초록

○ BaSO₄와 생분해성 polymer를 결합, 의료영상에서 식별성이 우수하며, 입자선 치료시 선량오류가 최소화되는 바이오 표지자 개발과 표지자를 생체내에 투입하는시스템개발.
○ X-선 영상과 비 X-선 영상을 결합한 실시간 타겟 모니터링 시스템 개발 완료,
○ 암표적 유전자 전달체와 방사선 병용 치료 효과 검증을 위한 in vivo 동물 종양 모델 개발 및 암표적 유전자 전달체에 의한 방사선 치료 증진 효과를 위한 in vivo에서 확인.

(출처 : 보고서 요약서 3p)

Abstract ▼

Purpose & Contents
Purpose:
To develop a charged particle treatment technique which can monitor the tumor position in real time using digital medical imaging and control the radiation synchronized with the tumor position. In order to improve the quality of treatments, biodegradable radiopaque

Purpose & Contents
Purpose:
To develop a charged particle treatment technique which can monitor the tumor position in real time using digital medical imaging and control the radiation synchronized with the tumor position. In order to improve the quality of treatments, biodegradable radiopaque fiducial marker will be developed.
Contents:
1st stage (2012 ~2014) : Development of real-time tumor monitoring technique with biodegradable radiopaque markers.
○ Biodegradable radiopaque marker
Develope a material by combining radiopaque material such as BaSO₄ and polymer which has characteristics of high contrast in X-ray images and absorbed in tissues about 12 weeks after injection. The marker delivery system will be developed.
○ Target tumor monitoring system.
Using various medical imaging modalities, a technique which detects the position of the target tumor and computes the 3-dimensional position will be developed. To reduce the radiation dose to patients, radiation and non-radiation medical images will be combined.
2nd stage (2015 ~ 2016) : Development of cancer target gene carriers monitoring technique and gene-radiation combination therapy.
○ Pellet type radiopaque marker
Develope a pellet type fiducial marker have excellent formability and biological stability. It show excellent discrimination in vivo X-ray image.
○ Development of pellet type marker delivery system
Development of the in vivo delivery device equipped with the pellet type bio marker and evaluation of in vivo test.
○ Target tracking particle radiation
A scanning technique controls the particle radiation synchronized with the target position in real time will be developed.
○ The characteristics of cancer target gene carriers for a radiation marker will be studied.
A gene-radiation combined therapy will be investigated.

Results
○ Develope a bio fiducial marker by combining BaSO₄ and biodegradable polymer.
○ Developed fiducial marker has good detectability in X-ray imaging and reduces the dose perturbation in use of particle therapy. Also fiducial marker delivery system was successfully developed.
○ Real-time target monitering system was developed with combining X-ray imaging system and camera system. The accuracy of the developed system was validated.
○ Evaluation of a combinational anticancer effect of cancer-trageted gene therapy and radiotherapy in tumor xenograft models

Expected Contribution
○ Acquiring patents on biodegradable marker, preempt in an emerging market is expected.
○ With development on a state-of-the-art technique, relevant technologies such as medical imaging technology, system control technology and radiation treatment planning are improved.
○ Tumor tracking particle therapy will improve the treatment outcome and quality of life of cancer patients.
○ By enhance the cancer cure rate with reducing complication, overall medical expenses in our society will be reduced.

(출처 : SUMMARY 5p)

목차 Contents

• 표지 ... 1
• 제출문 ... 2
• 보고서 요약서 ... 3
• 국문 요약문 ... 4
• SUMMARY ... 5
• CONTENTS ... 6
• 목차 ... 7
• 제1장. 연구개발과제의 개요 ... 8
• 제2장. 국내외 기술 개발 현황 ... 11
• 제3장. 연구 수행 내용 및 성과 ... 12
• 3-1. 2012년도 연구 수행 내용 및 성과 ... 12
• 3-2. 2013년도 연구 수행 내용 및 성과 ... 24
• 3-3. 2014년도 연구 수행 내용 및 성과 ... 41
• 3-4. 2015년도 연구 수행 내용 및 성과 ... 50
• 3-5. 2016년도 연구 수행 내용 및 성과 ... 69
• 제4장. 목표 달성도 및 관련 분야 기여도 ... 91
• 제5장. 연구개발성과의 활용계획 ... 107
• 제6장. 연구 과정에서 수집한 해외 과학기술 정보 ... 109
• 제7장. 연구개발성과의 보안등급 ... 110
• 제8장. 국가과학기술종합정보시스템에 등록한 연구시설·장비 현황 ... 111
• 제9장. 연구개발과제 수행에 따른 연구실 등의 안전 조치 이행 실적 ... 112
• 제10장. 연구개발과제의 대표적 연구 실적 ... 113
• 제11장. 기타 사항 ... 114
• 제12장. 참고 문헌 ... 115
• 끝페이지 ... 117