Abstract ▼

□ Purpose&Contents
< Final objectives >
Discovery of target molecules relevant to osteosarcoma metastasis and evaluation of their usefulness as a biomarker

< Detailed objectives >
1) Discovery of target molecules relevant to osteosarcoma metastasis, and development of measures to blo

□ Purpose&Contents
< Final objectives >
Discovery of target molecules relevant to osteosarcoma metastasis and evaluation of their usefulness as a biomarker

< Detailed objectives >
1) Discovery of target molecules relevant to osteosarcoma metastasis, and development of measures to block or suppress metastasis/progression of osteosarcoma using these targets
2) Discovery of useful biomarkers selected from these target molecules

< Study contents >
￭ Role of ICSBP for the Induction of TGF-βRI and growth promotion of osteosarcoma cells
￭ Transcriptional activation of RI by ICSBP
￭ Discovery of molecules regulating PD-L1 and survivin expression in osteosarcoma cells and elucidation of their signal pathway
￭ Stimulatory effect of PD-L1 on the growth and ELP in osteosarcoma cells
￭ Discovery of candidate biomarkers for osteosarcoma

□ Results
< quantitative results >
• We published two SCI-registered papers with impact factor of ≥ 4 (100% attainment as compared with initial goal)
• Two times of presentation in domestic or international conferences (100% attainment as compared with initial goal)

< qualitative results >
• Elucidation of mechanism underlying the induction of RI by ICSBP
• Demonstration of positive feedback effect of EGFR and PD-L1 on the induction of each other
• Demonstration of promoting effect of PD-L1 on the growth and ELP of osteosarcoma cells

□ Expected Contribution
• Combination therapy using regulatory molecules of PD-L1 and anti-PD-L1 antibody may be a new armamentarium for survival gain of recurrent/refractory osteosarcoma.
• Combination therapy using doxorubicin, an osteosarcoma chemotherapeutic agent, and PD-L1 blockade may be utilized in clinical practice.
• Combination of EGFR inhibitor and PD-L1 blockade may enhance antitumor effect.
• Current study opened the way for the development of osteosarcoma biomarker panel using survivin and TNF-α.

(출처 : SUMMARY 3p)

목차 Contents

• 표지 ... 1
• 국문 요약문 ... 2
• SUMMARY ... 3
• 목차 ... 4
• 1. 연구개발과제의 개요 ... 5
• 1-1. 연구개발의 필요성 ... 5
• 1-2. 연구개발의 최종 목적 ... 5
• 1-3. 연구가설 ... 6
• 2. 연구수행 내용 및 결과 ... 6
• 2-1. 연구내용, 연구수행방법, 연구결과 ... 6
• 3. 연구결과의 중요성 및 활용 방안 ... 14
• 3.1 연구결과의 중요성 ... 14
• 3.2 연구결과의 활용 방안 ... 14
• 4. 연구수행 달성도 ... 15
• 5. 연구개발과제의 대표적 연구실적 ... 15
• 6. 참여연구원 현황 ... 16
• 7. 기타사항 ... 16
• 8. 참고문헌 ... 16
• 끝페이지 ... 17