Contents ... 6
• 목차 ... 7
• 1. 연구개발과제의 개요 ... 8
• 1-1. 연구개발 목적 ... 8
• 1-2. 연구개발의 필요성 ... 8
• 1-3. 연구개발 범위 ... 8
• 2. 국내외 기술개발 현황 ... 9
• 3. 연구수행 내용 및 결과 ... 14
• 4. 목표달성도 및 관련분야 기여도 ... 175
• 4-1. 목표달성도 ... 175
• 4-2. 관련분야 기여도 ... 176
• 5. 연구결과의 활용계획 ... 177
• 6. 연구과정에서 수집한 해외과학기술정보 ... 179
• 7. 연구개발성과의 보안등급 ... 179
• 8. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 179
• 9. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 179
• 10. 연구개발과제의 대표적 연구실적 ... 180
• 11. 기타사항 ... 180
• 12. 참고문헌 ... 181
• [별첨4] 실적 증빙자료 ... 183
• [별첨5] 기타 첨부서류 ... 252
• 끝페이지 ... 268