초록

연구목적: 알츠하이머병의 새로운 치료타켓 발굴 및 치료법 개발
-알츠하이머 환자 및 동물모델에서 비정상적인 스핑고지질 대사 발견
-알츠하이머 뇌혈관내피세포에 초점을 둔 치료법의 가능성을 확립함
-알츠하이머 뇌혈관내피세포에서 스핑고지질 대사조절을 위한 다양한 치료법을 확립함

(출처 : 보고서 요약서 3p)

Abstract ▼

□ Purpose& Contents
Abnormal vascular endothelial growth factor (VEGF) and sphingolipid metabolism has been previously reported in Alzheimer’s disease (AD). This study is focused on the regulatory effects of blood-brain barrier by VEGF and sphingolipid
[First year]: The changes of brain endoth

□ Purpose& Contents
Abnormal vascular endothelial growth factor (VEGF) and sphingolipid metabolism has been previously reported in Alzheimer’s disease (AD). This study is focused on the regulatory effects of blood-brain barrier by VEGF and sphingolipid
[First year]: The changes of brain endothelial cells by VEGF & sphingolipid in Alzheimer's disease
[Second Year]: Investigation of regulatory mechanism in brain endothelial cells by VEGF & sphingolipid
[Third Year]: Examination of the therapeutic possibility by sphingolipid regulating factors in patient's-derived cells

□ Results
- Abnormal sphingolipid metabolism was found in blood and brain samples derived from AD patient
- Brain endothelial cells were damaged in AD animal models, but regulation of sphingolipid protected the endothelial cell dysfunction
- Neuronal dysfunction in AD mice was diminished in sphingolipid regulated AD mice.
- Endothelial cell specific sphingolipid increase induced BBB dysfunction and neuronal abnormality
- Normalization of sphingolipid in blood of AD mice ameliorated AD pathology, such as Abeta deposition, neural cell dysfunction, BBB damage and behavioral impairment.
- Abnormal sphingolipid metabolism in brain endothelial cells showed increase of ccaveolae-mediated transcytosis, which was related to Actin formation.

□ Expected Contribution
- By finding a new therapeutic targets such as brain endothelial cells, our results will provide a novel therapeutics for neurological diseases such as AD
- By investigating the abnormal sphingolipid metabolism in AD, our data will be able to guide a new treatment that can be clinically applied, not just for theoretical research

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제 출 문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• 영문목차 ... 6
• 목차 ... 6
• 1. 연구개발과제의 개요 ... 7
• 2. 국내외 기술개발 현황 ... 7
• 3. 연구수행 내용 및 결과 ... 9
• 4. 목표달성도 및 관련분야 기여도 ... 24
• 5. 연구결과의 활용계획 ... 25
• 6. 연구과정에서 수집한 해외과학기술정보 ... 26
• 7. 연구개발성과의 보안등급 ... 26
• 8. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 26
• 9. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 27
• 10. 연구개발과제의 대표적 연구실적 ... 27
• 11. 기타사항 ... 27
• 12. 참고문헌 ... 28
• [별첨4] 실적 증빙자료 ... 29
• [별첨5] 기타 첨부서류 ... 32
• 끝페이지 ... 36