보고서 정보
주관연구기관 |
경기도경제과학진흥원 |
연구책임자 |
최춘환
|
참여연구자 |
홍성수
,
정원식
,
이미기
,
최윤혁
,
권혁진
,
이지은
,
정연우
,
조영락
,
이재연
|
보고서유형 | 최종보고서 |
발행국가 | 대한민국 |
언어 |
한국어
|
발행년월 | 2021-02 |
과제시작연도 |
2020 |
주관부처 |
농촌진흥청 Rural Development Administration(RDA) |
등록번호 |
TRKO202100009714 |
과제고유번호 |
1395062910 |
사업명 |
차세대바이오그린21(R&D) |
DB 구축일자 |
2021-09-18
|
키워드 |
여뀌속.기능성 화장품.표준화.분석법검증.유효성분.Persicaia.Cosmeceutical.Standardization.Validation.Active compound.
|
초록
▼
여뀌속 식물을 이용한 기능성 향장소재를 개발하기 위해 50여개의 여뀌속 추출물을 이용 생리활성 검증후 우수소재 4종 발굴(사광이아재비, 사광이풀, 흰꽃여뀌, 이삭여뀌), 40개체 여뀌속 nrDNA ITS 기반 유전자 분석을 통한 유전자 판별기술개발. 우수 기능성 소재들의 성분연구를 통한 15개의 화합물을 분리정제 및 구조결정완료. 생리활성 평가를 통한 항산화 12종, 염증 6종, 미백 3종 주름개선 2종의 화합물 기능성 검증, 기능성 소재 3종(사광이아재비, 흰꽃여뀌, 이삭여뀌) ICID 등재 완료. 기능성소재 2종에 대한 안전성
여뀌속 식물을 이용한 기능성 향장소재를 개발하기 위해 50여개의 여뀌속 추출물을 이용 생리활성 검증후 우수소재 4종 발굴(사광이아재비, 사광이풀, 흰꽃여뀌, 이삭여뀌), 40개체 여뀌속 nrDNA ITS 기반 유전자 분석을 통한 유전자 판별기술개발. 우수 기능성 소재들의 성분연구를 통한 15개의 화합물을 분리정제 및 구조결정완료. 생리활성 평가를 통한 항산화 12종, 염증 6종, 미백 3종 주름개선 2종의 화합물 기능성 검증, 기능성 소재 3종(사광이아재비, 흰꽃여뀌, 이삭여뀌) ICID 등재 완료. 기능성소재 2종에 대한 안전성 테스트 완료, 기능성 소재를 함유하는 시제품 생산 2건 완료, 임상시험을 통한 기능성 검증 완료(미백2건, 주름개선 1건). HPLC를 이용한 유효물질 분석법 개발 완료. 우수 연구성과 지식재산권 확보(특허 출원 4건, 등록 3건, 학술발표 2건, 논문 2건(1건 출판, 1건 게재승인). 기술이전 완료 (1건), 언론홍보(21건)
(출처 : 요약서 3p)
Abstract
▼
□ Purpose&Contents
○ Development of functional cosmetic materials from persicaria plants
- Discovering excellent functional cosmetic materials from plants
- Separation and fining and structure determination of indicators and effective substances of discovered cosmetic materials
- Validat
□ Purpose&Contents
○ Development of functional cosmetic materials from persicaria plants
- Discovering excellent functional cosmetic materials from plants
- Separation and fining and structure determination of indicators and effective substances of discovered cosmetic materials
- Validation of effective ingredients
- Establishment of analysis method to standardize raw materials for functional cosmetics
- Registered ICID, a plant of the persicaria genus.
- Prototype production and clinical trial CRO implementation
- Technology transfer of excellent cosmetic materials discovered from the persicaria genus
□ Results
○ Completion of gene analysis based on nrDNA ITS (base sequence analysis, Bayesian inference analysis, UPGMA collection analysis)
○ Discover 3 excellent materials through verification of physiological activity using 50 kinds of plant extracts of the persicaria genus.
○ Structural analysis by separating 15 kinds of compounds through component research of excellent functional materials
○ Functional verification of compounds of 12 antioxidants, 6 types of inflammation, 3 types of whitening, and 2 types of wrinkle improvement by verifying the physiological activity of the separated ingredients
○ Completion of compound analysis method development through HPLC profiling of compounds separated from functional material ingredient research
○ Completion of development of indicator and effective substance analysis method using HPLC
○ Completed ICID registration for 3 types of functional materials
○ Completed safety test for two functional materials
○ Completed production of 2 prototypes containing functional materials, and verified functionality through clinical trials (2 whitening, 1 wrinkle improvement)
○ Completed the development of an effective substance analysis method using HPLC
○ Completion of technology transfer of company using excellent functional materials
○ Securing excellent research results and intellectual property rights (4 patent applications, 3 registrations, 2 academic presentations, 1 paper (1 case approved for publication))
○ Media promotion (promotion of outstanding research results from 21 media companies)
○ Functional material plant specimen production completed
□ Expected Contribution
○ Scientific aspect
- If it receives individual recognition as a good functional ingredient for < Functional Cosmetics > from the Ministry of Food and Drug Safety, it is planned to be used for development as a variety of cosmetic formulations as well as sales as functional ingredients.
- Unlike cosmetic materials so far, the material to be developed through this study is a material that has secured stability with minimal side effects, and will be used as basic data for the development of high-performance materials using active components in the future.
○ Technical aspect
- The result of this study is meaningful that it has been made into a high value-added material by using a material that has not been used as a cosmetic material.
- In the previous study, the genus persicaria plants have a superior effect than the existing functional ingredients, so through this study, it is expected that the development of individually recognized functional cosmetic ingredients with less side effects and excellent efficacy is expected.
- If a cosmetic material is developed using domestic natural resources of the persicaria genus, it is expected to develop a high-performance cosmetic material with less side effects even for long-term use.
- Preemptively preemptive and secure patents for functional cosmetic materials showing the effect of improving cosmetic functions
- It is expected that cosmetic materials with proven functionality will be used in the development of various cosmetic products, creating high added value as cosmetic materials.
○ Economic and industrial aspects
- After the Convention on Biological Diversity, huge losses are expected in the domestic bio industry, especially cosmetics companies using overseas biological materials. However, it is expected that the economic added value will be great if functional cosmetic materials are developed using native plants of the persicaria genus.
- It is expected that it will contribute to increase the income of cultivated farmers through the high value-added of domestic agricultural and forestry resources and will greatly help in revitalizing the rural economy.
- It is expected to contribute to the creation of new businesses, revitalization of the cosmetics industry at home and abroad, and job creation through the development of new products using cosmetic materials originating from natural products (food registered medicinal crops).
○ Job creation and cultivation aspect
- When new individually recognized functional ingredients are developed and commercialized as functional cosmetics, it is expected to contribute greatly to the revitalization of the domestic functional cosmetics industry as well as job creation by revitalization of related industries (cosmetic manufacturers, distribution companies, etc.).
- It is expected to contribute to the cultivation of excellent professionals who can do convergent thinking and research through industrial and industrial research.
(출처 : SUMMARY 5p)
목차 Contents
- 표지 ... 1
- 제 출 문 ... 2
- 보고서 요약서 ... 3
- 국 문 요 약 문 ... 4
- Summary ... 5
- 목차 ... 9
- 제 1 장 연구 개발 과제의 개요 ... 10
- 제1절 연구 개발 목적 ... 10
- 제2절 연구 개발의 필요성 ... 10
- 제3절 연구 개발 범위 ... 24
- 제 2 장 연구 수행 내용 및 결과 ... 26
- 제 3 장 목표달성도 및 관련분야 기여도 ... 131
- 제1절 목표대비 달성도 ... 131
- 제2절 정량적 성과(논문게재, 특허출원, 기타)를 기술 ... 132
- 제 4 장 연구 결과의 활용 계획 ... 132
- 제 5 장 연구 개발 결과의 보안 등급 ... 133
- 제 6 장 연구시설·장비종합정보시스템에 등록한 연구시설·장비 현황 ... 133
- 제 7 장 연구개발과제의 대표적 연구실적 ... 133
- 제 8 장 기타사항 ... 133
- 제 9 장 참고문헌 ... 134
- 끝페이지 ... 138
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