초록

성호르몬의 영양대사 조절에 대한 분자 유전학적 연구를 수행함.
영양 상태를 매개하는 신호전달 체계와 성호르몬 작용체계와의 상호 작용 기전 분석하였고 이를 통해 성호르몬 작용기전 제어를 통한 새로운 계열의 대사 증후군 치료법 개발에 기초를 제공

(출처 : 요약서 3p)

Abstract ▼

Purpose&Contents
- Molecular genetic studies about the regulation of nutritional metabolism by sex hormones
- Analysis of the interaction between nutritional status mediated signaling and sex hormone signaling pathways
- Study of the relationship between aging-related physiological decline

Purpose&Contents
- Molecular genetic studies about the regulation of nutritional metabolism by sex hormones
- Analysis of the interaction between nutritional status mediated signaling and sex hormone signaling pathways
- Study of the relationship between aging-related physiological decline and nutritional metabolism mediated by sex hormone signaling

Results
Identification of signal communication between biological energy sensing machinery and other metabolic organ
- Identifying the humoral factors regulated by the ecdysone-miR-8 pathway in the fruit fly fat body and verifying their function in the organismal growth

Mutational analysis of Drosophila melanogaster metabolism homeostasis control by key genes functioning in the network between nutrient energy metabolism signal and ecdysone signal
- Establishment of transgenic Drosophila animal model of Torso gene expressed in prothoracic gland, a fruit fly steroid hormone producing organ
- Study on the organismal growth and Insulin / TOR Signal Regulation meidated by Torso by using Torso transgenic animal model

Analysis of nutritional metabolism at the level of transcription and post-transcription by ecdysone signaling
- Identification of genes and signaling pathways associated with ecdysone signaling
- Analysis of the influence of drugs on sex hormone-related physiological changes that are assoicated with identifed signalnig pathway

Analysis of aging effect through the verification of lifespan, stress resistance, and ROS generation by key gene mutations mediating the interaction between the ecdysone signal and the nutrient energy signal

- Identifying that the drug affecting the nutritional metabolism-ecdysone network signaling system acts on FOXO, a key gene mediating the ecdysone signal and nutrient energy signal, to increase the lifespan and ROS stress resistance of Drosophila

Expected Contribution
The result of our study will deepen our understanding of the physiological functions of sex hormones by accumulating new knowledge that has not yet been clarified in domestic as well as overseas academic circles. In addition, this study will be useful in developing candidate substances for the treatment of metabolic syndrome through control of sex hormone action mechanism. This will enable the development of new biopharmaceuticals

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제출문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• 목차 ... 6
• 1. 연구개발과제의 개요 ... 7
• 1-1. 연구개발 목적 ... 7
• 1-2. 연구개발의 필요성 ... 7
• 1-3. 연구개발 범위 ... 10
• 2. 국내외 기술개발 현황 ... 10
• 3. 연구수행 내용 및 결과 ... 13
• 4. 목표달성도 및 관련분야 기여도 ... 34
• 5. 연구결과의 활용계획 ... 36
• 6. 연구과정에서 수집한 해외과학기술정보 ... 37
• 7. 연구개발성과의 보안등급 ... 37
• 8. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 37
• 9. 연구개발과제 수행에 따른 연구실 등의 안전조치 이행실적 ... 37
• 10. 연구개발과제의 대표적 연구실적 ... 37
• 별첨: 실적 증빙자료 ... 40
• 별첨: 기타 첨부서류 ... 51
• 끝페이지 ... 58